depigmentation

Monobenzone (Benoquin) is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by means of Depigmenting Activity.

Mequinol (Leucobasal) is a synthetic derivate of hydroquinone and depigmenting agent. Although the exact mechanism of the depigmenting effects of mequinol remains unclear, it may exert its effect by oxidation of tyrosinase to cytotoxic products in melanocytes.

N-Ac-4-S-CAP is a compound that exhibits selective cytotoxicity towards melanin-producing cells in mouse hair follicles, causing 98% depigmentation. Within four hours of intraperitoneal injection, visible changes occur in these melanocytes, including the aggregation of melanin granules and nuclear condensation. Electron microscopy reveals progressive destruction of these cells, evidenced by swelling of membranous organelles, nuclear condensation, and cytoplasmic vacuolization, leading ultimately to complete cell death. N-Ac-4-S-CAP selectively targets active melanin-producing melanocytes but does not appear to affect precursor or dormant melanocytes. These properties suggest potential applications for N-Ac-4-S-CAP in melanoma suppression or skin whitening.

Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important foodborne pathogens. It (100 ug disc) displays potential anticandidal effect against Candia albica