d18:0

N,N-dimethyl Sphinganine (d18:0) is a sphingolipid that increases during development ofL. donovanipromastigotes.1 1.Silva, A.M., Cordeiro-da-Silva, A., and Coombs, G.H.Metabolic variation during development in culture of Leishmania donovani promastigotesPLoS Negl. Trop. Dis.5(12)e1451(2011)

C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. [2] It is also elevated in the skin of patients with lesional atopic dermatitis.[3]

C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squamous carcinoma cells in vitro.[4] C24 dihydro Ceramide levels are also increased in INS-1 β-cells incubated with glucose and palmitate.[5]

D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0) . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. D-threo Sphinganine (d18:0) is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver.

C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0) is a lipid molecule that can be used in life science related research. The CAS number of C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0) is 164989-36-0.

"(±)-2'-Hydroxy Ceramide (d18:0/18:0) is a sphingomyelin derivative isolated from mammalian platelets upon ADP stimulation [1]."

C16((±)-2'-hydroxy) dihydro Ceramide (d18:0/16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16((±)-2'-hydroxy) dihydro Ceramide (d18:0/16:0) is 190249-36-6.

C6 dihydro Ceramide (d18:0/6:0) is a lipid molecule that can be used in life science related research. The CAS number of C6 dihydro Ceramide (d18:0/6:0) is 171039-13-7.

C12((±)-2'-hydroxy) dihydro Ceramide (d18:0/12:0) is a lipid molecule that can be used in life science related research. The CAS number of C12((±)-2'-hydroxy) dihydro Ceramide (d18:0/12:0) is 2377379-54-7.

C17 dihydro Ceramide (d18:0/17:0) is a lipid molecule that can be used in life science related research. The CAS number of C17 dihydro Ceramide (d18:0/17:0) is 1388156-40-8.

C18 dihydro Ceramide (d18:0/18:0) (Standard) is a reference standard for research and analysis in studies involving C18 dihydro Ceramide (d18:0/18:0). C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond.

C24 dihydro Ceramide (d18:0/24:0) (Standard) is a reference standard for research and analysis in studies involving C24 dihydro Ceramide (d18:0/24:0). C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin. It is found in higher concentrations in female sebum compared to male sebum.

C14 dihydroceramide (d18:0/14:0) (Standard) is a reference standard of C14 dihydroceramide (d18:0/14:0) intended for quantitative analysis, quality control, and related biochemical research applications.

C24 Dihydroceramide(D18:0/24:0)/N-(Tetracosanoyl)-Sphinganine Isotope (Standard) is a reference standard of C24 Dihydroceramide(D18:0/24:0)/N-(Tetracosanoyl)-Sphinganine Isotope intended for quantitative analysis, quality control, and related biochemical research applications.

14:0 Dihydro SM (d18:0/14:0) is a sphingomyelin.

C24 (2'(S)-Hydroxy) dihydro ceramide (d18:0/24:0) is the 2S-isomer of C24 Dihydro ceramide (d18:0/24:0) and serves as the S-isomer of C24 (2'(R)-Hydroxy) dihydro ceramide (d18:0/24:0).

Sphingomyelin (d18:1/12:0) is a polar lipid known for its role in modulating cell signal transduction. It plays a critical role in cell membranes, influencing their fluidity and stability. Additionally, sphingomyelin (d18:1/12:0) is involved in lipid metabolism and has potential in promoting neuronal cell growth. This compound is essential for the functioning and development of the nervous system.

GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a sphingolipid with potential applications in research on Parkinson's disease and Lewy body dementia.

C16 Ganglioside GM1 (d18:1/16:0) (C16-GM1) ammonium, a member of the ganglioside family, features a saturated C16:0 acyl chain. It serves as a functional receptor for the cholera toxin B subunit, although it exhibits lower efficiency in endocytic and retrograde transport pathways. C16 Ganglioside GM1 (d18:1/16:0) ammonium is applicable in diarrhea disease research.

C16 Ceramide (Cer) (d18:1(14Z)/16:0) is a sphingolipid-derived ceramide composed of long-chain sphingoid base (d18:1) and palmitic acid (C16:0). It serves as a crucial lipid signaling molecule for apoptosis. Specifically, C16 ceramide is involved in cell cycle arrest, cell death, and the inhibition of insulin signaling.

C24 Ceramide (d18:1(14Z)/24:0) is a type of ceramide utilized in obesity research.

Cer(d18:2_22:0) is a potential biomarker for metachromatic leukodystrophy.

Lc2Cer(d18:1, 22:0) is a lactosylceramide containing d18:1 and C22:0 ceramide. It is applicable in kidney cortical epithelial cell research.

C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.