curb

URB-694 is a fatty acid amide hydrolase (FAAH) inhibitor.

Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.

Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2 STAT3 with anti-cancer activity.

Hexanorcucurbitacin F is a useful organic compound for research related to life sciences. The catalog number is T123847 and the CAS number is 96253-53-1.

Cucurbitin chloride is a useful organic compound for research related to life sciences. The catalog number is T124186 and the CAS number is 80546-88-9.

Cucurbitacin F is a useful organic compound for research related to life sciences. The catalog number is T124590 and the CAS number is 5939-57-1.

Cucurbitacin R is a useful organic compound for research related to life sciences and the catalog number is T124655.

Cucurbitacin E-2-O-glucoside (2-β-glucopyranoside) is a triterpene compound derived from the roots of Citrullus colocynthis that inhibits pro-inflammatory cytokines.

2,3,16,20,25-Pentahydroxycucurbita-5-ene-11,22-dio is a useful organic compound for research related to life sciences. The catalog number is T126087 and the CAS number is 129393-23-3.

Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications.

1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2 STAT3.

1. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-inflammatory activity through modula

Cucurbitacins from Wilbrandia ebracteata have analgesic effects. Cucurbitacin S has anticancer and antiinflammatory activities.

Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1 CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplas

Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].

Isocucurbitacin D is a compound recognized for its antitumor properties [1].

Hexanorcucurbitacin D, a cucurbitacin, is extractable from the roots of Trichosanthes cucumeroides and is utilized in cardiovascular disease (CVD) research [1].

Dihydroisocucurbitacin B, an active compound, can be extracted from the roots of Wilbrandia ebracteata [1].

23,24-Dihydroisocucurbitacin D (compound 22) is a member of the cucurbitacins [1].

(23E)-5β,19-epoxycucurbita-6,23,25(26)-triene-3β-ol, a cucurbitane triterpenoid, can be isolated from the seeds of Momordica charantia L. [1].

(19R,23E)-5b,19-Epoxy-19-ethoxycucurbita-6,23-diene-3b,25-diol, a cucurbitane-type triterpenoid, exhibited no activity against five cancer cell lines—MCF-7, HepG2, Du145, Colon205, and HL-60—when evaluated using the MTT assay [1].

Cucurbit[7]uril is an emerging candidate for pharmaceutical excipients.Cucurbit[7]uril enhances photosensitization of porphyrins in Neuroblastoma cells

Cucurbitacin D, a triterpenoid isolated from Ecballium elaterium (L.), exhibits anticancer and antitumor activity, inhibits glucose uptake and lactate production in metastatic PrC, and induces inflammasome activation independent of ERK1 2 activation. Cucurbitacin D, a novel inflammasome activator in macrophages, inhibits HepG2 cell proliferation and induces apoptosis by modulating the JAK STAT3, PI3K Akt mTOR and MAPK signaling pathways, and can be used in the study of cervical cancer, leukemia, and prostate cancer.

Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin phospho-myosin II co-aggregates by stimulation of the RhoA ROCK pathway and inhibition of LIM-Kinase.