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cl2a-sn-38 (gmp)

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
CL2A-SN-38 (GMP)
T17731-GMP1279680-68-0
CL2A-SN-38 (GMP) refers to the GMP grade reagents of CL2A-SN-38. CL2A-SN-38 consists of a CL2A linker and an anticancer compound, SN-38, which delivers active molecules within tumor cells and in the tumor microenvironment, often in conjunction with antibodies to make biologically active antibody-coupled reactive molecules (ADCs).
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    CL2A-SN-38
    CL2A-SN38, CL2A SN 38
    T177311279680-68-0
    CL2A-SN-38 consists of a CL2A linker and an anticancer compound, SN-38, which delivers active molecules within tumor cells and in the tumor microenvironment, often in conjunction with antibodies to make biologically active antibody-coupled reactive molecules (ADCs).
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    7-10 days
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    CL2A-SN-38 DCA 1279680-68-0(free base)
    T17731L
    CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .
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