chenodeoxycholic acid

Chenodeoxycholic acid (CDCA) is a bile acid that inhibits 11β-HSD2 with an IC50 value of 22 mM. Chenodeoxycholic acid acts as a detergent to dissolve fat for intestinal absorption and is reabsorbed by the small intestine. Chenodeoxycholic acid is used as a choledocholithiasis, choledocholithiasis and laxative, as well as to prevent or dissolve gallstones.

Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates the nuclear receptor FXR, rescues axonal degeneration of induced pluripotent stem cell-derived neurons in patients with spastic paraplegia type 5 and cerebral xanthomatosis, and can be used to study pancreatic necrosis.

Chenodeoxycholic acid 3-glucuronide (CDCA-3G), a metabolite of Chenodeoxycholic acid (CDCA), is synthesized in human liver microsomes.

Chenodeoxycholic acid 24-acyl-β-D-glucuronide (CDCA-24G), a metabolite of CDCA, is synthesized from CDCA via the action of the UDP-glucuronosyltransferase (UG UT) isoform UGT1A3.

Chenodeoxycholic acid 7-sulfate sodium is a bile acid and a metabolite of Chenodeoxycholic acid.

Chenodeoxycholic acid 3-sulfate, a bile acid, closely corresponds with the extent of hepatic dysfunction [1].

Chenodeoxycholic acid disulfate sodium is a derivative of Chenodeoxycholic acid.

Glycochenodeoxycholic Acid (Lithocholylglycine) is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxycholic acid. Glycolithocholic acid levels are decreased in lean mice treated with obestatin. Serum glycolithocholic acid levels increase with age in children.

Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.

Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties. It can increase glucose-induced insulin secretion and stimulate the electrical activity of α2-cells and enhance cytosolic Ca(2+) concentration ([Ca(2+)](c)).

Chenodeoxycholic acid-d5 is a deuterium-labeled form of Chenodeoxycholic Acid. This hydrophobic primary bile acid can activate the nuclear receptor FXR, which is involved in cholesterol metabolism.

Glycochenodeoxycholic acid-d7 (sodium) is the deuterated form of Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt, also known as Chenodeoxycholylglycine sodium salt, is a bile salt produced in the liver from chenodeoxycholic acid and glycine. It functions as a detergent to dissolve fats for absorption and is absorbed itself.

Chenodeoxycholic acid-13C is a variant of Chenodeoxycholic Acid marked with 13C. This hydrophobic primary bile acid is capable of activating the nuclear receptor FXR, which is associated with cholesterol metabolism.

Chenodeoxycholic Acid-d4 is a deuterium-labelled compound of Chenodeoxycholic Acid, which can be used for isotopic tracing. CDCA is a bile acid that acts as a detergent to dissolve fats for intestinal absorption.

Chenodeoxycholic acid (Standard) is an analytical reference standard intended for research and quantitative applications, representing a hydrophobic primary bile acid that activates nuclear farnesoid X receptor signaling pathways involved in cholesterol homeostasis, bile acid metabolism, and lipid regulation, and is widely used for biochemical validation, metabolic studies, and analytical method development.

Chenodeoxycholic acid 3-sulfate disodium (Standard) is a reference standard for research and analysis in studies involving Chenodeoxycholic acid 3-sulfate disodium. Chenodeoxycholic acid 3-sulfate disodium is a bile acid and endogenous metabolite used in the study of liver dysfunction.

Chenodeoxycholic Acid-3-Sulfate Sodium Salt (Standard) is a reference standard of Chenodeoxycholic Acid-3-Sulfate Sodium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

Chenodeoxycholic Acid-[D4]-3-Suflate (Standard) is a reference standard of Chenodeoxycholic Acid-[D4]-3-Suflate intended for quantitative analysis, quality control, and related biochemical research applications.

12-Ketochenodeoxycholic acid 12 is a direct precursor of cholodeoxycholic acid (CDCA). 12-Ketochenodeoxycholic acid 12 supports bile acid biosynthesis studies since CDCA is used to dissolve cholesterol gallstones and exhibits chemotherapeutic properties, enabling scientific investigation into bile acid metabolism, gallstone dissolution pathways, and hepatobiliary disease intervention mechanisms with enhanced experimental applicability and translational value.

Chenodeoxycholic acid 3-sulfate disodium is a bile acid and endogenous metabolite used in the study of liver dysfunction.

Isochenodeoxycholic acid (isoCDCA), a bile acid and primary metabolite of ursodeoxycholic acid (UDCA), Isochenodeoxycholic acid exerts protective effects against ethanol-induced damage in HepG2 hepatocytes.

Glycochenodeoxycholic acid sodium salt is a bile salt formed in the liver from deoxycholic acid and glycine that induces apoptosis in hepatocytes. It acts as a detergent, dissolves fats for absorption, and is itself absorbed.

Glycochenodeoxycholic Acid-d4 is a deuterated compound of Glycochenodeoxycholic Acid.

Isochenodeoxycholic Acid-d4 is a deuterated compound of Isochenodeoxycholic Acid. Isochenodeoxycholic Acid has a CAS number of 566-24-5.