ces 2

Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.

HumanCES2Enzyme is a recombinant CES2 enzyme that hydrolyzes carboxylic ester bonds, thioester bonds, and amide bonds in numerous exogenous and endogenous compounds (including lipids).

CES2A-IN-3 (Compound 9d) is a potent covalent inhibitor targeting human carboxylesterase 2A (hCES2A) with an IC50 value of 0.12 nM. It shows promise for research into diarrhea and ulcerative colitis.

Antibiotic ES 242-3 is a useful organic compound for research related to life sciences. The catalog number is T125981 and the CAS number is 136565-68-9.

hCES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible, covalent inhibitor of hCES2A with an IC50 of 0.04 nM. It targets and covalently binds to the catalytic serine residue (Ser-228) of hCES2A. hCES2A-IN-2 can significantly mitigate irinotecan-induced gastrointestinal toxicity (ITGT) without diminishing the antitumor efficacy of irinotecan in tumor-bearing mice.

hCES2-IN-1 (Compound 24) is a reversible and selective inhibitor of the human carboxylesterase 2 (hCES2) enzyme, with an IC50 of 6.72 μM. This compound reduces hCES2 levels in vivo and is effective in treating irinotecan-induced delayed diarrhea and DSS-induced ulcerative colitis [1].

hCES2A-IN-1 (compound 20w), a potent hCES2A inhibitor derived from bysspectin A, exhibits an IC50 value of 1.6 nM, demonstrating an approximately 1000-fold potency enhancement compared to its lead compound, bysspectin A [1].

Isolicoflavonol is a potential cancer chemopreventive agent.

Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).