ceramide

C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.

BODIPY-C12 Ceramide (B12Cer) is a fluorescently-tagged form of C12 ceramide, with excitation/emission maxima at 505/540 nm, respectively. It is a fluorescently-labeled sphingolipid and has been utilized for quantifying acid sphingomyelinase activity in the plasma of patients with Niemann-Pick disease.

C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy.

C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]

C17 dihydro Ceramide (d18:0 17:0) is a lipid molecule that can be used in life science related research. The CAS number of C17 dihydro Ceramide (d18:0 17:0) is 1388156-40-8.

(±)-2'-Hydroxy Ceramide (d18:0/18:0) is a sphingomyelin derivative isolated from mammalian platelets upon ADP stimulation [1].

C12((±)-2'-hydroxy) dihydro Ceramide (d18:0 12:0) is a lipid molecule that can be used in life science related research. The CAS number of C12((±)-2'-hydroxy) dihydro Ceramide (d18:0 12:0) is 2377379-54-7.

C32 Ceramide (d18:1 32:0) is a lipid molecule that can be used in life science related research. The CAS number of C32 Ceramide (d18:1 32:0) is 34227-73-1.

C16((±)-2'-hydroxy) dihydro Ceramide (d18:0 16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16((±)-2'-hydroxy) dihydro Ceramide (d18:0 16:0) is 190249-36-6.

C10 Ceramide (d18:1 10:0) is a lipid molecule that can be used in life science related research. The CAS number of C10 Ceramide (d18:1 10:0) is 111122-57-7.

C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC50 = 18 μM).

C8 PEG-Ceramide, a lipid product, possesses the capability to synthesize lipid bilayer carriers, making it applicable for drug delivery [1] [2].

C16 PEG-Ceramide, a polyethylene glycolylated ceramide, serves as a lipid carrier for delivery and induces autophagy. It is utilized in cancer research [1] [2].

C-6 NBD-dihydro-Ceramide, a biologically active, fluorescent analog of short-chain ceramides, features membrane permeability.

C12-Ceramide (C12 Ceramide (d18:1 12:0)), a ceramide present in the protective membranes surrounding umbilical cord blood vessels in infants born to women with pre-eclampsia, can be used to assess the level of ASM activity in the plasma of patients with Niemann-Pick disease.

Ceramide 1-phosphate, a bioactive lipid, is a critical component of sphingolipids. It plays versatile roles in various cellular behaviors, including differentiation, migration, proliferation, and apoptosis.

A potent modulator of cell proliferation and differentiation.

C6 Ceramide (N-hexanoylsphingosine) is an activator of the ceramide pathway that arrests cells in the G0 G1 phase by activating ERK. It can act in a variety of cancer cell lines.

Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin. It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain. In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi lumen. In mammals, it is biosynthesized by sphingomyelin synthase 2 (SMS2) in the plasma membrane and by sphingomyelin synthase-related protein (SMSr) in the endoplasmic reticulum (ER). In Drosophila, CPE has a role in glial ensheathment of axons. Disrupting CPE synthesis by depleting SMSr in vitro in mammalian cells leads to an accumulation of ER ceramides, which are then mislocalized to the mitochondria, inducing apoptosis. However, ceramide levels are not altered in transgenic mice lacking SMSr catalytic activity. CPEs (bovine) is a mixture of CPEs with variable N-acyl chain lengths.

C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.

Ceramide 1 A is a waxy lipid compound that is a lipid in the top skin layer. It has a special molecular structure because it contains a linoleic acid linked to a long chain omega-hydroxy acid.

C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis.[3]

C2 Ceramide (d14:1 2:0) is a bioactive sphingolipid that, when administered dietarily at 100 μM, induces lipotoxic cardiomyopathy by increasing diastolic and systolic diameter, reducing fractional shortening, and decreasing the number of normal cardiac contractile events in Drosophila.

C16 Ceramide-1-phosphate (d18:1 16:0) ammonium salt (C16 C1P ammonium salt) is an ester product used in synthesizing nanobiomaterials.