calo

Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer.

Ticalopride is a 5-HT3 receptor agonist used in the treatment of digestive disorders, orofacial disorders, otorhinolaryngologic disorders, and may be used in the study of bulimia nervosa, gastroesophageal reflux, and irritable bowel syndrome.

Calophymembranside B is a useful organic compound for research related to life sciences. The catalog number is T124052 and the CAS number is 869285-60-9.

Calopocarpin is a useful organic compound for research related to life sciences. The catalog number is T124691 and the CAS number is 53802-77-0.

Cyclocalopin A is a useful organic compound for research related to life sciences and the catalog number is T124792.

Isocalolongic acid is a useful organic compound for research related to life sciences. The catalog number is T124889 and the CAS number is 40737-92-6.

Prucalopride (R-93877) is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes.

Prucalopride hydrochloride is a selective agonist of the 5-HT4.

Calonyctin A-2b is one of two components of calonyctin A.

Calonyctin A-2d is one of two components of calonyctin.

Caloxin 2A1 TFA is a novel PM Ca2+ pump inhibitor. It inhibits human red blood cell Ca2+-Mg2+-ATPase, blocking Ca2+ dependent formation of a 140-kDa acid-stable acylphosphate.

Taccalonolides C, an anti-cancer agent, exhibits cytotoxic properties by promoting tubulin stabilization, thereby disrupting microtubule dynamics necessary for cancer cell division.

Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+.

Caloxin 2A1 is an inhibitor peptide of the plasma membrane Ca 2+-ATPase (PMCA) responsible for extracellular signaling. Importantly, Caloxin 2A1 has no impact on the basal Mg 2+-ATPase or Na+-K+-ATPase activities.

Caloxin 2A1 acetate is an inhibitor of extracellular plasma membrane Ca2+-ATPase (PMCA) peptide. Caloxin 2A1 acetate inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate.

Prucalopride Succinate (Resolor Succinate) is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively.

Taccalonolide E is a microtubule stabilizer that induces cancer cell apoptosis.

Secalonic acid D, a toxic compound effective against tumor cells, is derived from the metabolites of Aspergillus aculeatus. It operates by activating GSK3-β and degrading β-catenin, consequently down-regulating c-Myc expression, arresting the cell cycle at the G1 phase, and inducing cell apoptosis [1] [2].

Onvitrelin ucalontide ([Phor18-LHRH (338613)]) is a luteinizing hormone-releasing hormone (LHRH) analogue with antineoplastic properties, characterized by the peptide sequence KFAKFAKKFAKFAKKFAKQHWSYGLRPG. It is effective in inhibiting breast, ovarian, and prostate cancer xenografts in mouse models [1] [2].

Caloxin 3A1, a biologically active peptide, is a member of the caloxins, which are inhibitors of the extracellular plasma membrane (PM) Ca2+ pumps. Specifically, it inhibits plasma membrane calcium pumps (PMCAs) without affecting the sarcoplasmic reticulum Ca2+ pump, nor does it inhibit the formation of the acylphosphate intermediate from ATP.

Caloxin 1B1, a bioactive peptide, exhibits selective inhibition of PMCA extracellularly by binding preferentially to the extracellular domain 1 of PMCA4 over PMCA1. Identified through a screening process for its high-affinity interaction with PMCA, Caloxin 1B1 is capable of direct application to cells and tissues, facilitating research into its impact on smooth muscle and endothelium.

Caloxin 1C2 is a specific inhibitor of PMCA (plasma membrane Ca2+-ATPases), displaying selective affinity for PMCA4 over PMCA1, 2, and 3. The Ki values for Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Notably, Caloxin 1C2 does not significantly affect overall Ca2+ transport. Additionally, it impacts the contractile force of coronary arteries.

Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate (ADC) aimed at targeting HER2. It is connected by a linker (XMT-1519 conjugate-1) to an effective payload that includes a STING agonist (STING agonist-20), presenting potential in immune activation and anti-tumor activity.

Calotatug is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.