caffeine

1-Methylxanthine is a caffeine derivative. 1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.

8-Chloro caffeine binds to adenosine receptors with a Ki of 30 µM. It enhances UV-induced chromosomal aberrations in the Cl-I type Chinese hamster embryo lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine.

Caffeine N-Acetyl-L-Tryptophan is a caffeine salt that stimulates the nervous system and causes vasodilation.

1,3,7-Trimethyluric acid, a purine alkaloid, occurs as a minor metabolite of caffeine in humans. It functions as an antioxidant with the ability to scavenge hydroxyl radicals and offers protective benefits against lipid peroxidation in erythrocyte membranes.

G-33378 is a metabolite of sulfinpyrazone that inhibits human platelet cyclo-oxygenase activity.

6-Thiocaffeine is a bioactive chemical.

Isocaffeine is a useful organic compound for research related to life sciences. The catalog number is T65260 and the CAS number is 519-32-4.

Salicylamide (2-Hydroxybenzamide) is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In the over-the-counter pain remedies, Salicylamide is used in combination with both aspirin and caffeine.

(R)-(+)-Citronellal ((+)-Citronellal) is a monoterpene compound isolated from citrus, lavender, and eucalyptus oils. It has antifungal activity and reduces the bitterness of caffeine by inhibiting bitter receptors TAS2R43 and TAS2R46. It is commonly used in skincare products.

Cofpropamine, a caffeine derivative that inhibits polyadenylation, enhances the suppressive effects of Cyclophosphamide in animal models of rat adjuvant arthritis and mouse collagen-induced arthritis.

DMPX (3,7-Dimethyl-1-propargylxanthine) is a caffeine-like compound capable of crossing the blood-brain barrier. It serves as an A2-selective adenosine receptor (AR) antagonist, effectively and selectively blocking the hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists, such as NECA. DMPX is utilized in research on diseases like Parkinson's disease.

Cafaminol (methylcoffanolamine) is a vasoconstrictor and anticatarrhal of the methylxanthine family related to caffeine which is used as a nasal decongestant.

7-Methyluric Acid is a metabolite of caffeine produced by xanthine oxidase and detectable in urine.

1,7-Dimethyluric acid is a metabolite of caffeine that serves as a biomarker for caffeine intake and can be detected in urine.

Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is structurally similar to caffeine and possibly mediates the physiological effects of caffeine. Also Paraxanthine acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-α and leukotriene synthesis. In addition, Paraxanthine acts as a Na+/K+ ATPase enzymatic effector.

1,3,7-Trimethyluric Acid-D9 is intended for use as an internal standard for the quantification of 1,3,7-Trimethyluric Acid (T19792) by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.

Paraxanthine-D6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine (T4973) is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine (T4973) is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agonist CPA or the adenosine A2 receptor agonist CGS 21680 in rats not habituated to caffeine. It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.

Theobromine-D6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine (T0625) is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine (T0625) increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium. It inhibits decreases in renal cortex SIRT1 activity and increases in NADPH oxidase-dependent reactive oxygen species (ROS) production, as well as reduces kidney hypertrophy and albuminuria in a spontaneously hypertensive rat model of streptozotocin-induced diabetes when administered at a dose of 5 mg/kg per day.3 Theobromine (T0625) is toxic to dogs with an LD50 value of 250 to 500 mg/kg.

Azumolene sodium anhydrous is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. Azumolene, an equipotent dantrolene analog, inhibits a component of SOCE coupled to activation of RyR1 by caffeine and ryanodine, whereas the SOCE component induced by thapsigargin is not affected.

ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pulmonary vein arrhythmogenesis and atrial fibrillation [1] [2]. It exhibits interaction with halothane, caffeine, and ryanodine.

ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the sea anemone (Anemonia sulcata). This compound impedes the inactivation of Na+ channels and has been associated with arrhythmogenesis in the pulmonary vein and atrial fibrillation [1] [2]. It interacts with halothane, caffeine, and ryanodine in this modulation.

Paraxanthine-D6 (Standard) is a reference standard of Paraxanthine-D6 intended for quantitative analysis, quality control, and related biochemical research applications. Paraxanthine-d6 is used as an internal standard substance for the quantitative determination of Paraxanthine by gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS). Paraxanthine is an active metabolite of caffeine.

AAMU is a metabolite of Caffeine.

Methylliberine is a natural purine alkaloid structurally similar to caffeine and theophylline, primarily derived from plants of the genus Coffea and certain species of the Theaceae family. By modulating adenosine receptor-related signaling, it influences central nervous system stimulation, attention, and energy metabolism, and is used in research related to sports nutrition and functional foods.