c 48

NSC368262 is a selective Stat3-family member inhibitor. NSC368262 alkylates Cys468 in Stat3.

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde produced via a condensation reaction. It acts as a mast cell degranulator and histamine releaser and inhibits phosphatidylinositol-specific phospholipase C activity in human platelets.

EOP (t18:0/30:0/18:2) (C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine) is a phytoceramide-based compound resembling EOS. This compound is synthesized by esterifying ω-hydroxy very long-chain ceramides (C28-36) with the essential fatty acid linoleic acid. EOP (t18:0/30:0/18:2) has been utilized as a component in models of stratum corneum lipid mixtures.

The Anti-MUC1/CD227 Antibody (C595 (NCRC48)) is a chimeric mouse IgG3, κ antibody targeting human MUC1/CD227. Its isotype control is the Mouse IgG3 kappa, Isotype Control.

KRAS G12C Inhibitor 48 is a potent inhibitor targeting the KRAS G12C mutation, exhibiting an IC50 value of 639.91 nM. Demonstrating antiproliferative activity, KRAS G12C Inhibitor 48 (0-50 µM) yields IC50 values of 0.796 µM, 6.33 µM, and 16.14 µM against H358, H23, and A549 cell lines, respectively.

NSC 4810 is an amide bioactive compound that has been used as a substrate for cytochrome P450 enzymes in vivo and as a substrate for acetylcholinesterase in vitro.

AC 485 is a biochemical.

NSC 48160 is a small molecule compound with anti-pancreatic cancer activity that inhibits the growth of pancreatic cancer cells, induces apoptosis of pancreatic cancer cells through the mitochondrial pathway and inhibits metastasis of two types of pancreatic cancer cells in vitro, and can freeze the intermediate of Ras-GTP hydrolysis in the open non-signaling conformation with high affinity and high specificity in silico.

Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. [1] Osunprotafib (ABBV-CLS-484) stimulates the tumor microenvironment and promotes natural killer cell and CD8 T cell function and enhances T cell anti-tumor immunity by enhancing JAK-STAT signaling and reducing T cell dysfunction. [2]

ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the chemotherapy of cancer, and provide a rationale for developing pathway-specific p97 inhibitors.

BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.

N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and C481S BTK, which can be used to synthesize a range of PROTAC molecules.N-piperidine Ibrutinib hydrochloride has potential anticancer N-piperidine Ibrutinib hydrochloride has potential anticancer activity, inhibiting the growth and proliferation of cancer cells.

SPR719 is an inhibitor of gyrase B, has bactericidal activity.

ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

NMS-873 is a potent and selective allosteric inhibitor of VCP/p97.

SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.

DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.

N-Butyl stearate (NSC-4820，Stearic acid butyl ester) is an oily organic reagent that is an excellent PVC internal lubricant for organic synthesis.

UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.

BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.

BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor response to radiotherapy.

Ethimidine is an antineoplastic.

IMC-48, as a BCL2 i-motif-interactive compound, can act by stabilizing or facilitating the folding of the i-motif.

SC-48274 is a novel anxiolytic. SC-48274 has anxiolytic activity of the same potency as buspirone and repeated-dose administration is needed to induce anxiolytic acitivity.