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antiprion

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    10
    TargetMol | Inhibitors_Agonists
TCS PrP Inhibitor 13
5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One
T2345034320-83-7
TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.
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TargetMol | Inhibitor Sale
l-Atabrine dihydrochloride
T1180156100-42-6
l-Atabrine dihydrochloride displays antiprion activity. l-Atabrine dihydrochloride is a less active enantiomer of quinacrine.
    7-10 days
    Inquiry
    1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one
    T20173760798-06-3
    1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one (Compound 2) exhibits antiprion activity in ScN2a and F3 cells, with IC50 values of 13 nM and 25 nM, respectively.
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    10-14 weeks
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    IND81
    IND-81,IND 81
    T255321426047-52-0
    IND81 is an antiprion agent that works by extending the lives of prion-infected animals.
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    6-8 weeks
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    IND45193
    IND-45193,IND 45193
    T2760510024-04-1
    IND45193, an antiprion agent, acts by reducing PrP(Sc) levels in dividing and stationary-phase cells.
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    6-8 weeks
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    Chloroguanabenz (acetate)
    T38146
    Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both soluble and aggregated forms of the truncated Huntingtin derivative Htt48 in an HEK293T cellular model of Huntington's disease.
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    6-Amino-8-trifluoromethylphenanthridine
    T38186651055-83-3
    6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine. It inhibits the protein folding activity of the ribosome (PFAR) at a concentration of 150 μM and directly competes with protein substrates for the ribosomal active site.
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    6-Aminophenanthridine
    T38187832-68-8
    6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz . 6-Aminophenanthridine (300 μM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate. It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 μM and in adults following dietary administration of 1-3 mM doses. 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.
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    6-8 weeks
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    Quinoprazine
    T61651115618-99-0
    Quinoprazine, a powerful inhibitor of Vaccinia virus DNA synthesis (IC50 = 10 μM), exhibits notable antimalarial activity against Plasmodium berghei. Additionally, it demonstrates significant antiprion potency, effectively reducing levels of PrPSc [1]-[5].
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    6-8 weeks
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    BiCAPPA
    T73416119662-55-4
    BiCAPPA, a pioneering bivalent antiprion ligand, effectively reduces the infectious conformational form of prion protein (PrP Sc) in scrapie-infected cells, achieving this at a concentration (EC 50) of 0.32 μM.
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