Search Result

Search Results for " anti-diabetic "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T8345	Carbutamide		Others
	Carbutamide is a sulfonylurea antidiabetic agent with hypoglycemic activity.		Others
T7704	KY-226		Phosphatase
	KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)		Phosphatase
T9921	Infliximab		TNF
	Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.		TNF
T2316	Omarigliptin	MK-3102	Proteasome , DPP-4
	Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.		Proteasome , DPP-4
T6237	Trelagliptin	SYR-472	Proteasome , DPP-4
	Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.		Proteasome , DPP-4
T8408	GKT136901	AK120765	NADPH-oxidase , NADPH
	GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite		NADPH-oxidase , NADPH
T6587	Mitiglinide Calcium	KAD-1229,S21403	ATPase , Potassium Channel
	Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.		ATPase , Potassium Channel
T2296	Trelagliptin succinate	SYR-472 succinate,SYR472	Proteasome , DPP-4
	Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2D).		Proteasome , DPP-4
T1530	Mitiglinide calcium hydrate	KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate	Potassium Channel
	Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic ...		Potassium Channel
T37890L	GLP-1(28-36)amide acetate	GLP-1(28-36)amide acetate(1225021-13-5 Free base)	Antioxidant , Glucagon Receptor
	GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.		Antioxidant , Glucagon Receptor
T34485	Safotibant	LF220542,LF 220542,LF 22-0542,LF-220542,LF-22-0542,LF22-0542	Bradykinin Receptor
	Safotibant (LF-22-0542) is a bradykinin B1 receptor antagonist with anti-inflammatory and analgesic activity for the topical treatment of diabetic macular edema.		Bradykinin Receptor
T7298	FT011		Others
	FT011, a direct anti-fibrotic agent,attenuates cardiac remodelling and dysfunction in experimental diabetic cardiomyopathy.		Others
T2650	MK-8245		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
	MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
TP1761L	Handle region peptide, rat acetate	Handle region peptide, rat acetate(749227-53-0 free base)	Others
	Handle region peptide, rat acetate is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.		Others
T0740	Metformin hydrochloride	Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride	Mitophagy , AMPK , Autophagy
	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro...		Mitophagy , AMPK , Autophagy
T22276	Bis(maltolato)oxovanadium(IV)	BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)	Phosphatase , Others
	Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent i...		Phosphatase , Others
T23046	N-tert-butyl-α-Phenylnitrone	(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide	ROS , COX
	N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxyge...		ROS , COX
T0242	Sitagliptin	MK0431	Proteasome , DPP-4 , Autophagy
	Sitagliptin (MK0431), a new oral hypoglycemic (anti-diabetic drug), is a new dipeptidyl peptidase-4 (DPP-4) inhibitor. This enzyme-inhibiting drug is used either alone or in combination with metformin or thiazolidinedion...		Proteasome , DPP-4 , Autophagy
T1603	Glipizide	CP 28720,K 4024	Potassium Channel , PPAR , ABC
	Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.		Potassium Channel , PPAR , ABC
T12848	SB-657510		Others , Neurotensin Receptor
	SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting U...		Others , Neurotensin Receptor
T10362	AR453588		Others
	AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.		Others
T24486	MLR24	MLR 24,MLR-24
	MLR24 is a selective modulator of PPARγ that acts by displaying robust anti-diabetic activity.
T10362L	AR453588 hydrochloride		Others
	AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.		Others
T26661	AS1708727
	AS1708727 is a Foxo1 inhibitor, exerting anti-hypertriglyceridemic and anti-diabetic effects by improving triglyceride and blood glucose metabolism at the gene expression level.
T30472	Bisegliptin	KRP-104	Others
	Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.		Others
T15166	DPM-1001		Phosphatase
	DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.		Phosphatase
T17094	Tifenazoxide	NN414	Others
	Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.		Others
TP1761	Handle region peptide, rat
	Handle region peptide, rat, functions as a prorenin receptor antagonist, effectively inhibiting the development of diabetic nephropathy while also exhibiting anti-inflammatory properties specifically within the eye.
T69304	MRL20
	MRL20 is a selective PPARγ modulator (SPPARγM) which displays robust anti-diabetic activity with an improved therapeutic window in comparison to a PPARγ full agonist in a rodent efficacy model.
T10752	Ceftezole	CTZ	Others
	Ceftezole is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. It is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria.		Others
T23040	N-Arachidonylglycine		Others
	N-Arachidonylglycine is a biologically active lipid molecule that belongs to arachidonic acid derivatives. It has a wide range of biological activities including anti-inflammatory, anti-cancer, anti-diabetic and antioxid...		Others
T61761	α-Glucosidase-IN-21
	α-Glucosidase-IN-21 (Compound 2B) is a highly potent and orally bioavailable inhibitor of α-glucosidase. With an impressive IC50 value of 2.62 μM, this compound exhibits remarkable anti-diabetic properties [1].
T61331	α-Glucosidase-IN-20
	α-Glucosidase-IN-20 (Compound 3B) is a highly effective and orally active inhibitor of α-glucosidase. It exhibits potent anti-diabetic properties, as evidenced by its IC50 value of 3.01 μM [1].
T69603	BR103354
	BR103354 is a novel fibroblast activation protein (FAP) inhibitor with anti-diabetic and anti-steatotic effects. BR103354 inhibited FAP with an IC50 value of 14 nM, showing high selectivity against dipeptidyl peptidase (...
T63310	α-Glucosidase-IN-6
	α-Glucosidase-IN-6 is a competitive inhibitor of α-glucosidase (IC50: 5.69 μM) and exhibits potential for anti-diabetic studies.
T70005	LY3325656
	LY3325656 is a GPR142 agonist suitable for clinical testing in human. LY3325656 demonstrated anti-diabetic benefits in pre-clinical studies and ADME/PK properties suitable for human dosing. LY3325656 is the first GPR1...
T74867	UBX1325
	UBX1325, a Bcl-xL inhibitor, enhances apoptosis in senescent cells, serving as an effective anti-aging agent. It holds potential for age-related eye disease research, including diabetic macular oedema (DME), age-related ...
T79259	α-Glucosidase-IN-25		Glucosidase
	α-Glucosidase-IN-25 (Compound (R)-8k) serves as a competitive inhibitor for α-glucosidase, demonstrating an inhibitory concentration 50 (IC50) of 1.19μM, making it applicable in anti-diabetic research [1].		Glucosidase
T38646	GKT136901 hydrochloride	GKT136901 hydrochloride
	GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochlor...
T37827	CAY10506	CAY10506
	Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism ...
T37890	GLP-1(28-36)amide
	GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it ef...
T62951	Aldose reductase-IN-2
	Aldose reductase-IN-2 (Compound 5f) is a potent inhibitor of aldose reductase (AR) with antioxidant properties. aldose reductase-IN-2 is a promising anti-diabetic complication drug.
T72216	DPM-1001 trihydrochloride
	DPM-1001 trihydrochloride, an analog of the specific protein-tyrosine phosphatase (PTP1B) inhibitor MSI-1436, is a potent, specific, non-competitive, orally active inhibitor of PTP1B with an IC50 of 100 nM, exhibiting an...
T76191	GLP-1(28-36)amide TFA
	GLP-1(28-36)amide TFA, a C-terminal nonapeptide derived from GLP-1 cleavage by neutral endopeptidase (NEP), acts as an antioxidant targeting mitochondria. It inhibits mitochondrial permeability transition (MPT), exhibiti...
T35812	CAY10591	CAY10591
	Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the...
T38844	MK-8245 Trifluoroacetate
	MK-8245 trifluoroacetate is a phenoxy piperidine isoxazole derivative functioning as a potent, liver-targeting stearoyl-CoA desaturase (SCD) inhibitor, demonstrating significant anti-diabetic and anti-dyslipidemic effect...
T35802	ML-345
	Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin a...
T35816	ZLY032
	ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and...

Compounds

Target: Proteasome, DPP-4

Trelagliptin

T6237

Synonym: SYR-472

Target: Proteasome, DPP-4

GKT136901

T8408

Synonym: AK120765

Target: NADPH-oxidase, NADPH

Mitiglinide Calcium

T6587

Synonym: KAD-1229,S21403

Target: ATPase, Potassium Channel

Trelagliptin succinate

T2296

Synonym: SYR-472 succinate,SYR472

Target: Proteasome, DPP-4

Mitiglinide calcium hydrate

T1530

Synonym: KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate

Target: Potassium Channel

GLP-1(28-36)amide acetate

T37890L

Synonym: GLP-1(28-36)amide acetate(1225021-13-5 Free base)

Target: Antioxidant, Glucagon Receptor

Safotibant

T34485

Synonym: LF220542,LF 220542,LF 22-0542,LF-220542,LF-22-0542,LF22-0542

Target: Bradykinin Receptor

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Handle region peptide, rat acetate

TP1761L

Synonym: Handle region peptide, rat acetate(749227-53-0 free base)

Target: Others

Metformin hydrochloride

T0740

Synonym: Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride

Target: Mitophagy, AMPK, Autophagy

Bis(maltolato)oxovanadium(IV)

T22276

Synonym: BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)

Target: Phosphatase, Others

N-tert-butyl-α-Phenylnitrone

T23046

Synonym: (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide

Target: Proteasome, DPP-4, Autophagy

Glipizide

T1603

Synonym: CP 28720,K 4024

Target: Potassium Channel, PPAR, ABC

SB-657510

T12848

Synonym:

Target: Others, Neurotensin Receptor

Synonym: MLR 24,MLR-24

Target:

AR453588 hydrochloride

Handle region peptide, rat

GKT136901 hydrochloride

T38646

Synonym: GKT136901 hydrochloride

Aldose reductase-IN-2

T62951

Synonym:

Target:

DPM-1001 trihydrochloride

T72216

Synonym:

Target:

GLP-1(28-36)amide TFA

MK-8245 Trifluoroacetate

Cat No.	Product Name	Synonyms	Targets
TN6490	Regaloside C		Others
	Regaloside C is a glycerol glucoside isolated from Lilium genus with anti-inflammatory properties.		Others
TN1686	Ginsenoside Rg4		Antibacterial
	Ginsenoside Rg4 is a natural product		Antibacterial
TN1644	Flavanomarein		Others
	Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea...		Others
T7792	Hispidin		Endogenous Metabolite , PKC
	Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties		Endogenous Metabolite , PKC
T3803	Specnuezhenide	Nuzhenide,Nuezhenide	Others , NF-κB , Wnt/beta-catenin
	Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t...		Others , NF-κB , Wnt/beta-catenin
T2755	Rhoifolin	Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others , p38 MAPK , NF-κB , transporter , IGF-1R , Autophagy
	Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.
TN7108	Urolithin C		Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite
	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
TN2111	Prunin	Naringenin 7-0-glucoside	Phosphatase , Anti-infection , Virus Protease
	Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can...		Phosphatase , Anti-infection , Virus Protease
T2S1158	4,5-Dicaffeoylquinic acid	3,4-Dicaffeoylquinic acid,Isochlorogenic acid C	Others , HBV , Endogenous Metabolite
	1. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) has antiviral activity, including anti-HIV-1 integrase activity. 2. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) shows anti-hepatotoxic activity.		Others , HBV , Endogenous Metabolite
TN6774	Emodin 6-O-β-D-glucoside	Glucoemodin	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ...		Others
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T7026	KukoaMine B		Antioxidant
	Kukoamine B, as a constituent of Lycii Cortex, exhibits anti-acute inflammatory, anti-oxidant, and anti-diabetic characteristics.		Antioxidant
T7986	Methyl tetracosanoate		Others
	Methyl tetracosanoate is a natural product, with anti-diabetic activity.		Others
T2741	Glycyrrhizic acid	Glycyrrhizin	Virus Protease , Dehydrogenase , MAO
	Glycyrrhizic acid (Glycyrrhizin) is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.		Virus Protease , Dehydrogenase , MAO
T6S1367	Procyanidin B2	Proanthocyanidin B2	Reactive Oxygen Species , NOD
	Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression ...		Reactive Oxygen Species , NOD
TN1308	6-Hydroxyflavanone		Others , Lipoxygenase , COX , GABA Receptor
	6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r...		Others , Lipoxygenase , COX , GABA Receptor
T5708	LUPENONE		Phosphatase , Parasite
	Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhibitors with IC50 values of 15.11±1.23μM.		Phosphatase , Parasite
TN1406	Dihydrokaempferol	Aromadendrin	Apoptosis , BCL
	Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory ...		Apoptosis , BCL
T7600	Fucoxanthin	all-trans-Fucoxanthin	Others
	Fucoxanthin (all-trans-Fucoxanthin) is a carotenoid that occurs naturally in certain algae. It is found as an accessory pigment in the chloroplasts of brown algae and most other heterokonts, giving them a brown or olive-...		Others
T8184	Fucosterol		PARP , Endogenous Metabolite , PPAR
	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.		PARP , Endogenous Metabolite , PPAR
T4S0295	Apigenin 7-glucoside	Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,Thalictiin,Apigetrin	Reactive Oxygen Species , HIV Protease
	1. Apigenin 7-glucoside (Cosmosiin) is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 tr...		Reactive Oxygen Species , HIV Protease
TN2130	Manghaslin	Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside	AChE , Glucosidase
	Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also shows inhibito...		AChE , Glucosidase
TN1020	Monomelittoside	Danmelittoside	Others
	Monomelittoside (Danmelittoside), a compound extracted from the venom of the Chinese honeybee, is a flavonoid glycoside that has been found to have anti-inflammatory, anti-tumor and anti-diabetic properties. It has also ...		Others
T2212	Geniposide		Beta Amyloid , Influenza Virus
	Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation...		Beta Amyloid , Influenza Virus
T2740	Trans-Cinnamic acid	Isocinnamic acid,Cinnamic acid,trans-3-Phenylacrylic acid,Phenylacrylic acid,Cinnamylic acid,3-Phenylacrylic acid,Myricitrine	Endogenous Metabolite , Antibacterial
	trans-Cinnamic acid (Myricitrine) exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro.		Endogenous Metabolite , Antibacterial
TN1134	Euscaphic acid		Apoptosis , LDL , PI3K , DNA/RNA Synthesis , NO Synthase , Prostaglandin Receptor
	Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of...
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine	(4S)-4-Hydroxy-L-isoleucine,Hydroxyisoleucine	PI3K
	(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secr...		PI3K
T3S0381	Chrysophanol 8-O-glucoside		Serine Protease
	Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway		Serine Protease
T3823	D-Pinitol	Pinitol,Inzitol,D-(+)-Pinitol,Methylinositol,3-O-Methyl-D-chiro-inositol	Others , Influenza Virus
	D-Pinitol (Methylinositol) has anti-inflammatory activity. D-Pinitol(Methylinositol) exerts insulin-like activity, used for many diabetic associated conditions. D-Pinitol(Methylinositol) is a safe nutrient to reduce calo...		Others , Influenza Virus
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
T3849	Kinsenoside	(+)-Kinsenoside	Apoptosis , Nrf2
	Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it cou...		Apoptosis , Nrf2
TN1042	Chebulic acid		Others
	Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits t...		Others
T3414	Morroniside		Apoptosis , MMP , Pyroptosis
	Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib...		Apoptosis , MMP , Pyroptosis
T5S1172	Tiliroside	Tribuloside	Antioxidant
	1. Tiliroside (Tribuloside) shows anticarcinogenic activity. 2. Tiliroside shows hepatoprotective activity. 3. Tiliroside shows antioxidant and anti-inflammatory activity, can inhibit neuroinflammation in neurodegenerati...		Antioxidant
T5S1097	Neferine	(R)-1,2-Dimethoxyaporphine,(-)-Neferine	Apoptosis , NF-κB , Autophagy
	1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to a...		Apoptosis , NF-κB , Autophagy
TN2601	12-O-Methylcarnosic acid		Reductase
	12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity...		Reductase
T3753	Sinapinic Acid	Sinapic acid,Synapoic acid	Apoptosis , RAAS , Reactive Oxygen Species , HDAC
	Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap...		Apoptosis , RAAS , Reactive Oxygen Species , HDAC
T3794	Pentagalloylglucose	Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose	Influenza Virus
	1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses poten...		Influenza Virus
T22541	Acarbose sulfate		Others
	Acarbose sulfate is an anti-diabetic drug and is an inhibitor of alpha-glucosidase.		Others
T40584	Corymbiferin
	Corymbiferin, a chemical compound, exhibits significant anti-diabetic properties by enhancing antioxidant capacity and carbohydrate metabolism in diabetic rodents. In addition, Corymbiferin promotes the improvement of hi...
TN1940	Momordicine I		Others
	Momordicine I has anti-diabetic and antifeedant activities.		Others
T40977	Cinnamtannin A2
	Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone. Additionally, Cinnamtannin A2 exhibits antioxidant, anti...
T10183	6-Methoxytricin		Others
	6-Methoxytricin is a flavonoid isolated from Artemisia iwayomogi. It is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities (IC50s: 30.29 μM and 134.88 μM). 6-Methoxytricin ...		Others
TN3532	Borapetoside E		Others
	Borapetoside E has anti-hyperglycemic activity, it can significantly reduce serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.		Others
TN5149	Tirotundin		NF-κB , COX , PPAR
	Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory me...		NF-κB , COX , PPAR
T75532	Cirsiliol 4′-glucoside
	Cirsiliol 4′-glucoside, a compound extracted from Ruellia tuberosa L., acts as a free radical scavenger and demonstrates potential anti-diabetic activity [1].
T77201	Rutin trihydrate
	Rutin (Rutoside) trihydrate, a natural flavonoid glycoside, exhibits multifaceted therapeutic properties, including antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic activities. Additionally, it has de...
TN1681	Gentianine		Others , TNF , transporter , PPAR
	Gentianine is an effective Swertiamarin derivative, which has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, diuretic and other effects, and has the potential to be developed into a safe antihypertensive d...		Others , TNF , transporter , PPAR
TN4094	Gallocatechin gallate		IL Receptor , NF-κB , ROS , MAPK , PPAR , Fatty Acid Synthase
	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-ÎºB signaling; it also may have anti-diabeti...
TN5091	Tagitinin A		PPAR , Antifection
	Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the growth of STS and weeds. Tagitinin A is also a PPARα/γ dual ...		PPAR , Antifection
------------------------ More ------------------------

Natural Products

Target: Antibacterial

Target: Endogenous Metabolite, PKC

Specnuezhenide

T3803

Synonym: Nuzhenide,Nuezhenide

Target: Others, NF-κB, Wnt/beta-catenin

Rhoifolin

T2755

Synonym: Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside

Target: Others, p38 MAPK, NF-κB, transporter, IGF-1R, Autophagy

Urolithin C

TN7108

Synonym:

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, IGF-1R, Endogenous Metabolite

Prunin

TN2111

Synonym: Naringenin 7-0-glucoside

Target: Phosphatase, Anti-infection, Virus Protease

4,5-Dicaffeoylquinic acid

T2S1158

Synonym: 3,4-Dicaffeoylquinic acid,Isochlorogenic acid C

Target: Others, HBV, Endogenous Metabolite

Emodin 6-O-β-D-glucoside

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

KukoaMine B

T7026

Synonym:

Target: Antioxidant

Methyl tetracosanoate

Synonym: Glycyrrhizin

Target: Virus Protease, Dehydrogenase, MAO

Procyanidin B2

T6S1367

Synonym: Proanthocyanidin B2

Target: Reactive Oxygen Species, NOD

6-Hydroxyflavanone

TN1308

Synonym:

Target: Others, Lipoxygenase, COX, GABA Receptor

LUPENONE

T5708

Synonym:

Target: Phosphatase, Parasite

Dihydrokaempferol

TN1406

Synonym: Aromadendrin

Target: Apoptosis, BCL

Fucoxanthin

T7600

Synonym: all-trans-Fucoxanthin

Target: PARP, Endogenous Metabolite, PPAR

Apigenin 7-glucoside

T4S0295

Synonym: Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,Thalictiin,Apigetrin

Target: Reactive Oxygen Species, HIV Protease

Manghaslin

TN2130

Synonym: Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside

Target: AChE, Glucosidase

Monomelittoside

TN1020

Synonym: Danmelittoside

Target: Beta Amyloid, Influenza Virus

trans-Cinnamic acid

T2740

Synonym: Isocinnamic acid,Cinnamic acid,trans-3-Phenylacrylic acid,Phenylacrylic acid,Cinnamylic acid,3-Phenylacrylic acid,Myricitrine

Target: Endogenous Metabolite, Antibacterial

Euscaphic acid

TN1134

Synonym:

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

(2S,3R,4S)-4-Hydroxyisoleucine

T2P2919

Synonym: (4S)-4-Hydroxy-L-isoleucine,Hydroxyisoleucine

Target: PI3K

Chrysophanol 8-O-glucoside

T3S0381

Synonym:

Target: Serine Protease

D-Pinitol

T3823

Synonym: Pinitol,Inzitol,D-(+)-Pinitol,Methylinositol,3-O-Methyl-D-chiro-inositol

Target: Others, Influenza Virus

Obtusifolin

T4S0969

Synonym:

Target: Antioxidant, NF-κB

Kinsenoside

T3849

Synonym: (+)-Kinsenoside

Target: Apoptosis, Nrf2

Target: Apoptosis, MMP, Pyroptosis

Tiliroside

T5S1172

Synonym: Tribuloside

Target: Antioxidant

Neferine

T5S1097

Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine

Target: Apoptosis, NF-κB, Autophagy

12-O-Methylcarnosic acid

Synonym: Sinapic acid,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Pentagalloylglucose

T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose

Target: Influenza Virus

Target: NF-κB, COX, PPAR

Cirsiliol 4′-glucoside

Target: Others, TNF, transporter, PPAR

Gallocatechin gallate

TN4094

Synonym:

Target: IL Receptor, NF-κB, ROS, MAPK, PPAR, Fatty Acid Synthase

Tagitinin A

TN5091

Synonym:

Target: PPAR, Antifection

--------- More ---------

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02848	Adiponectin Protein, Human, Recombinant (hFc)	Human	HEK293
	Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other t...
TMPY-05556	Adiponectin Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other t...
TMPK-00554	Adiponectin Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation.Important adipokine involved in the control of fat metabolism and insuli...
TMPK-00139	Adiponectin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation.Important adipokine involved in the control of fat metabolism and insuli...
TMPH-00219	Adiponectin Protein, Bovine, Recombinant (His)	Bovine	Yeast
	Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the l...
TMPH-03760	NAMPT Protein, Mouse, Recombinant	Mouse	E. coli
	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev...
TMPH-02810	NAMPT Protein, Mouse, Recombinant (His)	Mouse	Yeast
	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev...
TMPH-03761	NAMPT Protein, Mouse, Recombinant (HA & His)	Mouse	E. coli
	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev...
TMPY-01681	Adiponectin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other t...
TMPY-00186	GHRH Protein, Human, Recombinant (hFc)	Human	HEK293
	The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important...