aldosterone synthase

Osilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) with IC50 values ​​of 2.5 and 0.7 nM, respectively, and has been approved by the FDA for the treatment of Cushing's disease.

Baxdrostat is an aldosterone synthase inhibitor.

Lorundrostat (MT-4129) is an aldosterone synthase inhibitor with antihypertensive activity that lowers systolic blood pressure.

BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively).

AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.

Dexfadrostat is an effective non-steroidal inhibitor of aldosterone synthase (CYP 11B2).

18-Oxocortisol is a cortisol derivative generated by aldosterone synthase (CYP11B2). It acts as a naturally occurring mineralocorticoid agonist and serves as a biomarker in adrenal vein sampling.

(S)-Baxdrostat is an S-enantiomer of Baxdrostat, which functions as an inhibitor of aldosterone synthase [1].

CYP19A1/CYP11B2-IN-1 is a potent dual inhibitor of aromatase (CYP19A1) and aldosterone synthase (CYP11B2), with IC₅₀ values of 2.3 nM and 29 nM, respectively. CYP19A1/CYP11B2-IN-1 inhibits breast cancer cell proliferation and induces apoptosis (IC₅₀ of 0.26 ± 0.03 μM against MCF-7 cells). CYP19A1/CYP11B2-IN-1 downregulates the PI3K/Akt/mTOR signaling pathway by inhibiting mTOR phosphorylation.

Vicadrostat is an inhibitor of aldosterone synthase (IC50=48 nM) that is used in research related to kidney and cardiovascular diseases.

AldoView precursor-1 (Compound 7) is the essential labeled precursor for synthesizing the radioactive PET tracer [18F] AldoView. This tracer is a selective PET imaging agent for aldosterone synthase, and it is applied in the imaging of primary aldosteronism.

AldoView (Compound 3) is an intermediate that can be labeled with fluorine-18 to synthesize [18F]AldoView. This compound serves as a highly selective aldosterone synthase PET imaging agent. AldoView is utilized in imaging studies for primary aldosteronism.