aldosterone synthase

Lorundrostat (MT-4129) is an aldosterone synthase inhibitor with antihypertensive activity that lowers systolic blood pressure.

Baxdrostat is an aldosterone synthase inhibitor.

AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.

18-Oxocortisol is a cortisol derivative generated by aldosterone synthase (CYP11B2). It acts as a naturally occurring mineralocorticoid agonist and serves as a biomarker in adrenal vein sampling.

(S)-Baxdrostat is an S-enantiomer of Baxdrostat, which functions as an inhibitor of aldosterone synthase [1].

Compound X21 (CYP19A1 CYP11B2-IN-1) is a potent dual inhibitor of aromatase (CYP19A1) and aldosterone synthase (CYP11B2), with IC50 values of 2.3 nM and 29 nM, respectively. It exhibits strong antiproliferative and pro-apoptotic effects on cancer cells. Compound X21 is suitable for breast cancer research purposes [1].

BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively).

Osilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) with IC50 values ​​of 2.5 and 0.7 nM, respectively, and has been approved by the FDA for the treatment of Cushing's disease.

Dexfadrostat is an effective non-steroidal inhibitor of aldosterone synthase (CYP 11B2).

Vicadrostat is an inhibitor of aldosterone synthase (IC50=48 nM) that is used in research related to kidney and cardiovascular diseases.