adcs toxin

(+)-CBI-CDPI1, an enhanced functional analog of CC-1065, is a DNA alkylating agent and an antibody-drug conjugate (ADCs) toxin.

Duocarmycin MA, an antibody drug conjugates (ADCs) toxin, is a DNA alkylating agent that binds in the minor groove and can be used against multi-drug resistant cell lines.

Duocarmycin MB, an antibody-drug conjugate (ADCs) toxin, is a DNA alkylating agent that binds in the minor groove and can be used against multi-drug resistant cell lines.

alpha-Amanitin (alpha-Amanitin) is the lethal toxin in Trichoderma viride and acts in vivo via the enterohepatic circulation and transport system. alpha-Amanitin induces cell death and can be used in the synthesis of ADCs. alpha-Amanitin has been shown to induce cell death and can be used in the synthesis of ADCs.

PNU-159682, a metabolite of anthracycline neomycin, is a DNA topoisomerase II inhibitor with excellent cytotoxicity.

Mal-PEG4-VC-PAB-DMEA-duocarmycin-DM is a thiol-reactive Drug-linker. Duocarmycin DM is a DNA alkylating agent that can be used as a toxin for ADC conjugates and is employed in the synthesis of antibody-drug conjugates (ADCs).

7-MAD-MDCPT, a Camptothecin analog, serves as a toxin payload in antibody-drug conjugates (ADCs).

MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).

Duocarmycin DM, a toxin for antibody-drug conjugates (ADCs), functions as a DNA minor-groove alkylator. It exerts its anticancer activity through a distinct curved indole structure combined with a spirocyclopropylcyclohexadienone electrophile [1] [2].

Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].

MYX1715 is an inhibitor of N-myristoyltransferase (NMT), exhibiting a KD of 0.09 nM. It inhibits the proliferation of LU0884 and LU2511, with IC50 values of 44 nM and 9 nM, respectively. In mouse models, MYX1715 demonstrates antitumor activity against neuroblastoma and gastric cancer. Additionally, MYX1715 can be utilized as a toxin in ADCs.