trek-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T78870	TWIK-1/TREK-1-IN-3		Potassium Channel
	TWIK-1/TREK-1-IN-3 is a selective and potent inhibitor of potassium channel TREK-1, inhibiting TREK-1 homodimers and TWIK-1/TREK-1 heterodimers containing two-pore-domain potassium (K2p) channels.TWIK-1/TREK-1-IN-3 exhib...		Potassium Channel
T37709	2,2,2-Trichloroethanol		Potassium Channel , Endogenous Metabolite
	2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1]. 2,2,2-trichloroethanol activates a nonclassical ...		Potassium Channel , Endogenous Metabolite
T78868	TWIK-1/TREK-1-IN-1		Potassium Channel
	Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1/TREK-1 heterodimers, both significant for its role as a...		Potassium Channel
T78869	TWIK-1/TREK-1-IN-2		Potassium Channel
	TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values of 10.13 μM and 15.5 μM, respectively. Additionally, it exh...		Potassium Channel
T0386L	Ropivacaine	LEA-103 HCl	Potassium Channel , Sodium Channel
	Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.		Potassium Channel , Sodium Channel
T0386	Ropivacaine hydrochloride	Ropivacaine monohydrochloride	Potassium Channel , Sodium Channel
	Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.		Potassium Channel , Sodium Channel
T6645	Ropivacaine hydrochloride monohydrate	Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,LEA-103 HCl	Potassium Channel , Sodium Channel
	Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.		Potassium Channel , Sodium Channel
T4224	ML335		Potassium Channel
	ML335 is a selective activator of TREK-1 and TREK-2.		Potassium Channel
T16109	ML402	ZINC3671497,N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide	Potassium Channel
	ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.		Potassium Channel
T22178L	Spadin Acetate	Spadin Acetate(1270083-24-3 Free base)	Others
	Spadin Acetate is a natural peptide derived from a propeptide released in blood. Spadin Acetate is able to block the TREK-1 channel activity. Spadin Acetate binds specifically to TREK-1 with an affinity of 10 nM.		Others
T8700	TKIM		Potassium Channel
	TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.		Potassium Channel
T14666	BL-1249		Potassium Channel
	BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2).		Potassium Channel
T67917	ML353	VU0478006	Potassium Channel
	ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 has potential as a solution to the intrinsic activity or phar...		Potassium Channel
T7774	A2793		Potassium Channel
	A2793 is a dual inhibitor of TWIK-associated acid-sensitive K+ channel 1 (TASK-1)/TRESK, with an IC50 for mTRESK of 6.8 μM. It is more selective for TRESK, and relatively weaker for TREK-1 and TALK-1.		Potassium Channel
T7775	A2764 dihydrochloride		Potassium Channel
	A2764 dihydrochloride is a highly selective inhibitor of TRESK.		Potassium Channel
T16112	ML67-33		HIV Protease
	ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels.		HIV Protease
T71955	C3001a
	C3001a is a selective activator for TREK, against other two-pore domain K+(K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a targets TREK channels in the peripheral nervous sy...
T76311	PE 22-28
	PE 22-28, a TREK-1 inhibitor exhibiting an IC50 value of 0.12 nM, is a 7 amino-acid peptide. It serves as a foundational sequence for the creation of analogs through chemical modifications and amino-acid substitution. Th...
T75944	Spadin TFA
	Spadin TFA, a natural peptide originating from a propeptide in blood, acts as a powerful TREK-1 channel inhibitor with an IC 50 of 10 nM. It boosts dorsal raphe nucleus 5-HT neurotransmission in mice, activates hippocamp...
T71852	Lig4-4
	Lig4-4 is a TREK-1 current inhibitor (IC50 = 2.06 μM) that has demonstrated potential for use as a protective agent against cerebral ischemia. It has been postulated that the neuroprotective effects of Lig4-4 against cer...