tpo — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T17146	TPO agonist 1		Others
	TPO agonist 1 is a thrombopoietin agonist. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia.		Others
T2562	Eltrombopag	SB-497115,SB-497115-GR	Thrombin
	Eltrombopag (SB-497115-GR), an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110).		Thrombin
T6825	Eltrombopag Olamine	Promacta Olamine,Revolade,Eltrombopag diethanolamine salt,SB497115,SB-497115GR	Thrombin
	Eltrombopag Olamine (Eltrombopag diethanolamine salt) is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrom...		Thrombin
T7417	Avatrombopag	YM477,AKR-501,E5501	Thrombin , Thrombopoietin Receptor
	Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.		Thrombin , Thrombopoietin Receptor
T3473	(S)-ATPO	ATPO	GluR
	(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.		GluR
T17147	TPOP146		Epigenetic Reader Domain
	TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).		Epigenetic Reader Domain
TQ0223	Lusutrombopag	S-888711,Mulpleta	Thrombin , Thrombopoietin Receptor
	Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.		Thrombin , Thrombopoietin Receptor
T3882	4”-O-Glucosylvitexin	glucosylvitexin	Thrombopoietin Receptor
	4”-O-Glucosylvitexin (glucosylvitexin) inhibits TPO activity.		Thrombopoietin Receptor
T67894	Butyzamide		Thrombopoietin Receptor , JAK
	Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mou...		Thrombopoietin Receptor , JAK
T68560	Totrombopag choline
	Totrombopag, also known LGD-4665, GSK2285921 and SB559448, is an oral thromobopoietin receptor agonist, is being developed as a new generation small molecule thrombopoietin (TPO) mimetic. It is a highly selective and po...
T40654	Avatrombopag hydrochloride	AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride
	Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC 50 of 3.3 nM. It effectively mimics the biological activities of TPO, stimulating platelet prod...
T27536	Hetrombopag olamine
	Hetrombopag olamine is a non-peptide thrombopoietin (TPO) receptor agonist with oral activity.
T62865	Rafutrombopag
	Rafutrombopag is a thrombopoietin (TPO) agonist.
T60281	MPO-IN-4
	MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC 50 of 25 nM. MPO-IN-4 also demonstrates inhibition of thyroid peroxidase (TPO) with IC50 of 2.2 μM. MPO-IN-4 has no effect on me...
T68888	Avatrombopag maleate
	Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis througho...
T38602	(E/Z)-Eltrombopag 13C4	(E/Z)-Eltrombopag 13C4,(E/Z)-SB-497115 13C4
	(E/Z)-Eltrombopag 13C4 ((E/Z)-SB-497115 13C4) is a mixture complex of E-Eltrombopag and Z-Eltrombopag, with 13C labeled. Z-Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead...
T72265	Eltrombopag methyl ester
	Eltrombopag Methyl Ester, a derivative of Eltrombopag, functions as a thrombopoietin (Tpo) receptor agonist to enhance platelet production and is employed in the study of certain thrombocytopenia variants.
T40137	MPO-IN-1
	MPO-IN-1 is a powerful and orally bioavailable indole-containing inhibitor that acts irrevocably on myeloperoxidase (MPO). With IC50 values of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively, MPO-IN-...