Neuroscience

Tedatioxetine (Lu AA24530) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with antidepressant properties.Tedatioxetine acts as a CYP2D6 substrate.

Diclofensine (Ro 8-4650) is a monoamine reuptake inhibitor that blocks dopamine (IC50=0.74 nM), norepinephrine (IC50=2.3 nM), and 5-hydroxytryptophan (IC50=3.7 nM) in synaptosomes of the rat brain. dAURK-4 hydrochloride is an inhibitor of dopamine (IC50=0.74 nM), norepinephrine (IC50=2.3 nM) and 5-hydroxytryptophan (IC50=3.7 nM).

2-(5,7-dichloro-1H-indol-3-yl)ethan-1-amine is an indoleamine compound that is structurally similar to serotonin. It is a selective agonist at the 5-HT2A receptor and has potential applications in neuroscience.

5-PT (5-Propargyltryptamide) is an alkynylated 5-HT analog that can undergo bioorthogonal click chemistry (e.g., azide-alkynyl cycloaddition reactions) used in neuroscience research as a tool compound or probe to track down proteins interacting with 5-PT and to explore the mechanism of 5-hydroxytryptamine's action in cells.

β-Galactosyl-C18-ceramide is a bioactive molecule known for its roles in modulating neuronal regulation, regulating protein kinase C (PKC) activity, and influencing hormone receptor functions. Widely applied in neuroscience research, this compound is explored for its effects on the growth and function of neuronal cells. The regulatory capabilities of β-Galactosyl-C18-ceramide offer potential applications in compound development and disease inhibition.

σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.

Dinoxyline is a potent dopamine receptor agonist, with dissociation constants (Ki values) for D1, D2, D3, and D4 receptors being 7 nM, 6 nM, 5 nM, and 43 nM, respectively. It is utilized in neuroscience research.

Jimscaline (compound R-(-)2) is a 5-HT2A agonist and a mescaline analogue, used in neuroscience research.

Lu 25-077 is a pharmacologically active N-demethylated metabolite of Lu 25-109 that can penetrate the blood-brain barrier. Lu 25-109 functions as a partial M1 agonist and an M2/M3 antagonist. Lu 25-077 is applicable in neuroscience research.

5-HT2A antagonist 3 (Formula (III)) functions as both an antagonist and an inverse agonist of the 5-HT2A receptor, exhibiting a pIC50 value of 8.7 and a pKi value of 9. It is applicable for research in neuroscience.

HPTP is a monoaminergic neurotoxin related to MPTP. It is the dehydration product of haloperidol. The agent is specifically a dopaminergic and serotonergic neurotoxin. HPTP is a prodrug of HPP+, which mediates its monoaminergic neurotoxicity, HPTP can be utilized for building neurotoxic or immuno-deficient model for research related to neuroscience.

Chloralose is an avicide and a rodenticide effective for controlling mice at temperatures below 15 °C. In addition. Chloralose is commonly used in neuroscience research and veterinary practice as an anesthetic and sedative. When used alone or together with agents such as urethane, chloralose provides long-lasting yet relatively light anesthesia.

Muscimol hydrochloride is the salt form of Muscimol, the main psychoactive component of Amanita muscaria, a potent and selective GABAA receptor agonist and partial GABAC receptor agonist, with no activity on GABAB receptors. It is commonly used in central neuroscience research, with analgesic, anxiolytic and neuroprotective effects, with the advantage of being able to cross the blood-brain barrier and can be taken orally.

Risperidone-d4 is a deuterated form of risperidone. Risperidone blocks 5-HT₂ receptors, inhibits P-glycoprotein, and antagonizes dopamine D₂ receptors (Ki 4.8 / 5.9 nM for 5-HT₂A / D₂), showing potential in research related to neuroscience.

α-Pompilidotoxin (α-PMTX), a neurotoxin sourced from Anoplius samanensis venom, reversibly and dose-dependently enhances excitatory postsynaptic currents (EPSCs), serving as a valuable tool in neuroscience research [1].

9-cis-13,14-Dihydroretinoic acid (9CDHRA) is a selective retinoid X receptor (RXR) agonist with a Kd of 90 nM. It can ameliorate memory deficits caused by impaired RXR signaling in vivo. This compound shows potential for research in the fields of neuroscience and metabolic diseases.

Cyclo(Gly-L-Pro), a cyclic dipeptide, demonstrates significant immunomodulatory activity by stimulating beneficial immune responses while simultaneously suppressing the release of the pro-inflammatory cytokine TNF-α, reducing mRNA expression of IL-1β and IL-6, and inhibiting nitric oxide (NO) production. it has also been shown to enhance memory and improve functional recovery in animal models, indicating substantial potential for neuroscience research due to its neuroprotective and immunostimulatory properties.

Homovanillic acid sulfate is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.In psychiatry and neuroscience, brain and cerebrospinal fluid levels of homovanillic acid are measured as a marker of metabolic

6-FAM-AEEAC-SHK TFA, a peptide neurotoxin derived from Stichodactyla helianthus and conjugated with a fluorescent marker, selectively blocks voltage-gated potassium channels (kv1.1 and kv1.2). By prolonging action potentials, it interferes with neural signal conduction, making it valuable in neuroscience research.

Acetylthiocholine iodide is a biochemical substrate specifically utilized for measuring cholinesterase enzyme activity. Acetylthiocholine iodide is applied in enzyme kinetics, neuroscience, and organ physiology studies to quantify cholinergic transmission efficiency and to assess neurotoxicity or pharmacological inhibition of cholinesterases.

Propionylcholine (p-toluenesulfonate) is an organic compound frequently utilized in biochemical and neuroscience research. It serves as a tool for investigating cholinergic signal transduction and esterase activity and is extensively applied in biomedical and pharmacological studies. Furthermore, this compound functions as a substrate or catalyst in certain biochemical reactions.