mlkl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T41027	MLKL-IN-2		MLK
	MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.		MLK
T79731	MLKL-IN-6		Necroptosis
	MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are crit...		Necroptosis
T73279	MLKL-IN-5
	MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .
T60885	MLKL-IN-1
	MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM.
T79831	PROTAC MLKL Degrader-1
	PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%. The compound encompasses modified cereblon (CRBN) ligands and a lenalidomide-linker as...
T7697	BIX-01294		Histone Methyltransferase , Autophagy
	BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).		Histone Methyltransferase , Autophagy
T1959	BIX-01294 trihydrochloride	BIX 01294	Histone Methyltransferase , Autophagy
	BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.		Histone Methyltransferase , Autophagy
T11520	GW806742X		MLK , VEGFR
	GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.		MLK , VEGFR
T7129	(E/Z)-Necrosulfonamide		MLK
	(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.		MLK
T6904	Necrosulfonamide	(E)-Necrosulfonamide	MLK
	(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec...		MLK
T81268	RIPK1-IN-17		RIP kinase
	RIPK1/3-IN-1 (Compound 10) is a selective inhibitor of both RIPK1 and RIPK3, effectively preventing necroptosis by blocking the phosphorylation of RIPK1, RIPK3, and MLKL [1].		RIP kinase
T78784	RIPK3-IN-3
	RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM. This compound effectively blocks RIPK3-mediated phosphorylation of MLKL, preventing its oligomerizati...
T74680	NecroIr1
	NecroIr1, an iridium(III) complex, acts as a necroptosis inducer in Cisplatin-resistant lung cancer cells (A549R). It selectively targets mitochondria, causing oxidative stress and reducing mitochondrial membrane potenti...
T74681	NecroIr2
	NecroIr2, an iridium(III) complex, functions as a necroptosis inducer in cisplatin-resistant lung cancer cells (A549R). It preferentially accumulates in mitochondria, causing oxidative stress and a reduction in mitochond...
T17010	TC13172		Others
	TC13172 is an inhibitor of mixed lineage kinase domain-like protein (EC50: 2 nM for HT-29 cells).		Others