Cyclosporin A

Cyclosporin A is a natural product and an active fungal metabolite, classified as a cyclic polypeptide immunosuppressant. It binds to cyclophilin and inhibits the activity of calcineurin (IC₅₀ = 7 nM) as well as CD11a/CD18 adhesion molecules. It is commonly used to induce uremia models.

6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]cyclosporin A is a useful organic compound for research related to life sciences and the catalog number is T64488.

Cyclosporin A-Derivative 3 is a derivative of Cyclosporin A with calcineurin inhibition [1] .

Derivative 2 is A novel Derivative of Cyclosporin A.Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin.

Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate obtained from cyclosporin A via ring-opening.

Cyclosporin A-Derivative 1, a crystalline intermediate, is derived from the opening of cyclosporin A.

Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B into hepatocytes. Cyclosporin B also

Cyclosporin E (11-Demethylcyclosporin A) is a cyclic oligopeptide isolated from imperfect fungi such as Trichoderma polysporum and is a member of the Cyclosporins family. It is valuable for investigating the structure-activity relationships and molecular dynamics of cyclosporin compounds. Cyclosporin E serves as a structural reference compound with significant research importance in medicinal chemistry and biophysics.

Cyclosporin U (SMP0V32C6L) is a cytostatic agent critical for the prevention of organ transplant rejection [1].

Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.

Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.

Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.

Acetyl-cyclosporin A aldehyde is a cyclosporin A derivative, a neurocalmodulin inhibitor and cyclophilin binder with potential anti-inflammatory, antitumor, and antiviral activity. It is used in studies of organ transplantation and autoimmune diseases.

Cyclosporin A-d4 is a deuterated form of Cyclosporin A. Cyclosporin A (Cyclosporine A) functions as an immunosuppressant by binding to cyclophilin and inhibiting calcineurin activity with an IC50 value of 7 nM. It also obstructs the adhesion molecules CD11a/CD18.

Cyclosporin Aacetate-d4 (Cyclosporine A acetate-d4; Ciclosporin A acetate-d4) is a deuterium-labeled form of Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressive agent that binds to cyclophilin, inhibiting the activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 value of 7 nM. Additionally, Cyclosporin A impedes the adhesion molecules CD11a/CD18.

Cyclosporin A-13C2,d4 (Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4) is a 13C-labeled form of Cyclosporin A. Cyclosporin A is an immunosuppressant that binds to cyclophilin, inhibiting protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 7 nM, and also suppresses the CD11a/CD18 adhesion molecules.

Cyclosporin A-d12 (Cyclosporine A-d12) is a deuterium-labeled form of Cyclosporin A. Cyclosporin A (Cyclosporine A) functions as an immunosuppressant by binding to cyclophilin and inhibiting protein phosphatase 2B (PP2B/calcineurin) with an IC50 value of 7 nM. It also inhibits the adhesion molecule CD11a/CD18.

Cyclosporin A-d4 (Major) is a deuterated compound of Cyclosporin A. Cyclosporin A has a CAS number of 59865-13-3. Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.

Cyclosporin A (Standard) is a reference standard for research and analysis in studies involving Cyclosporin A. Cyclosporin A is a natural product and an active fungal metabolite, classified as a cyclic polypeptide immunosuppressant. It binds to cyclophilin and inhibits the activity of calcineurin (IC₅₀ = 7 nM) as well as CD11a/CD18 adhesion molecules. It is commonly used to induce uremia models.

Cyclosporin A-BSA is a hapten-carrier protein conjugate formed by coupling Cyclosporin A to bovine serum albumin (BSA). As a hapten, Cyclosporin A alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Cyclosporin A-BSA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M PBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Rioprostil is a methyl prostaglandin E1 analog that decreases gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the treatment of gastric ulcers and gives significant protection against NSAID-induced gastric muco

Cyclosporin C (Cs-C) is a fungal metabolite against filamentous phytopathogenic fungi. Cyclosporin C has antifungal, antiviral, and immunosuppressant properties.