Search Result

Search Results for " bcl-2 "

Targets

BCL

169

Compounds

Natural Products

330

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T38622	Bcl-xL antagonist 2		BCL
	Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic l...		BCL
T39961	Bcl-2-IN-2
	Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL. It displays an IC50 value of 0.034 nM, suggesting its strong inhibitory activity specifically against Bcl-2. Additionally, Bcl-2-IN-2 exhi...
T10483	Lisaftoclax	Bcl-2/Bcl-xl inhibitor 1,APG-2575	BCL
	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL...		BCL
T33467	MOMIPP		PI3K
	MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts[1][2].		PI3K
T11969	MCL-1/BCL-2-IN-2		Others
	MCL-1/BCL-2-IN-2 is a potent and selective Bcl-2 and Mcl-1 dual inhibitor.		Others
T17018	TCPOBOP		BCL
	TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCPOBOP decreases Fas-induced murine liver injury by altering Bcl-2 proteins.		BCL
T12824L	S55746	BLC201	BCL
	S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).		BCL
T11970	MCL-1/BCL-2-IN-3		Others
	MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely.		Others
T11971	MCL-1/BCL-2-IN-4		Others
	MCL-1/BCL-2-IN-4 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor.		Others
T11968	MCL-1/BCL-2-IN-1		BCL
	MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].		BCL
T2099	ABT-737		Mitophagy , BCL , Autophagy
	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).		Mitophagy , BCL , Autophagy
T11944	Maritoclax	Marinopyrrole A	BCL
	Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value of 10.1 μM.		BCL
T14834	BT2		BCL
	BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 μM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 μM. Its interaction with BDK induces helix movements in the N-terminal domain, l...		BCL
T1980	HA14-1		BCL
	HA14-1, a Bcl-2/Bcl-XL antagonist, is a non-peptidic ligand of a Bcl-2 surface pocket (IC50: ~9 μM).		BCL
T6650	Sabutoclax	BI-97C1	BCL
	Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.		BCL
T14071	A-385358		BCL
	A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively.		BCL
T5346	S63845		BCL
	S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)		BCL
T14376	AZD4320		BCL
	AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the IC50s values are 26 nM, 17 nM, and 170 nM , respectively.		BCL
T14561	BI-3812		BCL
	BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 nM). BI-3812 also has antitumor activity.		BCL
T2453	BAM7		BCL
	BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM).		BCL
T6749	A-1331852		BCL
	A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.		BCL
T5408	BI-3802		BCL
	BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM. It induces polymerization of BCL6 and facilitates its degradation in a manner dependen...		BCL
T5108	ML311		BCL
	ML311 is a selective inhibitor of the Mcl-1/Bim interaction.		BCL
T6281	TW-37	TW 37	BCL
	TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM).		BCL
T2632	A-1210477		Apoptosis , BCL
	A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).		Apoptosis , BCL
T4089	FX1		Apoptosis , BCL
	FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).		Apoptosis , BCL
T6034	UMI-77	UMI77,UMI 77	BCL
	UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.		BCL
T7538	Tetraethylammonium chloride		Potassium Channel
	Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties.		Potassium Channel
T2101	Navitoclax	ABT-263	BCL
	Navitoclax (ABT-263) is a Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM) with potent and oral activity. Navitoclax has antitumor activity and induces apoptosis.		BCL
T6748	A-1155463	A 1155463,A1155463	BCL
	A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).		BCL
T3940	CID5721353	BCL6 inhibitor	Apoptosis , BCL
	CID5721353 (BCL6 inhibitor) is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove.		Apoptosis , BCL
T6778	BDA-366		BCL
	BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-ap...		BCL
T5210	BAI1		Apoptosis , BCL
	BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).		Apoptosis , BCL
T6258	Zibotentan	ZD4054	Apoptosis , Endothelin Receptor
	Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.		Apoptosis , Endothelin Receptor
T16028	IMB-XH1	Mcl1-IN-2	BCL , Antibacterial
	IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor.		BCL , Antibacterial
T82912	Bcl-2-IN-14
	Bcl-2-IN-14 (Compound 13c), a BCL-2 inhibitor, exhibits an inhibitory concentration (IC 50) of 0.471 μM, and is applicable in cancer research [1].
T79171	Bcl-2-IN-11
	Bcl-2-IN-11 (compound 6) is a potent and selective inhibitor of Bcl-2 activity, exhibiting an IC50 of 0.9 nM, and demonstrates minimal inhibition against Bcl-xl (IC50 > 1000 nM). This compound is utilized in researching ...
T74297	Bcl-2-IN-4
	Bcl-2-IN-4, an orally active and selective inhibitor of Bcl-2, demonstrates potent efficacy with an IC50 value of 1.5 nM and exhibits more than 200-fold selectivity over Bcl-xL (IC50 of 411 nM). Additionally, it effectiv...
T63676	Bcl-2-IN-6
	Bcl-2-IN-6 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2) that downregulates Bcl-2 expression and increases the expression of p53, Bax, and caspase-7 mRNA. bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast...
T5104	BTSA1		Apoptosis , BCL
	BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.		Apoptosis , BCL
T82910	Bcl-2-IN-16
	Bcl-2-IN-16 is a Bcl-2 (B-cell lymphoma 2) inhibitor [1].
T64053	Bcl-2-IN-8
	Bcl-2-IN-8 is a potent anti-cancer agent. bcl-2-IN-8 exhibits anti-proliferative effects on both drug-sensitive and drug-resistant cancer cells. bcl-2-IN-8 inhibits cell migration in a dose-dependent manner. bcl-2-IN-8 b...
T8656	CAY10404	3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T	Apoptosis , Akt , COX
	CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cel...		Apoptosis , Akt , COX
T15771	Lobaplatin	D-19466	DNA Alkylation
	Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a ...		DNA Alkylation
T5827	BI-6C9		Apoptosis , Others , Mitochondrial Metabolism
	BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.		Apoptosis , Others , Mitochondrial Metabolism
T12041	MIM1	Inhibitor of Mcl-1	BCL
	MIM1 (Inhibitor of Mcl-1) is an myeloid cell factor 1 (Mcl-1) inhibitor.		BCL
T74298	Bcl-2-IN-5
	Bcl-2-IN-5 is a potent inhibitor of BCL-2, demonstrating inhibitory concentrations (IC50) of 0.12 nM, 0.14 nM, and 0.22 nM against wild type Bcl-2, Bcl-2 D103Y, and Bcl-2 G101V, respectively. Additionally, it effectively...
T63757	Bcl-2-IN-9
	Bcl-2-IN-9 is a novel, pro-apoptotic, low cytotoxic Bcl-2 inhibitor (IC50: 2.9 μM). Bcl-2-IN-9 downregulates Bcl-2 expression, induces apoptosis in cancer cells, and exhibits high selectivity for leukemia cells.
T82914	Bcl-2-IN-12
	Bcl-2-IN-12 (Compound 1) is a potent Bcl-2 inhibitor with an IC50 value of 6 nM, utilized in cancer research [1].
T82913	Bcl-2-IN-13
	Bcl-2-IN-13 is a potent inhibitor of Bcl-2, exhibiting an IC50 of 17 nM, and holds potential for use in cancer research [1].

Compounds

Bcl-xL antagonist 2

Synonym: Bcl-2/Bcl-xl inhibitor 1,APG-2575

Target: Mitophagy, BCL, Autophagy

Maritoclax

T11944

Synonym: Marinopyrrole A

Target: Apoptosis, BCL

FX1

T4089

Synonym:

Target: Apoptosis, BCL

UMI-77

T6034

Synonym: UMI77,UMI 77

Target: BCL

Tetraethylammonium chloride

T7538

Synonym:

Target: Potassium Channel

Synonym: A 1155463,A1155463

Target: BCL

CID5721353

T3940

Synonym: BCL6 inhibitor

Target: Apoptosis, BCL

Target: Apoptosis, BCL

Zibotentan

T6258

Synonym: ZD4054

Target: Apoptosis, Endothelin Receptor

IMB-XH1

T16028

Synonym: Mcl1-IN-2

Target: BCL, Antibacterial

Target: Apoptosis, BCL

Synonym: 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

Target: Apoptosis, Akt, COX

Lobaplatin

T15771

Synonym: D-19466

Target: DNA Alkylation

BI-6C9

T5827

Synonym:

Target: Apoptosis, Others, Mitochondrial Metabolism

MIM1

T12041

Synonym: Inhibitor of Mcl-1

Cat No.	Product Name	Synonyms	Targets
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T8213	Isolinderalactone		NOS , STAT
	Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.		NOS , STAT
TN1406	Dihydrokaempferol	Aromadendrin	Apoptosis , BCL
	Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory ...		Apoptosis , BCL
TN3967	Epieriocalyxin A		ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK
	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.		ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK
T7979	2-Hydroxychalcone	2-(2-Hydroxybenzal)Acetophenone	Apoptosis , BCL , Others , NF-κB
	2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells.		Apoptosis , BCL , Others , NF-κB
T6518	Gossypol	Pogosin,BL 193,NSC 56817	BCL , Dehydrogenase
	Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.		BCL , Dehydrogenase
T6S1653	Albiflorin	Alibiflorin	Reactive Oxygen Species
	1. Albiflorin (Alibiflorin) has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoniflorin significantly ameliorated Glu-induced ...		Reactive Oxygen Species
T6S0052	Chelerythrine	Toddalin,Broussonpapyrine,Cheleritrine	Apoptosis , BCL , PKC , Autophagy
	1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiprolifera...		Apoptosis , BCL , PKC , Autophagy
T3419	Chelerythrine chloride		Apoptosis , BCL , PKC , Autophagy
	Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.		Apoptosis , BCL , PKC , Autophagy
T2S0500	Ilexsaponin A	Ilexsaponin A1	Others
	1. Ilexsaponin A (Ilexsaponin A1) shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.		Others
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T10990	Dehydrocorydaline chloride	13-Methylpalmatine chloride	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T6185	Gambogic Acid	Beta-Guttiferrin,Guttatic Acid,Guttic Acid	BCL , Autophagy
	Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 ...		BCL , Autophagy
T3322	Trans-Chalcone	Chalcone,Cinnamophenone,Chalkone	Apoptosis , Others , Antifungal , Fatty Acid Synthase
	trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.		Apoptosis , Others , Antifungal , Fatty Acid Synthase
T5679	(E)-Ferulic acid	trans-Ferulic acid,(E)-Coniferic acid	BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
	(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
T3344	Ciwujianoside B	yemuoside YM,acanthopanax senticosides B,Ciwujianoside-B	BCL , Others
	Ciwujianoside B (acanthopanax senticosides B) is the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition.		BCL , Others
T2764	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin,10-HCPT	Apoptosis , Topoisomerase
	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.		Apoptosis , Topoisomerase
T2730	Gossypol (acetic acid)	(±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid	BCL
	Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID.		BCL
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T2851	Daphnetin	7,8-Dihydroxycoumarin,Daphnetol	EGFR , PKA , PKC , Parasite , Autophagy
	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...		EGFR , PKA , PKC , Parasite , Autophagy
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T1034	Docetaxel	NSC 628503,RP-56976	Apoptosis , Microtubule Associated , Endogenous Metabolite
	Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing,...		Apoptosis , Microtubule Associated , Endogenous Metabolite
T2S0410	Euphorbia factor L1	Euphorbiasteroid	Apoptosis , P-gp
	Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, ant...		Apoptosis , P-gp
T6S1529	Cynarin	Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-,Cynarine,1,5-Dicaffeoylquinic acid	Antioxidant , Antiviral , Influenza Virus , Reactive Oxygen Species
	Cynarin (1,5-Dicaffeoylquinic acid) has neuroprotective, and antioxidant effects, it can inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
T3857	Magnolin	(+)-Magnolin	ERK
	Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.		ERK
T3867	Alpinetin	(-)-alpinetin	BCL , PPAR
	Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he...		BCL , PPAR
T7027	EURYCOMANONE	Pasakbumin A	Others
	Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p...		Others
T5S2083	Puerarin 6''-O-Xyloside		Apoptosis , Caspase
	Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 an...		Apoptosis , Caspase
T6S1418	Praeruptorin C		Antioxidant , Calcium Channel
	1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ...		Antioxidant , Calcium Channel
T2795	Amygdalin	Laetrile	Others
	Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induce...		Others
TN2103	PROCYANIDIN C1		Apoptosis
	Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.		Apoptosis
TN2254	Taccalonolide A		Apoptosis , Microtubule Associated
	Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ...		Apoptosis , Microtubule Associated
T2860	Vanillyl Alcohol	4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol	Apoptosis , Others
	Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit ...		Apoptosis , Others
T6S0653	Linarin	Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine	TNF , AChE
	1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediat...		TNF , AChE
T2823	Crocin	Gardenia Yellow,Alpha-Crocin	Others
	Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne...		Others
T3S2344	β,β-Dimethylacrylshikonin	Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK , HIF/HIF Prolyl-Hydroxylase
	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...		ERK , HIF/HIF Prolyl-Hydroxylase
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
T3864	Erianin		BCL , Antibacterial
	Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metaboli...		BCL , Antibacterial
T2966	Beta-Sitosterol	Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost	Apoptosis , Lipase , Endogenous Metabolite
	Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun...		Apoptosis , Lipase , Endogenous Metabolite
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
T6S0735	Flavokawain B	Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis , Others
	1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in...		Apoptosis , Others
T3729	Ethyl gallate	Nipagallin A,Phyllemblin,gallic acid ethyl ester	MMP , NF-κB , Akt , Antibacterial
	Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib...		MMP , NF-κB , Akt , Antibacterial
T2698	Asperosaponin VI	Akebia saponin D,Asperosaponin Ⅵ	Apoptosis , Others , Caspase
	Asperosaponin VI (Akebia saponin D) , the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures.		Apoptosis , Others , Caspase
T0186	Docetaxel trihydrate	RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate	Apoptosis , BCL , Microtubule Associated
	Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor i...		Apoptosis , BCL , Microtubule Associated
T5S0661	Koumine		Others
	1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a significant analgesic effect in rodent behavioral models of infla...		Others
T81229	Safflor yellow B
	Safflor Yellow B mitigates angiotensin II-induced injury in human umbilical vein cells by modulating Bcl-2/p22(phox) expression and demonstrates neuroprotective effects [1].
TN6419	Chamaejasmine
	Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and ind...
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Natural Products

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Synonym: Aromadendrin

Target: Apoptosis, BCL

Epieriocalyxin A

TN3967

Synonym:

Target: ERK, BCL, ROS, Caspase, DNA/RNA Synthesis, JNK

2-Hydroxychalcone

T7979

Synonym: 2-(2-Hydroxybenzal)Acetophenone

Target: Apoptosis, BCL, Others, NF-κB

Gossypol

T6518

Synonym: Pogosin,BL 193,NSC 56817

Target: BCL, Dehydrogenase

Albiflorin

T6S1653

Synonym: Alibiflorin

Target: Reactive Oxygen Species

Chelerythrine

T6S0052

Synonym: Toddalin,Broussonpapyrine,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

Chelerythrine chloride

T3419

Synonym:

Target: Apoptosis, BCL, PKC, Autophagy

Ilexsaponin A

T2S0500

Synonym: Ilexsaponin A1

Target: Others

Dehydrocorydaline

T5S2358

Synonym: Dehydrocorydalin,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline nitrate

T2S2362

Synonym:

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline chloride

T10990

Synonym: 13-Methylpalmatine chloride

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Gambogic Acid

T6185

Synonym: Beta-Guttiferrin,Guttatic Acid,Guttic Acid

Target: BCL, Autophagy

trans-Chalcone

T3322

Synonym: Chalcone,Cinnamophenone,Chalkone

Target: Apoptosis, Others, Antifungal, Fatty Acid Synthase

(E)-Ferulic acid

T5679

Synonym: trans-Ferulic acid,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

Ciwujianoside B

T3344

Synonym: yemuoside YM,acanthopanax senticosides B,Ciwujianoside-B

Target: BCL, Others

(S)-10-Hydroxycamptothecin

T2764

Synonym: 10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Gossypol (acetic acid)

T2730

Synonym: (±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid

Target: BCL

Dihydrocapsaicin

T2163

Synonym: CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Daphnetin

T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol

Target: EGFR, PKA, PKC, Parasite, Autophagy

Paris saponin VII

T4085

Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Amantadine

T7060

Synonym: 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine

Target: Others

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Docetaxel

T1034

Synonym: NSC 628503,RP-56976

Target: Apoptosis, Microtubule Associated, Endogenous Metabolite

Euphorbia factor L1

T2S0410

Synonym: Euphorbiasteroid

Target: Apoptosis, P-gp

Cynarin

T6S1529

Synonym: Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-,Cynarine,1,5-Dicaffeoylquinic acid

Target: Antioxidant, Antiviral, Influenza Virus, Reactive Oxygen Species

magnolin

T3857

Synonym: (+)-Magnolin

Target: ERK

Alpinetin

T3867

Synonym: (-)-alpinetin

Target: BCL, PPAR

EURYCOMANONE

T7027

Synonym: Pasakbumin A

Target: Others

Puerarin 6''-O-Xyloside

T5S2083

Synonym:

Target: Apoptosis, Caspase

Praeruptorin C

T6S1418

Synonym:

Target: Antioxidant, Calcium Channel

Target: Apoptosis, Microtubule Associated

Vanillyl Alcohol

T2860

Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol

Target: Apoptosis, Others

Linarin

T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine

Target: TNF, AChE

Crocin

T2823

Synonym: Gardenia Yellow,Alpha-Crocin

Target: Others

β,β-Dimethylacrylshikonin

T3S2344

Synonym: Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

Target: ERK, HIF/HIF Prolyl-Hydroxylase

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Erianin

T3864

Synonym:

Target: BCL, Antibacterial

Beta-Sitosterol

T2966

Synonym: Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost

Target: Apoptosis, Lipase, Endogenous Metabolite

Calycosin

T3923

Synonym: Cyclosin,3'-Hydroxyformononetin

Target: Apoptosis, Tyrosinase

Flavokawain B

T6S0735

Synonym: Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

Ethyl gallate

T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester

Target: MMP, NF-κB, Akt, Antibacterial

Asperosaponin VI

T2698

Synonym: Akebia saponin D,Asperosaponin Ⅵ

Target: Apoptosis, Others, Caspase

Docetaxel trihydrate

T0186

Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate

Target: Apoptosis, BCL, Microtubule Associated

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02700	BCL2 Protein, Human, Recombinant (His)	Human	E. coli
	BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a...
TMPJ-00717	BAG2 Protein, Human, Recombinant (His)	Human	E. coli
	BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is...
TMPH-03245	BCL2 Protein, Rat, Recombinant (His)	Rat	in vitro E. coli expression system
	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee...
TMPH-02520	BCL2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee...
TMPJ-00584	Bc1-w Protein, Human, Recombinant (His)	Human	E. coli
	Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing thre...
TMPY-02004	BCL-W Protein, Human, Recombinant (His)	Human	E. coli
	Beta1,4-Galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides. They have an N-terminal hydrophobic ...
TMPH-02534	BAG3 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleoti...
TMPH-02535	BAG3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleoti...
TMPY-02431	BCL-XL Protein, Human, Recombinant (His)	Human	E. coli
	B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi...
TMPY-04052	IL-17RB Protein, Human, Recombinant (His)	Human	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-06842	BMP-4 Protein, Human, Recombinant (E399D)	Human	E. coli
	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP...
TMPY-04632	IL-15 Protein, Human, Recombinant	Human	E. coli
	The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common h...
TMPJ-00038	IL-7 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 a...
TMPY-03974	Bim Protein, Human, Recombinant (His)	Human	E. coli
	BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. ...
TMPY-02564	BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)	Mouse	E. coli
	B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi...
TMPK-00636	BID Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family prot...
TMPH-00535	Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)	EBV	E. coli
	Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic pro...
TMPY-02065	BID Protein, Mouse, Recombinant (His & GST)	Mouse	E. coli
	The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro...
TMPY-04768	PRPS2 Protein, Human, Recombinant (His)	Human	E. coli
	PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via th...
TMPY-02001	RTN4 Protein, Human, Recombinant (GST)	Human	E. coli
	Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that...
TMPY-02027	BID Protein, Human, Recombinant	Human	E. coli
	The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro...
TMPJ-00455	SLAMF5 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based ...
TMPY-00431	BMP-4 Protein, Mouse, Recombinant (rFc)	Mouse	HEK293
	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP...
TMPJ-01066	CYCS Protein, Human, Recombinant (His)	Human	E. coli
	Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as...
TMPY-03850	IL-17RB Protein, Human, Recombinant (hFc)	Human	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-00352	IL-17RB Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-04706	IL-17RB Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-04162	IL-17RB Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-03471	IL-17RB Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF...
TMPY-04049	IL-15 Protein, Human, Recombinant (His)	Human	E. coli
	The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common h...
TMPJ-00681	EDIL3 Protein, Human, Recombinant (His)	Human	Human Cells
	EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at...
TMPY-04936	BCL2A1 Protein, Human, Recombinant (His)	Human	E. coli
	B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in...
TMPY-01824	Caspase-14 Protein, Human, Recombinant (His)	Human	E. coli
	Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses...
TMPY-04417	DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)	Human	Baculovirus-Insect Cells
	Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK...
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293)	Human	HEK293
	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact...
TMPY-05288	PLGF/PGF Protein, Human, Recombinant (aa 19-149)	Human	E. coli
	PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli.
TMPY-04116	KRAS Protein,Human,Recombinant(G12C & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-02011	CD96 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00871	LAYN Protein, Human, Recombinant (hFc)	Human	HEK293
	Layilin recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions bet...
TMPY-00849	ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-00850	ST2/IL-1 RL1 Protein, Human, Recombinant	Human	HEK293
	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-00891	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)	Human	HEK293
	Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is...
TMPY-00748	Nectin-2 Protein, Human, Recombinant	Human	HEK293
	Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-00005	FGF-8a Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-02358	CD98 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A tr...
TMPY-01691	Clusterin Protein, Human, Recombinant (CLU34, His)	Human	HEK293
	Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-00341	FGFR3 Protein, Human, Recombinant (alpha IIIb, His)	Human	HEK293
	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ ...
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His)	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted i...
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)	Mouse	Human Cells
	ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
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BCL2 Protein, Human, Recombinant (His)

TMPY-02700

Species: Human

Expression System: E. coli

BAG2 Protein, Human, Recombinant (His)

TMPJ-00717

Species: Human

Expression System: E. coli

BCL2 Protein, Rat, Recombinant (His)

TMPH-03245

Species: Rat

Expression System: in vitro E. coli expression system

BCL2 Protein, Mouse, Recombinant (His)

TMPH-02520

Species: Mouse

Expression System: E. coli

Bc1-w Protein, Human, Recombinant (His)

TMPJ-00584

Species: Human

Expression System: E. coli

BCL-W Protein, Human, Recombinant (His)

TMPY-02004

Species: Human

Expression System: E. coli

BAG3 Protein, Mouse, Recombinant (His)

TMPH-02534

Species: Mouse

Expression System: Yeast

BAG3 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02535

Species: Mouse

Expression System: E. coli

BCL-XL Protein, Human, Recombinant (His)

TMPY-02431

Species: Human

Expression System: E. coli

IL-17RB Protein, Human, Recombinant (His)

TMPY-04052

Species: Human

Expression System: HEK293

BMP-4 Protein, Human, Recombinant (E399D)

TMPY-06842

Species: Human

Expression System: E. coli

IL-15 Protein, Human, Recombinant

TMPY-04632

Species: Human

Expression System: E. coli

IL-7 Protein, Mouse, Recombinant (His)

TMPJ-00038

Species: Mouse

Expression System: Human Cells

Bim Protein, Human, Recombinant (His)

TMPY-03974

Species: Human

Expression System: E. coli

BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)

TMPY-02564

Species: Mouse

Expression System: E. coli

BID Protein, Mouse, Recombinant (His)

TMPK-00636

Species: Mouse

Expression System: E. coli

Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)

TMPH-00535

Species: EBV

Expression System: E. coli

BID Protein, Mouse, Recombinant (His & GST)

TMPY-02065

Species: Mouse

Expression System: E. coli

PRPS2 Protein, Human, Recombinant (His)

TMPY-04768

Species: Human

Expression System: E. coli

RTN4 Protein, Human, Recombinant (GST)

TMPY-02001

Species: Human

Expression System: E. coli

BID Protein, Human, Recombinant

TMPY-02027

Species: Human

Expression System: E. coli

SLAMF5 Protein, Mouse, Recombinant (His)

TMPJ-00455

Species: Mouse

Expression System: Human Cells

BMP-4 Protein, Mouse, Recombinant (rFc)

TMPY-00431

Species: Mouse

Expression System: HEK293

CYCS Protein, Human, Recombinant (His)

TMPJ-01066

Species: Human

Expression System: E. coli

IL-17RB Protein, Human, Recombinant (hFc)

TMPY-03850

Species: Human

Expression System: HEK293

IL-17RB Protein, Rhesus, Recombinant (His)

TMPY-00352

Species: Rhesus

Expression System: HEK293

IL-17RB Protein, Rhesus, Recombinant (hFc)

TMPY-04706

Species: Rhesus

Expression System: HEK293

IL-17RB Protein, Mouse, Recombinant (hFc)

TMPY-04162

Species: Mouse

Expression System: HEK293

IL-17RB Protein, Mouse, Recombinant (His)

TMPY-03471

Species: Mouse

Expression System: HEK293

IL-15 Protein, Human, Recombinant (His)

TMPY-04049

Species: Human

Expression System: E. coli

EDIL3 Protein, Human, Recombinant (His)

TMPJ-00681

Species: Human

Expression System: Human Cells

BCL2A1 Protein, Human, Recombinant (His)

TMPY-04936

Species: Human

Expression System: E. coli

Caspase-14 Protein, Human, Recombinant (His)

TMPY-01824

Species: Human

Expression System: E. coli

DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)

TMPY-04417

Species: Human

Expression System: Baculovirus-Insect Cells

GDNF Protein, Human, Recombinant (HEK293)

TMPY-02792

Species: Human

Expression System: HEK293

PLGF/PGF Protein, Human, Recombinant (aa 19-149)

TMPY-05288

Species: Human

Expression System: E. coli

KRAS Protein,Human,Recombinant(G12C & Q61H, His)

TMPY-04116

Species: Human

Expression System: E. coli

CD96 Protein, Human, Recombinant (His)

TMPY-02011

Species: Human

Expression System: HEK293

LAYN Protein, Human, Recombinant (hFc)

TMPY-00871

Species: Human

Expression System: HEK293

ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)

TMPY-00849

Species: Human

Expression System: HEK293

ST2/IL-1 RL1 Protein, Human, Recombinant

TMPY-00850

Species: Human

Expression System: HEK293

Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)

TMPY-00891

Species: Human

Expression System: HEK293

Nectin-2 Protein, Human, Recombinant

TMPY-00748

Species: Human

Expression System: HEK293

FGF-8a Protein, Human, Recombinant

TMPY-00005

Species: Human

Expression System: E. coli

CD98 Protein, Mouse, Recombinant (His)

TMPY-02358

Species: Mouse

Expression System: HEK293

Clusterin Protein, Human, Recombinant (CLU34, His)

TMPY-01691

Species: Human

Expression System: HEK293

FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

TMPY-00341

Species: Human

Expression System: HEK293

EIF5A2 Protein, Human, Recombinant (His)

TMPY-03795

Species: Human

Expression System: E. coli

ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)

TMPJ-00850

Species: Mouse

Expression System: Human Cells

C-ABL/ABL1 Protein, Human, Recombinant (GST)

TMPY-04396

Species: Human

Expression System: Baculovirus-Insect Cells

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Cat No.	Product Name
L9000	Apoptosis Compound Library		1760 compounds
	A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;

Libraries

Apoptosis Compound Library

L9000

Compounds: 1760