BIX

BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).

BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.

BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.

BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP) GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.

BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).

Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation.

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.

BIX02189 is a potent and selective inhibitor of MEK5 and ERK5 (IC50: 1.5 nM and 59 nM).

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases. BIX01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro.

BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1 2, JNK2, and ERK2.

Bixin is isolated from the seeds of Bixa orellana and possesses anti-tumor, anti-inflammatory, and antioxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation, and ROS generation.

BIX02188 is a selective and potent MEK5 inhibitor that inhibits MEK5-induced apoptosis in cells expressing the oncogenic mutant FLT3-ITD.

Acetobixan is a cellulose synthesis inhibitor.

Bixafen is a succinate dehydrogenase inhibitor with hepatotoxicity, pancreotoxicity, and fungicidal activity, used to control crop diseases.

Elobixibat hydrate, a potent inhibitor of the ileal bile acid transporter (IBAT), exhibits IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human, mouse, and canine IBAT, respectively. It is utilized in the research of chronic idiopathic constipation (CIC).

Norbixin, a carotenoid found in B. orellana, exhibits various biological activities including binding to the peroxisome proliferator-activated receptor γ (PPARγ) with a Ki of 1.15 µM in a cell-free assay. At a dosage of 47.7 mg/kg, norbixin effectively alleviates hyperglycemia, hyperinsulinemia, and insulin resistance, in addition to reducing serum lipid levels, cardiac thiobarbituric acid reactive substances (TBARS), and glutathione (GSH) in rat cardio-metabolic syndrome models. It also lowers serum levels of oxidized LDL, aortic protein oxidation, and the atherosclerotic area in a rabbit cholesterol-induced atherosclerosis model. Furthermore, norbixin, administered at 0.1 and 1 mg/kg per day, minimizes mercury-induced DNA damage in rat hepatocytes and leukocytes and prevents photoreceptor degeneration in an Abca4-/- Rdh8-/- mouse model of age-related macular degeneration (AMD).

(S)-Elobixibat is the S-isomer of Elobixibat. It is an orally active inhibitor of Apical Sodium-Dependent Bile (IBAT) and can reduce LDL cholesterol, increase serum GLP-1, and promote colonic motility. This compound shows potential for treating metabolic syndrome and can be studied for constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors.

Elobixibat-d5 is a deuterated compound of Elobixibat. Elobixibat has a CAS number of 439087-18-0. Elobixibat is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation.

Norbixin is a carotenoid used as a natural orange-red food coloring agent, and it possesses anti-atherosclerotic properties.

Norbixin disodium is a carotenoid used as a natural orange red food coloring agent, and it possesses anti-atherosclerotic properties.

α-Norbixin is a natural product that can be used in related research in the field of life sciences. Its product number is TN8731.

BIX HCl is a sodium-hydrogen exchange type 1 inhibitor.

CSV0C018875 is a quinoline-based EHMT2 G9a inhibitor that exhibits lower cytotoxicity compared to BIX-01294 [1].

CSV0C018875 Hydrochloride is a novel G9a (EHMT2) inhibitor, binding tightly inside the active site cavity of G9a, inhibiting the activity of G9a in both enzyme and cell based assays with much lesser toxicity than BIX-0129.