bix — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1959	BIX-01294 trihydrochloride	BIX 01294	Histone Methyltransferase , Autophagy
	BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.		Histone Methyltransferase , Autophagy
T5428	BIX 02565		LRRK2 , S6 Kinase
	BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).		LRRK2 , S6 Kinase
T7697	BIX-01294		Histone Methyltransferase , Autophagy
	BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).		Histone Methyltransferase , Autophagy
T21295	BIX02189	BIX 02189	ERK , MEK
	BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).		ERK , MEK
T30480	BiP inducer X	BIX	Apoptosis
	BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.		Apoptosis
T10553	BIX-01338 hydrate		Others
	BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.		Others
T6324	(E/Z)-BIX02188	334949-59-6	ERK , MEK , TGF-beta/Smad
	BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, JNK2, and ERK2.		ERK , MEK , TGF-beta/Smad
T2416	BIX02189		ERK , MEK , TGF-beta/Smad
	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.		ERK , MEK , TGF-beta/Smad
T23800	BI-9627 hydrochloride	BIX Hydrochloride,BIX HCl
	BIX HCl is a sodium-hydrogen exchange type 1 inhibitor.
T35567	BIX01294 (hydrochloride hydrate)
	The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3)...
T1744	BIX02188		Apoptosis , MEK
	BIX02188 is a selective and potent MEK5 inhibitor that inhibits MEK5-induced apoptosis in cells expressing the oncogenic mutant FLT3-ITD.		Apoptosis , MEK
T15209	Elobixibat	AZD 7806,A 3309	Others
	Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation.		Others
T83915	Norbixin hydrate
	Norbixin, a carotenoid found in B. orellana, exhibits various biological activities including binding to the peroxisome proliferator-activated receptor γ (PPARγ) with a Ki of 1.15 µM in a cell-free assay. At a dosage of ...
T23612	Acetobixan
	Acetobixan is a cellulose synthesis inhibitor.
T10554	Bixin		Others
	Bixin is isolated from the seeds of Bixa orellana and possesses anti-tumor, anti-inflammatory, and antioxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation, and RO...		Others
T66540	Bixafen
	Bixafen is a useful organic compound for research related to life sciences. The catalog number is T66540 and the CAS number is 581809-46-3.
T72515	Elobixibat hydrate	A 3309 hydrate ; AZD 7806 hydrate,AZD 7806 hydrate,A 3309 hydrate
	Elobixibat hydrate, a potent inhibitor of the ileal bile acid transporter (IBAT), exhibits IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human, mouse, and canine IBAT, respectively. It is utilized i...
T71824	CSV0C018875 Hydrochloride
	CSV0C018875 Hydrochloride is a novel G9a (EHMT2) inhibitor, binding tightly inside the active site cavity of G9a, inhibiting the activity of G9a in both enzyme and cell based assays with much lesser toxicity than BIX-012...
T60786	CSV0C018875
	CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].