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Results for "

BGC-823

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    22
    TargetMol | Inhibitors_Agonists
  • Natural Products
    12
    TargetMol | Natural_Products
  • Disease Modeling
    1
    TargetMol | Disease_Modeling_Products
Vadimezan
NSC 640488, DMXAA, ASA-404, 5,6-Dimethylxanthenone-4-acetic Acid
T6273117570-53-3
Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.
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Capsaicin
Zostrix, Qutenza, 8-Methyl-N-vanillyl-trans-6-nonenamide, (E)-Capsaicin
T1062404-86-4
Capsaicin ((E)-Capsaicin) is a natural product extracted from Capsicum annuum, and is a TRPV1 agonist (EC50=0.29 μM). Capsaicin has antitumor, anti-inflammatory, antioxidant and neuroprotective activities.
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Methotrexate
WR19039, NCI-C04671, CL14377, Amethopterin
T148559-05-2
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
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Ursolic acid
Urson, Prunol, NSC-4060, NSC 167406, Malol
T072277-52-1
Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.
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sodium dichloroacetate
Sodium Dichloroacetate, Sodium dichloroacetate (DCA), Sodium bichloroacetic acid, DCA sodium salt
T36042156-56-1
Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.
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Sertindole
Lu 23-174
T5858106516-24-9
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C, with Kds of 2.7, 20, 0.14, and 6 nM, respectively.
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Tanespimycin
NSC 330507, KOS 953, CP 127374, 17-AAG
T629075747-14-7
Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
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Apoptosis inducer 25
T2002682763063-15-4
Apoptosisinducer 25 (Compound 4H) demonstrates potent anticancer capabilities by inhibiting the proliferation of BGC-823 cancer cells with an IC50 of 0.37 μM. It induces apoptosis in BGC-823 cells, causes mitochondrial dysfunction, and arrests the cell cycle at the G2 M phase. Additionally, Apoptosisinducer 25 exhibits favorable pharmacokinetic properties in rats.
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10-14 weeks
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Apoptosis inducer 24
T2000712763063-09-6
Apoptosisinducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with an IC50 range of 1.2-4.8 μM. It arrests the cell cycle at the G2 M phase, induces apoptosis in BGC-823 cells, and causes mitochondrial dysfunction. In mice, Apoptosisinducer 24 exhibits antitumor activity without significant toxicity, having an LD50 of 91.2 mg kg.
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Diallyl Tetrasulfide
ICD-1585
T360572444-49-7
Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg/L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg/L, respectively).[1] It reduces cadmium-induced increases in hepatic levels of thiobarbituric acid reactive substances (TBARS) and increases cadmium-induced decreases in the hepatic activity of superoxide dismutase (SOD1), catalase, GST, and glucose-6-phosphate dehydrogenase (G6PDH) in rats when administered at a dose of 40 mg/kg.[2] Diallyl tetrasulfide is cytotoxic to MCF-7 breast cancer cells (IC50 = 92 μM) and reduces tumor growth in a BGC-823 mouse xenograft model when administered at doses of 20, 30, and 40 mg/kg for 32 days.[3],[4]
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TRPM7-IN-1
T2014131909225-07-5
TRPM7-IN-1 (compound SUD) is a benzamide-urea derivative and an effective inhibitor of TRPM7. This compound induces cell cycle arrest and apoptosis in MCF-7 and BGC-823 cells, reducing their migration capabilities. It decreases vimentin expression while increasing E-cadherin expression. TRPM7-IN-1 reduces TRPM7-like currents and inhibits TRPM7 expression by activating the PI3K Akt signaling pathway. This compound shows potential as a therapeutic agent for reducing breast and gastric cancer metastasis by targeting TRPM7 expression and activity.
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10-14 weeks
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Angeloylbinankadsurin A
T8311777165-80-1
Angeloylbinankadsurin A (compound 7), an anti-rheumatoid arthritis (RA) agent, can be extracted from the EtOAc and CH2Cl2 extracts of Black Tiger Beard. It displays inhibitory effects on RA-FLS cells with an IC50 of 11.70 μM and exhibits mild toxicity to human cancer cell lines Hela and BGC-823, with IC50 values of 19.9 μM and 21.93 μM, respectively [1].
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Eupalinolide B
T6S2238877822-41-8
Eupalinolide A has the effects of relieving phlegm and relieving cough, clearing away heat and detoxification, diuretic swelling and reducing blood pressure.
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Schisanlactone E
TN2184136040-43-2
Schisanlactone E may show moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60.
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Aphagranin A
TN34291318173-53-3
Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.
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Pterisolic acid A
TN48431401419-85-9
Pterisolic acid A shows moderate activity against HCT-116,Hep G2 and BGC-823 cell lines.
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LSD1-IN-27
T776352904571-94-2
LSD1-IN-27 is a potent LSD1 inhibitor with an IC50 value of 13 nM.LSD1-IN-27 inhibited the stemness and migration of gastric cancer cells.LSD1-IN-27 inhibited the expression of PD-L1 in BGC-823 and MFC cells.LSD1-IN-27 potentiated the T-cell immune response against gastric cancer.
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Cyclocommunol
TN3740145643-96-5
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation.
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11alpha,12alpha-Oxidotaraxerol palmitate
TN2590495389-95-2
11alpha,12alpha-Oxidotaraxerol palmitate shows selective cytotoxicity against HCT-8, Bel-7402, BGC-823, A549 and A2780.
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4'-Demethylpodophyllotoxone
T8332093780-84-8
4'-Demethylpodophyllotoxone, an intermediate in the biotransformation pathway of Alternaria alternata S-f6, undergoes further modification with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP). This modification yields a novel compound that exhibits potent inhibitory effects on the human gastric cancer cell line BGC-823 [1].
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TrxR1-IN-1
T78781
Compound 5j, also known as TrxR1-IN-1, is a TrxR1 inhibitor with an IC50 of 8.8 μM. It exhibits anticancer activity, demonstrating IC50 values of 1.5 μM in MCF-7, 1.7 μM in HeLa, 2.4 μM in BGC-823, 2.8 μM in SW-480, and 2.1 μM in A549 cells. Additionally, TrxR1-IN-1 possesses antioxidant activity, effectively scavenging the DPPH radical [1].
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Eupalinolide A
T5826877822-40-7
Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.
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