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Antagonist G TFA

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Antagonist G TFA
T75834
Antagonist G TFA is a potent antagonist of vasopressin and exhibits weaker antagonistic effects on GRP and Bradykinin. Additionally, this compound promotes AP-1 transcription and enhances cellular sensitivity to chemotherapy [1] [2].
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Ac-RYYRIK-NH2 TFA
T75907
Ac-RYYRIK-NH2 TFA acts as both a potent partial agonist for ORL1 when transfected in CHO cells (K d = 1.5 nM) and an endogenous ligand of ORL1. Moreover, it serves as a specific antagonist that inhibits G protein activation and competitively blocks the stimulation of [35S]-GTPγS binding to G proteins by nociceptin orphanin FQ (noc OFQ) in rat brain membranes and sections [1].
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