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Ebenaceae, the persimmon or ebony family, includes trees and shrubs placed in four genera, with about 855 species found throughout the tropics and some also in temperate regions. Diospyros mesipiliformis (Ebenaceae) is a tropical and subtropical tree that has several ethnopharmacological applications in Sudanese folk medicine. Different parts of the plants are used to remedy a number of ailments including malaria, pneumonia, syphilis, dermatomycoses, diarrhea, skin infections, toothache, and headache. The extract of the stem bark of Diospyros mespiliformis afforded lupeol, betulinic acid, betulin, and lupeone.