Src

Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. Frk has homologs in invertebrates such as flies and worms, and Src homologs exist in organisms as diverse as unicellular choanoflagellates, but the SrcA and SrcB subfamilies are specific to vertebrates. Src family kinases contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail.

Cat. No.	Product name	CAS No.	Purity
T11916	Lyn-IN-1	887650-05-7	98%
T11916	Lyn-IN-1 is a selective and potent dual inhibitor of Bcr-Abl and Lyn
T2608	CHIR-98014	252935-94-7	98%
T2608	CHIR-98014 is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
T15675	Tirbanibulin Mesylate	1080645-95-9	98%
T15675	Tirbanibulin Mesylate is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
T1812	KX1-004	518058-84-9	98%
T1812	KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.
TQ0132	A 419259 trihydrochloride	1435934-25-0	98%
TQ0132	A 419259 trihydrochloride is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).
T4597	UM-164	903564-48-7	98%
T4597	UM-164 is a highly potent inhibitor of c-Src with a Kd of 2.7 nM. UM-164 also potently inhibits p38α and p38β.
T9002	SquarunkinA	2101958-02-3	98%
T9002	squarunkinA is a novel modulator of the UNC119-Cargo Interaction, potently and selectively inhibiting the binding of a myristoylated peptide representing the N-t...
T6227	Benidipine hydrochloride	91599-74-5	98%
T6227	Benidipine HCl, a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.
T1985	WHI-P154	211555-04-3	98%
T1985	WHI-P154 is a potent JAK3 inhibitor.
T22306	DGY-06-116	T22306	98%
T22306	DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.
T9017	HPK1-IN-2 dihydrochloride	2056122-11-1	98%
T9017	HPK1-IN-2 dihydrochloride is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1;IC50<0.05 μΜ). It also inhibits Lck (0.05 μΜ
T6078	Saracatinib	379231-04-6	98%
T6078	Saracatinib (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.
T6730	WAY-600	1062159-35-6	98%
T6730	WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); sel...
T2372	Ponatinib	943319-70-8	98%
T2372	Ponatinib is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively).
T2382	Vemurafenib	918504-65-1	98%
T2382	Vemurafenib (PLX4032) is a novel and potent B-Raf (V600E) inhibitor (IC50: 31 nM).
T4133	CCT196969	1163719-56-9	98%
T4133	CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.
T2415	PP121	1092788-83-4	98%
T2415	PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , ...
T6345	Tirbanibulin	897016-82-9	98%
T6345	KX2-391 is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cance...
T6311	Bafetinib	859212-16-1	98%
T6311	Bafetinib (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and ...
T3319	Scutellarein	529-53-3	98%
T3319	Scutellarein reduces inflammatory responses by inhibiting Src kinase activity.