T11916 |
Lyn-IN-1
|
887650-05-7
|
98%
|
|
Lyn-IN-1 is a selective and potent dual inhibitor of Bcr-Abl and Lyn
|
T2608 |
CHIR-98014
|
252935-94-7
|
98%
|
|
CHIR-98014 is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
|
T15675 |
Tirbanibulin Mesylate
|
1080645-95-9
|
98%
|
|
Tirbanibulin Mesylate is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
|
T1812 |
KX1-004
|
518058-84-9
|
98%
|
|
KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.
|
TQ0132 |
A 419259 trihydrochloride
|
1435934-25-0
|
98%
|
|
A 419259 trihydrochloride is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).
|
T4597 |
UM-164
|
903564-48-7
|
98%
|
|
UM-164 is a highly potent inhibitor of c-Src with a Kd of 2.7 nM. UM-164 also potently inhibits p38α and p38β.
|
T9002 |
SquarunkinA
|
2101958-02-3
|
98%
|
|
squarunkinA is a novel modulator of the UNC119-Cargo Interaction, potently and selectively inhibiting the binding of a myristoylated peptide representing the N-t...
|
T6227 |
Benidipine hydrochloride
|
91599-74-5
|
98%
|
|
Benidipine HCl, a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.
|
T1985 |
WHI-P154
|
211555-04-3
|
98%
|
|
WHI-P154 is a potent JAK3 inhibitor.
|
T22306 |
DGY-06-116
|
T22306
|
98%
|
|
DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.
|
T9017 |
HPK1-IN-2 dihydrochloride
|
2056122-11-1
|
98%
|
|
HPK1-IN-2 dihydrochloride is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1;IC50<0.05 μΜ). It also inhibits Lck (0.05 μΜ
|
T6078 |
Saracatinib
|
379231-04-6
|
98%
|
|
Saracatinib (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.
|
T6730 |
WAY-600
|
1062159-35-6
|
98%
|
|
WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); sel...
|
T2372 |
Ponatinib
|
943319-70-8
|
98%
|
|
Ponatinib is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively).
|
T2382 |
Vemurafenib
|
918504-65-1
|
98%
|
|
Vemurafenib (PLX4032) is a novel and potent B-Raf (V600E) inhibitor (IC50: 31 nM).
|
T4133 |
CCT196969
|
1163719-56-9
|
98%
|
|
CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.
|
T2415 |
PP121
|
1092788-83-4
|
98%
|
|
PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , ...
|
T6345 |
Tirbanibulin
|
897016-82-9
|
98%
|
|
KX2-391 is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cance...
|
T6311 |
Bafetinib
|
859212-16-1
|
98%
|
|
Bafetinib (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and ...
|
T3319 |
Scutellarein
|
529-53-3
|
98%
|
|
Scutellarein reduces inflammatory responses by inhibiting Src kinase activity.
|