NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
TN3537	Braylin	6054-10-0	98%
TN3537	Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
TN3539	Broussonin A	73731-87-0	98%
TN3539	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN1104	Cyanidin 3-sambubioside chloride	33012-73-6	98%
TN1104	Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active s...
TN3839	Desoxo-narchinol A	53859-06-6	98%
TN3839	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TMA1890	Icariside F2	115009-57-9	98%
TMA1890	Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-ÎºB inhibitory effects, wit...
TN1598	Dunnianol	139726-29-7	98%
TN1598	Dunnianol shows anti-inflammatory activity and moderate antibacterial activity.
T12828	Salicortin	1887055-63-1	98%
T12828	Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity...
TN1484	Cheilanthifoline	483-44-3	98%
TN1484	Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation o...
TN2775	2-Methoxystypandrone	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TN3144	6,4'-Dihydroxy-7-methoxyflavanone	189689-32-5	98%
TN3144	6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, an...
TN4604	Myricanone	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN3620	Celaphanol A	244204-40-8	98%
TN3620	Celaphanol A shows moderate inhibition in both NF-ÎºB activation and nitric oxide production, suggests that it is a possible inhibitor of the NF-kappaB pathway a...
TN2075	Pimaric acid	127-27-5	98%
TN2075	Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human ...
TN4420	Latifolin	10154-42-4	98%
TN4420	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
TN4490	Manassantin B	88497-88-5	98%
TN4490	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV ...
TN3922	Effusanin E	76470-15-0	98%
TN3922	Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
TN4213	Hirsutenone	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN5019	Siegeskaurolic acid	52645-97-3	98%
TN5019	Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN4194	Heliangin	13323-48-3	98%
TN4194	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 cells...
TN1834	Kobusin	36150-23-9	98%
TN1834	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...