NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T2921	Sinomenine hydrochloride	6080-33-7	98%
T2921	Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
TN2232	Soyasaponin Ab	118194-13-1	98%
TN2232	Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
T3772	Maslinic acid	4373-41-5	98%
T3772	Maslinic acid is a DNA polymerase B inhibitor.
TN1786	Isomerazin	1088-17-1	98%
TN1786	Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
T5S1607	Morusin	62596-29-6	98%
T5S1607	1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apopto...
TN6730	Epoxyazadiradione	18385-59-6	98%
TN6730	Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cell...
TN6726	Methyl chlorogenate	29708-87-0	98%
TN6726	Methyl chlorogenate is isolated from Eriobotrya japonica which is the inhibitor of NFkappaB.
T7030	Anemarsaponin B	139051-27-7	98%
T7030	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
T3877	Esculentoside A	65497-07-6	98%
T3877	Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. E...
TN3609	Catalposide	6736-85-2	98%
TN3609	Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
T1144	Lidocaine hydrochloride	73-78-9	98%
T1144	Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged...
T3416	Aucubin	479-98-1	98%
T3416	Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
T5S1632	Barlerin	57420-46-9	98%
T5S1632	8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
T2817	Picroside II	39012-20-9	98%
T2817	Picroside II is the main active ingredient in iridoid glycosides. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological ...
T2179	Triptolide	38748-32-2	98%
T2179	Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
T1301	Guaiacol	90-05-1	98%
T1301	Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesth...
T3603	Sodium lauryl sulfoacetate	1847-58-1	98%
T3603	Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
T2745	18α-Glycyrrhetinic acid	1449-05-4	98%
T2745	Enoxolone (INN, BAN; also known as glycyrrhetinic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrh...
T5687	WITHAFERIN A	5119-48-2	98%
T5687	WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or...
TN1116	Schisandrone	98619-25-1	98%
TN1116	Schisandrone is a 4-aryltetrahydrofuran lignan extracted from the dried fruit of Schisandra chinensis.