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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Cat. No. Product name CAS No. Purity Chemical Structure
T2921 Sinomenine hydrochloride 6080-33-7 98%
Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
TN2232 Soyasaponin Ab 118194-13-1 98%
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
T3772 Maslinic acid 4373-41-5 98%
Maslinic acid is a DNA polymerase B inhibitor.
TN1786 Isomerazin 1088-17-1 98%
Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
T5S1607 Morusin 62596-29-6 98%
1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apopto...
TN6730 Epoxyazadiradione 18385-59-6 98%
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cell...
TN6726 Methyl chlorogenate 29708-87-0 98%
Methyl chlorogenate is isolated from Eriobotrya japonica which is the inhibitor of NFkappaB.
T7030 Anemarsaponin B 139051-27-7 98%
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
T3877 Esculentoside A 65497-07-6 98%
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. E...
TN3609 Catalposide 6736-85-2 98%
Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
T1144 Lidocaine hydrochloride 73-78-9 98%
Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged...
T3416 Aucubin 479-98-1 98%
Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
T5S1632 Barlerin 57420-46-9 98%
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
T2817 Picroside II 39012-20-9 98%
Picroside II is the main active ingredient in iridoid glycosides. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological ...
T2179 Triptolide 38748-32-2 98%
Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
T1301 Guaiacol 90-05-1 98%
Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesth...
T3603 Sodium lauryl sulfoacetate 1847-58-1 98%
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
T2745 18α-Glycyrrhetinic acid 1449-05-4 98%
Enoxolone (INN, BAN; also known as glycyrrhetinic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrh...
T5687 WITHAFERIN A 5119-48-2 98%
WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or...
TN1116 Schisandrone 98619-25-1 98%
Schisandrone is a 4-aryltetrahydrofuran lignan extracted from the dried fruit of Schisandra chinensis.
Sinomenine hydrochloride
T2921
Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
Soyasaponin Ab
TN2232
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
Maslinic acid
T3772
Maslinic acid is a DNA polymerase B inhibitor.
Isomerazin
TN1786
Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
Morusin
T5S1607
1. Morusin possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apopto...
Epoxyazadiradione
TN6730
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cell...
methyl chlorogenate
TN6726
Methyl chlorogenate is isolated from Eriobotrya japonica which is the inhibitor of NFkappaB.
anemarsaponin B
T7030
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
Esculentoside A
T3877
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. E...
Catalposide
TN3609
Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
Lidocaine hydrochloride
T1144
Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged...
Aucubin
T3416
Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
Barlerin
T5S1632
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
Picroside II
T2817
Picroside II is the main active ingredient in iridoid glycosides. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological ...
Triptolide
T2179
Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
Guaiacol
T1301
Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesth...
Sodium lauryl sulfoacetate
T3603
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
18α-Glycyrrhetinic acid
T2745
Enoxolone (INN, BAN; also known as glycyrrhetinic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrh...
WITHAFERIN A
T5687
WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or...
Schisandrone
TN1116
Schisandrone is a 4-aryltetrahydrofuran lignan extracted from the dried fruit of Schisandra chinensis.
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