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MELK

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.

  • HTH-01-091
    T241522000209-42-5In house
    HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be used to study breast cancer.
    • $296
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  • MELK-IN-1
    T119972095596-44-2In house
    MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
    • $51
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    TargetMol | Inhibitor Sale
  • OTSSP167
    T17591431697-89-0
    OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
    • $34
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    TargetMol | Citations Cited
  • MELK-8a Dihydrochloride
    T35342
    MELK-8a Dihydrochloride is a useful organic compound for research related to life sciences and the catalog number is T35342.
    • $502
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    TargetMol | Inhibitor Sale
  • NMS-P715
    T122371202055-32-0
    NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
    • $72
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    TargetMol | Inhibitor Sale
  • Antitumor agent-116
    T79582
    Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis. It demonstrates binding affinity for the MELK receptor [1].
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  • MELK-8a hydrochloride
    T119962096992-20-8
    MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM). 
    • $35
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  • JTV-519 hemifumarate
    T117321435938-25-2
    JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.
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  • OTSSP167 hydrochloride
    T215591431698-10-0
    OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
    • $34
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