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PI3K/Akt/mTOR signaling MELK

MELK

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.
Cat No. product name
T21559 OTSSP167 hydrochloride OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
T11997 MELK-IN-1 MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
T11996 MELK-8a hydrochloride MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor.(IC50:2 nM).
T11732 JTV-519 hemifumarate JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a p...
T1759 OTSSP167 MELK Inhibitor OTS167 is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
OTSSP167 hydrochloride
T21559CAS 1431698-10-0
OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
MELK-IN-1
T11997CAS 2095596-44-2
MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
MELK-8a hydrochloride
T11996CAS 2096992-20-8
MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor.(IC50:2 nM).
JTV-519 hemifumarate
T11732CAS 1435938-25-2
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a p...
OTSSP167
T1759CAS 1431697-89-0
MELK Inhibitor OTS167 is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.