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Integrase

Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates—forms covalent links between—its DNA (genetic information) into that of the host cell it infects.[citation needed] Retroviral INs are not to be confused with phage integrases (recombinases), such as λ phage integrase, as discussed in site-specific recombination.

  • MK-2048
    T6589869901-69-9In house
    MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
    • $621
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  • Raltegravir
    T2239L518048-05-0
    Raltegravir (MK-0518) is a pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIV INFECTION.
    • $38
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    TargetMol | Citations Cited
  • Lucialdehyde B
    TN4455480439-84-7
    Lucialdehyde B exhibits potent inhibitory activity against herpes simplex virus. It shows cytotoxic effects on Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines.
    • $345
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  • Ganoderone A
    TN1671873061-79-1
    Ganoderone A exhibits potent inhibitory activity against herpes simplex virus.
    • $820
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  • Raltegravir potassium
    T2239871038-72-1
    Raltegravir potassium (MK 0518 potassium salt) salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
    • $34
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