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FXR

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4379 Tropifexor 1383816-29-2 99.3%
Tropifexor
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
T8895 Altenusin 31186-12-6 98.97%
Altenusin
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
T29078 Ursodeoxycholic acid sodium 2898-95-5 98.55%
Ursodeoxycholic acid sodium
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeox...
T27460 GSK2324 1020567-30-9 98.50%
GSK2324
GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.
T5574 Guggulsterone 95975-55-6 98%
Guggulsterone
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T7436 Cilofexor 1418274-28-8 98%
Cilofexor
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
T2968 Hyodeoxycholic acid 83-49-8 97.26%
Hyodeoxycholic acid
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
T8471 Vonafexor 1192171-69-9 100%
Vonafexor
Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
T6053 Turofexorate Isopropyl 629664-81-9
Turofexorate Isopropyl
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
T11661 INT-767 1000403-03-1 98%
INT-767
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function fo...
T77124 Osocimab 2056878-75-0 98%
Osocimab
Osocimab (BAY 1213790) is a potent anti-FXIa antibody with a Ki value of 2.4 nM and an EC50 value of 0.2 nM.Osocimab may reduce thrombosis through FXI inhibition...
T6344 Sevelamer hydrochloride 152751-57-0 98%
Sevelamer hydrochloride
Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption....
Tropifexor
T4379
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
Altenusin
T8895
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
Ursodeoxycholic acid sodium
T29078
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeox...
GSK2324
T27460
GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.
Guggulsterone
T5574
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
Cilofexor
T7436
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
Hyodeoxycholic acid
T2968
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
Vonafexor
T8471
Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
Turofexorate Isopropyl
T6053
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
INT-767
T11661
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function fo...
Osocimab
T77124
Osocimab (BAY 1213790) is a potent anti-FXIa antibody with a Ki value of 2.4 nM and an EC50 value of 0.2 nM.Osocimab may reduce thrombosis through FXI inhibition...
Sevelamer hydrochloride
T6344
Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption....
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TargetMol