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FXR

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA, which up- or down-regulates the expression of certain genes.
Cat. No. Product name CAS No. Purity Chemical Structure
TQ0252 BAR502 1612191-86-2 99.91%
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T2233 GW 4064 278779-30-9 99.94%
GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
T11428 Glyco-Obeticholic acid 863239-60-5 99.95%
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
T15806 LY2562175 1103500-20-4 99.96%
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
T1789 Obeticholic Acid 459789-99-2 99.97%
Obeticholic acid is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
T0847 Chenodeoxycholic acid 474-25-9 99.97%
Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbe...
T2202 Lithocholic acid 434-13-9 99.98%
Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubili...
BAR502
TQ0252
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
GW 4064
T2233
GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
Glyco-Obeticholic acid
T11428
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
LY2562175
T15806
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
Obeticholic Acid
T1789
Obeticholic acid is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
Chenodeoxycholic acid
T0847
Chenodiol is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbe...
Lithocholic acid
T2202
Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubili...
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