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Androgen Receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7440 P,p'-DDE 72-55-9 98%
p,p'-DDE
p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT
T3393 Triptophenolide 74285-86-2 98%
Triptophenolide
Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.
T12146 N-Desmethyl-Apalutamide 1332391-11-3 97.83%
N-Desmethyl-Apalutamide
N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.
T21740 RD162 915087-27-3 97.74%
RD162
RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).
T6400 AZD3514 1240299-33-5 96.6%
AZD3514
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
TQ0214 Dimethylcurcumin 52328-98-0 95.77%
Dimethylcurcumin
Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferatio...
T6002 Enzalutamide 915087-33-1 100%
Enzalutamide
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP). Enzalutamide activates autophagy, has antitumor activity, and is commonly u...
T75129 Luxdegalutamide 2750830-09-0 100%
Luxdegalutamide
Luxdegalutamide (ARV-766) is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades the wil...
T8117 Metenolone acetate 434-05-9 100%
Metenolone acetate
Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow ...
TN1805 Isosilybin B 142796-22-3 100%
Isosilybin B
Isosilybin B is a flavonolignan extracted from silymarin that exhibits anti-prostate cancer (PCA) activity, inhibits cancer cell proliferation, and contributes t...
T2991 3,3'-Diindolylmethane 1968-05-4 100%
3,3'-Diindolylmethane
3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.
T67818 BMS-641988 100%
BMS-641988
BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.
T13187 Topterone 60607-35-4 100%
Topterone
Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in cast...
T15750 Ligandrol 1165910-22-4
Ligandrol
Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.
T29111 VPC-13566 218464-59-6
VPC-13566
VPC-13566 is a BF3-specific small molecule, which effectively inhibited the androgen receptor transcriptional activity and displaced the BAG1L peptide from the B...
T10359 AR antagonist 1 1818885-54-9
AR antagonist 1
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PR...
T24943 VPC-14228 19983-28-9 98%
VPC-14228
VPC-14228 is a specific AR-DBD inhibitor that acts by inhibiting both Y594A and Q592A mutants.
T8860 DSRM-3716 58142-99-7 98%
DSRM-3716
Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a...
T39695 ARD-2128 2222111-87-5 98%
ARD-2128
ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) degrader of the androgen receptor (AR), effectively diminishing AR protei...
T13312L Seviteronel 1610537-15-9 98%
Seviteronel
Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist for the study of breast and prostate cancer.
p,p'-DDE
T7440
p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT
Triptophenolide
T3393
Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.
N-Desmethyl-Apalutamide
T12146
N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.
RD162
T21740
RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).
AZD3514
T6400
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
Dimethylcurcumin
TQ0214
Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferatio...
Enzalutamide
T6002
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP). Enzalutamide activates autophagy, has antitumor activity, and is commonly u...
Luxdegalutamide
T75129
Luxdegalutamide (ARV-766) is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades the wil...
Metenolone acetate
T8117
Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow ...
Isosilybin B
TN1805
Isosilybin B is a flavonolignan extracted from silymarin that exhibits anti-prostate cancer (PCA) activity, inhibits cancer cell proliferation, and contributes t...
3,3'-Diindolylmethane
T2991
3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.
BMS-641988
T67818
BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.
Topterone
T13187
Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in cast...
Ligandrol
T15750
Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.
VPC-13566
T29111
VPC-13566 is a BF3-specific small molecule, which effectively inhibited the androgen receptor transcriptional activity and displaced the BAG1L peptide from the B...
AR antagonist 1
T10359
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PR...
VPC-14228
T24943
VPC-14228 is a specific AR-DBD inhibitor that acts by inhibiting both Y594A and Q592A mutants.
DSRM-3716
T8860
Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a...
ARD-2128
T39695
ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) degrader of the androgen receptor (AR), effectively diminishing AR protei...
Seviteronel
T13312L
Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist for the study of breast and prostate cancer.
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TargetMol