wnk

WNK-IN-7 is a potent and selective WNK1 kinase inhibitor.

WNK-IN-3 is a novel allosteric inhibitor of WNK kinase.

WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)

WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1 2 3 4).

WNK1-IN-1, a selective inhibitor of WNK1, exhibits an IC50 value of 1.6 μM and also inhibits OSR1 phosphorylation with an IC50 value of 4.3 μM, indicating its potential utility in the research of blood pressure regulation and cancer.

WNK-IN-B is an inhibitor of Wnk signalling. WNK-IN-B is a cell-permeable diaminoacridine derivative that targets the CCT domain of SPAK and OSR1 via reversible binding. WNK-IN-B selectively suppress hypotonic shock-induced WNK signaling pathway activation