whole-cell — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8372	VU0134992	VU 0134992	Potassium Channel
	VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM		Potassium Channel
T13316	VU0134992 hydrochloride		Potassium Channel
	VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 µM).		Potassium Channel
T6658	SB-408124		OX Receptor
	SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.		OX Receptor
T4367	Mycro 3	Mycro-3	c-Myc , Autophagy
	Mycro 3 is potent and selective for c-Myc in whole cell assays.		c-Myc , Autophagy
T16383	Olinciguat	IW-1701	Guanylate cyclase
	Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.		Guanylate cyclase
T76870	Narsoplimab	OMS 721	SARS-CoV
	Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody, a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 and prevents lectin pathway ac...		SARS-CoV
T12844	SB-408124 Hydrochloride		Others
	SB-408124 Hydrochloride is a non-peptide OX1 receptor antagonist(Ki of 57 nM and 27 nM in both whole cell and membrane, respectively).		Others
T61446	BioA-IN-13
	BioA-IN-13 is a highly effective inhibitor of the Mycobacterium tuberculosis BioA enzyme, displaying potent cell permeability and whole-cell activity [1].
T30990	CMFDA	5-Chloromethylfluorescein diacetate,Cell Tracker Green,CM-FDA,CM FDA
	CMFDA can be used as a fluorescent whole-cell-tracking reagent.
T11243	Ethyl tosylcarbamate		Others
	Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877).		Others
T38266	Nirogacestat dihydrobromide
	Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs. Lanz et al (2010) Pharmacodynamics and pharmaco...
T40650	Dihydroisopimaric acid
	Dihydroisopimaric acid activates BK channels alphabeta1, which are large conductance Ca 2+ activated K + channels. This compound directly measures the opening of BKalphabeta1 under a whole-cell voltage clamp.
T33407	MitoEbselen-2 chloride	MitoPeroxidase-2,MitoPeroxidase 2,MitoEbselen 2,MitoEbselen-2
	MitoEbselen-2 is a radiation mitigator which reduces lipid hydroperoxides and prevents apoptotic cell death. When administered 24 hours postirradiation, MitoEbselen-2 was shown to increase the survival of mice exposed to...
T37763	BTD
	Selective TRPC5 activator (EC50 = 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC50 = 20.6 μM for TRPM8). Also activates TR...
T26447	A 78773	A78773,A-78773
	A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tis...
T83326	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid disodium
	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid disodium, a fluorescent dye, is utilized for retrograde axonal transport demonstration, secondary antibody labeling, and as a whole cell stain [1].
T41212	FTI 277
	FTI 277 is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10μM respectively) and disrupts constitutive H-R...
T80455	ω-Conotoxin CVIB		Sodium Channel
	ω-Conotoxin CVIB is an antagonist of non-selective N- and P/Q-type voltage-gated calcium channels (VGCCs). It inhibits depolarization-activated whole-cell VGCC currents in dorsal root ganglion (DRG) neurons, exhibiting a...		Sodium Channel
T26865	BMS-933043	BMS933043
	BMS-933043 is a Selective α7 nAChR partial agonist. BMS-933043 showed potent binding affinity to native rat (Ki = 3.3 nM) and recombinant human alpha7 nicotinic acetylcholine receptors (Ki = 8.1 nM). BMS-933043 shows ago...
T63405	NAZ2329
	NAZ2329 is the first cell-permeable inhibitor of the R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), which is a variant and preferentially inhibits PTPRZ (IC50=7.5 μM for hPTPRZ1) and PTPRG (IC50=4.8...