val-ala-pab

Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing pepti

Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.

Boc-Val-Ala-PAB-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates drug-attachment to antibodies, allowing for targeted therapeutic delivery and release, thus playing a crucial role in ADC development.

MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Val-Ala-PAB-SN38 is a drug-linker conjugate for ADCs, comprising the ADC linker Val-Ala-PAB and SN38. SN-38 is the active metabolite of irinotecan, which acts as an inhibitor of topoisomerase I (TopoisomeraseI).

Mal-Val-Ala-PAB(C2-glucuronic acid)-DMEA-PNU-159682 is an active molecule-linker compound used in ADCs, consisting of a cleavable Val-Ala linker and the potent ADC cytotoxin PNU-159682.

Mc-PEG4-Val-Ala-PAB-Exatecan is a drug-linker conjugate used in ADC (antibody-drug conjugate) formulations. This compound comprises an ADC linker component (Mc-PEG4-Val-Ala-PAB) and the DNA topoisomerase I inhibitor, Exatecan.

Maleimide-Val-Ala-PAB-SNS032 is a conjugated compound used as an ADC toxin and linker. SNS032 acts as a CDK inhibitor, reducing cancer cell viability and arresting the cell cycle at the G1/S phase. Maleimide-Val-Ala-PAB functions as a cleavable ADC linker. Maleimide-Val-Ala-PAB-SNS032 is utilized in the synthesis of ADC molecules.

Fmoc-Val-Ala-PAB-PNP is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs).

SG3199-Val-Ala-PAB is an intermediate in the synthesis of Tesirine, a conjugate of agent-linker for antibody-drug conjugates (ADCs) used in cancer research [1].

Boc-Val-Ala-PAB is a cathepsin-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) [1] [2].

Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b), an antibody-drug conjugate linker (ADC linker), binds Nectin-4 polypeptides to chemotherapeutic agents for use in cancer research [1].

Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable linker used in the production of antibody-drug conjugates (ADCs), enabling the attachment of cytotoxic drugs to antibodies for targeted delivery [1].

Val-Ala-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), composed of the Val-Ala-PAB cleavable linker and MMAE, a potent microtubule inhibitor. It is designed to be cleaved by Cathepsin B within cancer cells, releasing MMAE to inhibit tubulin polymerization and induce apoptosis. This mechanism reduces toxicity to normal tissues while enhancing antitumor activity.

Compound D7, also known as Mal-PEG8-Val-Ala-PAB-SB-743921, is a drug-linker conjugate for antibody-drug conjugates (ADC). It comprises the KSP inhibitor SB-743921 connected through a linker and is utilized in the synthesis of ADCs [1].

Mal-amido-PEG8-Val-Ala-PAB-SG3200 is an antibody-drug conjugate (ADC) linker[1].

Mal-amido-PEG9-Val-Ala-PAB-SG3200 is a cleavable ADC linker conjugate employed in the production of antibody-drug conjugates (ADCs) [1].

4-Pentynoyl-Val-Ala-PAB-PNP, a cleavable ADC linker used for synthesizing cryptophycin conjugates [1], is a click chemistry reagent that contains an alkyne group. It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.

Compound B7-H4-ADC (Mal-amido-PEG8-Val-Ala-PAB-SG3199) is a Drug-Linker Conjugate for ADC that not only inhibits cancer cell proliferation but also induces apoptosis, arrests the cell cycle, and damages DNA [1].

Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag is an ADC (antibody-drug conjugate) linker compound.

Alloc-Val-Ala-PAB-PNP is a cleavable ADC linker.

Mal-Val-Ala-PAB-NMe-CH2CH2-O-CO-Dazostinag is an ADC (antibody-drug conjugate) linker conjugate.

m-PEG8-Lys(Mal)-Val-Ala-PAB-Ph-CO-Dazostinag is an ADC linker-drug conjugate.

4-Pentynoyl-Val-Ala-PAB is a click chemistry reagent that contains an azido group. Click chemistry holds immense potential for binding among nucleic acids, lipids, proteins, and other molecules. It is widely used in various research fields due to benefits such as high yield, high specificity, and simplicity.