val ala pab

Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing pepti

Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).

Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.

MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Alloc-Val-Ala-PAB-PNP is a cleavable ADC linker.

Boc-Val-Ala-PAB is a cathepsin-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) [1] [2].

Mc-​Val-​Ala-​PAB (GMP) refers to the GMP grade reagents of Mc-​Val-​Ala-​PAB. Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).

Val-Ala-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), composed of the Val-Ala-PAB cleavable linker and MMAE, a potent microtubule inhibitor. It is designed to be cleaved by Cathepsin B within cancer cells, releasing MMAE to inhibit tubulin polymerization and induce apoptosis. This mechanism reduces toxicity to normal tissues while enhancing antitumor activity.

Boc-Val-Ala-PAB-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates drug-attachment to antibodies, allowing for targeted therapeutic delivery and release, thus playing a crucial role in ADC development.

Compound B7-H4-ADC (Mal-amido-PEG8-Val-Ala-PAB-SG3199) is a Drug-Linker Conjugate for ADC that not only inhibits cancer cell proliferation but also induces apoptosis, arrests the cell cycle, and damages DNA [1].

Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b), an antibody-drug conjugate linker (ADC linker), binds Nectin-4 polypeptides to chemotherapeutic agents for use in cancer research [1].

Compound LE14, or Mal-Val-Ala-PAB-N(SO2Me)-Exatecan, is a conjugate of the ADC toxin Exatecan and the linker Mal-Val-Ala-PAB-N(SO2Me). This compound is utilized in the synthesis of ADC FZ-AD005. FZ-AD005 is an ADC targeting delta-like ligand 3 (DLL3, KD=58.3 pM) and exhibits antitumor activity against SCLC cancer.

Fmoc-Val-Ala-PAB-PNP is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs).

CL845-PAB-Ala-Val-C5-MC, a conjugatable STING ligand, derives from the proprietary cyclic dinucleotide CL845 and is designed for bioconjugation.

Compound D7, also known as Mal-PEG8-Val-Ala-PAB-SB-743921, is a drug-linker conjugate for antibody-drug conjugates (ADC). It comprises the KSP inhibitor SB-743921 connected through a linker and is utilized in the synthesis of ADCs [1].

Mal-amido-PEG9-Val-Ala-PAB-SG3200 is a cleavable ADC linker conjugate employed in the production of antibody-drug conjugates (ADCs) [1].

4-Pentynoyl-Val-Ala-PAB-PNP, a cleavable ADC linker used for synthesizing cryptophycin conjugates [1], is a click chemistry reagent that contains an alkyne group. It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.

CL845-PAB-Ala-Val-PEG4-Azide is a conjugatable STING ligand, synthesized from the proprietary cyclic dinucleotide [CL845]. It can be utilized for bioconjugation.

SG3199-Val-Ala-PAB is an intermediate in the synthesis of Tesirine, a conjugate of agent-linker for antibody-drug conjugates (ADCs) used in cancer research [1].

Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable linker used in the production of antibody-drug conjugates (ADCs), enabling the attachment of cytotoxic drugs to antibodies for targeted delivery [1].

m-PEG8-Lys(Mal)-Val-Ala-PAB-Ph-CO-Dazostinag is an ADC linker-drug conjugate.

Mal-Val-Ala-PAB-NMe-CH2CH2-O-CO-Dazostinag is an ADC (antibody-drug conjugate) linker conjugate.

Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag is an ADC (antibody-drug conjugate) linker compound.

4-Pentynoyl-Val-Ala-PAB is a click chemistry reagent that contains an azido group. Click chemistry holds immense potential for binding among nucleic acids, lipids, proteins, and other molecules. It is widely used in various research fields due to benefits such as high yield, high specificity, and simplicity.