val ala pab

Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing pepti

Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.

Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).

Boc-Val-Ala-PAB-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates drug-attachment to antibodies, allowing for targeted therapeutic delivery and release, thus playing a crucial role in ADC development.

MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-Val-Ala-PAB-PNP is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs).

Mc-​Val-​Ala-​PAB (GMP) refers to the GMP grade reagents of Mc-​Val-​Ala-​PAB. Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).

CL845-PAB-Ala-Val-C5-MC, a conjugatable STING ligand, derives from the proprietary cyclic dinucleotide CL845 and is designed for bioconjugation.

CL845-PAB-Ala-Val-PEG4-Azide is a conjugatable STING ligand, synthesized from the proprietary cyclic dinucleotide [CL845]. It can be utilized for bioconjugation.

SG3199-Val-Ala-PAB is an intermediate in the synthesis of Tesirine, a conjugate of agent-linker for antibody-drug conjugates (ADCs) used in cancer research [1].

Boc-Val-Ala-PAB is a cathepsin-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) [1] [2].

Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b), an antibody-drug conjugate linker (ADC linker), binds Nectin-4 polypeptides to chemotherapeutic agents for use in cancer research [1].

Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable linker used in the production of antibody-drug conjugates (ADCs), enabling the attachment of cytotoxic drugs to antibodies for targeted delivery [1].

Val-Ala-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), composed of the Val-Ala-PAB cleavable linker and MMAE, a potent microtubule inhibitor. It is designed to be cleaved by Cathepsin B within cancer cells, releasing MMAE to inhibit tubulin polymerization and induce apoptosis. This mechanism reduces toxicity to normal tissues while enhancing antitumor activity.

Compound D7, also known as Mal-PEG8-Val-Ala-PAB-SB-743921, is a drug-linker conjugate for antibody-drug conjugates (ADC). It comprises the KSP inhibitor SB-743921 connected through a linker and is utilized in the synthesis of ADCs [1].

Mal-amido-PEG8-Val-Ala-PAB-SG3200 is an antibody-drug conjugate (ADC) linker[1].

Mal-amido-PEG9-Val-Ala-PAB-SG3200 is a cleavable ADC linker conjugate employed in the production of antibody-drug conjugates (ADCs) [1].

4-Pentynoyl-Val-Ala-PAB-PNP, a cleavable ADC linker used for synthesizing cryptophycin conjugates [1], is a click chemistry reagent that contains an alkyne group. It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.

Compound B7-H4-ADC (Mal-amido-PEG8-Val-Ala-PAB-SG3199) is a Drug-Linker Conjugate for ADC that not only inhibits cancer cell proliferation but also induces apoptosis, arrests the cell cycle, and damages DNA [1].

Compound LE14, or Mal-Val-Ala-PAB-N(SO2Me)-Exatecan, is a conjugate of the ADC toxin Exatecan and the linker Mal-Val-Ala-PAB-N(SO2Me). This compound is utilized in the synthesis of ADC FZ-AD005. FZ-AD005 is an ADC targeting delta-like ligand 3 (DLL3, KD=58.3 pM) and exhibits antitumor activity against SCLC cancer.

Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag is an ADC (antibody-drug conjugate) linker compound.

Alloc-Val-Ala-PAB-PNP is a cleavable ADC linker.

Mal-Val-Ala-PAB-NMe-CH2CH2-O-CO-Dazostinag is an ADC (antibody-drug conjugate) linker conjugate.

m-PEG8-Lys(Mal)-Val-Ala-PAB-Ph-CO-Dazostinag is an ADC linker-drug conjugate.