type-i

Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.

Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.

Type-I/-II Photosensitizer-1 (compound 8b) is a photosensitizer with anticancer properties. It exhibits significant phototoxicity against A549 and 4T1 tumor cells. Under laser irradiation, Type-I/-II Photosensitizer-1 demonstrates strong oxygen-independent antitumor activity with an IC50 ranging from 1.50 to 1.76 μM.

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is an IgG1, κ inhibitor derived from mice, targeting denatured collagen type-I in both human and mouse.

Type-II-IN-1 (Compound 3) is a Type II spleen tyrosine kinase (Syk) inhibitor with an IC50 value of 2.1 nM. Type-II-IN-1 binds to the DFG-out conformation of Syk, and it may be applied in immunology studies, including research on asthma.

Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.

Vitamin D3 (cholecalciferol) is a naturally occurring form of vitamin D; once metabolically activated, it can induce cellular differentiation and cancer cell proliferation. Vitamin D3 can be used to establish kidney stone models and is also an important research target in the fields of immunology and oncology.

Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).

Collagenase Type I is a proteolytic enzyme that primarily targets collagen and is able to break down peptide bonds in collagen. Collagenase is used as a potential therapeutic option to break up the herniated disc material, thereby reducing compression of nearby nerves. Collagenase may aid in the breakdown and reorganization of excessive scar tissue, potentially improving tissue function and appearance. Collagenase has the potential to treat intervertebral disc herniation, keloid, fat mass, lipoma, as well as Peyronie's disease and palmar fibromatosis.

Collagen, Type I, from bovine achilles tendon is a type I collagen derived from bovine achilles tendon, which is widely found in marine invertebrate tissues. Collagen, Type I, from bovine achilles tendon is the only component of collagen fibers that make up the dermis, and plays a major role in bone and connective tissue. connective tissues, and functions primarily by forming and maintaining the integrity of the skeleton.

HPMC (Type II,Viscosity:100000mPa.s) is a water-soluble hydrophilic, non-ionic cellulose ether.

Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and glucose uptake into cells and inhibits synthesis of glucose by the liver. Biguanides may antagonize the action of glucagon, thus reducing fasting glucose levels.

Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.

Type III-Intermediate 8 is a useful organic compound for research related to life sciences and the catalog number is T9562.

Type III-Intermediate7 is a useful organic compound for research related to life sciences and the catalog number is T9563.

Miglustat (NB-DNJ) is an alkylated product of imino sugar deoxynojirimycin.It is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).

VI 16832 is a broad-spectrum Type I kinase inhibitor used for comparative expression analysis of protein kinases across cancer cell lines, enabling the quantification of relative kinase abundance. VI 16832 has been employed to analyze over 170 protein kinases in multiple SILAC-encoded cancer cell lines, providing a versatile tool for kinase signaling studies and pharmacological research.

LDN-214117 is a potent and selective ALK2 inhibitor.

Collagenase Type II, an endopeptidic matrix metalloproteinase MMP-8 derived from the bacterium Clostridium histolyticum, preferentially degrades type I collagen and is commonly used in tissues requiring high digestive efficiency such as pancreas and liver.

Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels and is used to study ventilatory failure caused by apnea of ​​prematurity and exacerbation of chronic obstructive pulmonary disease.

PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.

Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.

Methacrylated Type I collagen (Col1MA) is a methacrylate-modified scaffold material used in tissue engineering, retaining the fundamental properties of natural collagen. In the presence of photoinitiator LAP, it self-assembles into a fibrous hydrogel, targeting bioactive adhesion sites to inherently support tissue cells and offer biodegradability. Applications include cell culture, bio 3D printing, and tissue engineering.