tubulin-inhibitory — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1753	D-64131		Microtubule Associated
	D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.		Microtubule Associated
T11917	Lys-SMCC-DM1	Lys-Nε-MCC-DM1	Microtubule Associated
	DM1 is a tubulin inhibitor. Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is the active metabolite of DM1.		Microtubule Associated
T77651	Tubulin polymerization-IN-47		Microtubule Associated
	Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 an...		Microtubule Associated
T3S0209	Vincristine		ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
	Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hemato...		ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
T61459	Tubulin inhibitor 19
	Tubulin inhibitor 19 (compound 9b) is a potent indole chalcone compound that exhibits strong inhibitory activity against tubulin. Its potential in cancer research makes it valuable for studying cancer diseases [1].
T39139	PARP1-IN-6	PARP1-IN-6
	PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μM for PARP-1.
T61242	Tubulin inhibitor 12
	Tubulin inhibitor 12 (Hit 9) is a recently developed compound with potent inhibitory effects on tubulin (IC50 = 25.3 μM). This compound exhibits noteworthy anti-tumor and anti-proliferative activities, making it a promis...
T72449	Tubulin inhibitor 31
	Tubulin Inhibitor 31 is a potent compound with an inhibitory concentration (IC 50) of 4 µM, demonstrating significant anti-proliferative activity and the ability to inhibit HUVEC migration.
T72719	Tubulin/MMP-IN-2
	Tubulin/MMP-IN-2, a dual inhibitor of tubulin and matrix metalloproteinases (MMPs), effectively inhibits tubulin polymerization and induces cell apoptosis. It demonstrates inhibitory activities against MMP-2, MMP-3, and ...
T63513	Antitumor agent-71
	Antitumor Agent-71 is an antitumor compound that exhibits an inhibitory effect on tubulin aggregation. antitumor Agent-71 possesses an anti-proliferative effect with IC50 values ranging from 3.98-15.70 μM against tumor c...
T61433	HDAC1-IN-5
	HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 an...
T22631	Dolastatin 10 trifluoroacetate		Others
	Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerizati...		Others
T40348	TTBK1-IN-1	TTBK1-IN-1
	TTBK1-IN-1 is a highly potent and selective inhibitor of tau tubulin kinase 1 (TTBK1), capable of penetrating the blood-brain barrier with ease. With an IC 50 value of 2.7 nM, TTBK1-IN-1 exhibits strong inhibitory activi...
T63696	HDAC-IN-9
	HDAC-IN-9 is a potent and selective dual inhibitor of tubulin and HDAC. HDAC-IN-9 exhibits inhibitory effects on the invasion and migration of A549 cells. HDAC-IN-9 exhibits potent anti-tumor and anti-angiogenic activiti...
T71252	PC-046
	PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti...
T61696	EGFR-IN-57
	EGFR-IN-57 (Compound 25a) is a potent, orally active inhibitor of EGFR tyrosine kinase (EGFR-TK) with an IC50 of 0.054 μM. Additionally, it exhibits inhibitory activity against VEGFR-2, CK2α, topoisomerase IIβ, and tubul...
T73581	HI5
	HI5, a potent inhibitor of tubulin and indoleamine 2,3-dioxygenase (IDO), exhibits an inhibitory concentration (IC50) of 70 nM in HeLa cells. It suppresses IDO expression, reduces kynurenine production, and enhances T ce...