target/Indoleamine_2,3_Dioxygenase_(IDO)/1

1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride (1-PPZ-DHC) is a compound used as a molecular structural unit. It is an analog of the natural product piperazine and has a wide range of biological activities, including anti-inflammatory, anti-tumor and antibacterial activities. It has also been studied for the treatment of neurological disorders such as Alzheimer's and Parkinson's.

1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.

IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.

rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.

Target 1 has a wide range of applications in life science related research.

1-(2,3-Dichlorphenyl)-piperazine (DCPP) is a potent DHCR7 inhibitor. DHCR7 is the last enzyme in cholesterol biosynthesis.

The compound 6-[(1R,2S)-2,3-dihydroxy-1-methoxy-3-methylbutyl]-7-methoxy has been isolated from the stem of Angelica dahurica, marking its first discovery from a plant source [1].

IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively.)

(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].

1-Ethylpiperazine-2,3-dione is a useful organic compound for research related to life sciences. The catalog number is T67665 and the CAS number is 59702-31-7.

N4-Benzoyl-1-(6-O-DMTr-2,3-dideoxy-beta-D-erythro-hexopyranosyl)cytosine is a useful organic compound for research related to life sciences. The catalog number is TNU1623 and the CAS number is 145594-00-9.

N-[1-(2,3-Dioleyloxy)propyl]-N,N,N-trimethylammonium (chloride) is a useful organic compound for research related to life sciences and the catalog number is T67179.

1-(2,3-Dideoxy-2,3-didehydro-a-D-erythro-hexo pyranosyl) cytosine is a useful organic compound for research related to life sciences. The catalog number is TNU1622 and the CAS number is 199599-71-8.

4-Amino-5-cyano-1-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine, a purine nucleoside analogue, exhibits widespread antitumor efficacy, particularly against indolent lymphoid malignancies. Its anticancer properties primarily stem from the inhibition of DNA synthesis and the induction of apoptosis, among other mechanisms [1].

3’-N-modified nucleoside

Nucleoside Derivatives - 7-Deaza-purine nucleosides; Scaffolds and Templates

(R)-8-(Benzyloxy)-5-(2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)quinolin-2(1H)-one is a useful organic compound for research related to life sciences and the catalog number is T66254.

2,3-Dichloro-1-propanol-d5 is a deuterated compound of 2,3-Dichloro-1-propanol. 2,3-Dichloro-1-propanol has a CAS number of 616-23-9.

4-[(2,3-Dihydroxy-3-methyl-1-oxobutoxy)methyl]phen is a useful organic compound for research related to life sciences. The catalog number is T125047 and the CAS number is 321722-02-5.

Azido-nucleoside; 3’-N-modified nucleoside

N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a useful organic compound for research related to life sciences. The catalog number is T67192 and the CAS number is 923036-30-0.

(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol methanesulfonate is a useful organic compound for research related to life sciences. The catalog number is T67219 and the CAS number is 1175536-50-1.

7-Chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione is a useful organic compound for research related to life sciences. The catalog number is T64627 and the CAS number is 2252403-82-8.

5-O-Benzoyl-4-C-hydroxymethyl-2,3-O-isopropylidene-1-O-methyl-beta-D-ribofuranose is a Carbohydrate Derivative.

1-(Chloromethyl)-1-methyl-4-(2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperazinium chloride is a useful organic compound for research related to life sciences and the catalog number is T64494.

Phenol, m-(2,3-dipropyl-1-methyl-3-pyrrolidinyl)- is a bioactive chemical.

IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).

Phenol, m-(2,3-dipropyl-1-methyl-3-pyrrolidinyl)-, acetate is a bioactive chemical.

(R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetic acid is a useful organic compound for research related to life sciences. The catalog number is T65534 and the CAS number is 63422-71-9.

Nucleoside Derivatives - 7-Deaza-purine nucleoside; Scaffolds an Templates

Beta-D-homoDNA-C(Bz)-phosphorami dite; N4-Benzoyl-1-[6-O-DMTr-2,3-dideoxy-4-(O-CED-phosphoramitidyl)-beta-D-erythro-hexopyranosyl)cytosine is a useful organic compound for research related to life sciences and the catalog number is TNU1624.

5,6-Dimethoxy-2-(pyridin-4-ylmethylene)-2,3-dihydro-1H-inden-1-one is a useful organic compound for research related to life sciences. The catalog number is T66785 and the CAS number is 4803-74-1.

2,3-Dimethyl-4-nitropyridine 1-oxide is a useful organic compound for research related to life sciences. The catalog number is T65951 and the CAS number is 37699-43-7.

(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67324 and the CAS number is 900160-98-7.

α-2,3-sialyltransferase-IN-1 is a noncompetitive inhibitor of α-2,3-sialyltransferase(IC50 of 6 μM).

1-(2,3-Dideoxy-β-D-erythro-hexo pyranosyl)cytosine is a useful organic compound for research related to life sciences. The catalog number is TNU0597 and the CAS number is 136020-18-3.

Phenol, m-(1-allyl-2,3-dimethyl-3-piperidyl)-, hydrobromide is a bioactive chemical.

4-C-Hydroxymethyl-2,3-O-isopropylidene-1-O-methyl-beta-D-ribofuranose is a Carbohydrate Derivative.