tagging

KKL-35 is an inhibitor of trans-translation (IC50: 0.9 µM) with broad-spectrum antibiotic activity.

N6-Allyladenosine (N Allyladenosine), a novel small molecule for RNA tagging identified by mutation assays, is a nucleoside analogue with antimicrobial and anticancer activity that shows cytotoxicity against mammalian tumor cells and can be used in the study of breast cancer.

Nitrilotriacetic acid (Nitriloacetate) is a chelator that tracks and enriches His-tagged proteins in living cells by reacting with divalent metal ions-mediated 6His tagging.

Tris(benzyltriazolylmethyl)amine (TBTA) is a tertiary amine with three 1,2,3-triazole groups that complexes with and stabilizes copper(I), thereby accelerating azide-alkyne cycloadditions used in click chemistry.

PySAHA is a versatile HDAC inhibitor that degrades intracellular HDAC through a hydrophobic tagging mechanism. It also exhibits photodynamic therapeutic activity, generating reactive oxygen species upon light exposure. PySAHA inhibits breast cancer cell proliferation and migration while inducing apoptosis (apoptosis). The compound has antitumor properties valuable for breast cancer research.

ALK degrader 1 is a potent degrader using hydrophobic tagging technology (HyT), relying on the ubiquitin-proteasome system to degrade EML4-ALK with a DC50 of 0.13 μM. It demonstrates superior ALK degradation and antiproliferative effects in ALK-dependent cell lines, with no significant cytotoxicity in ALK fusion-negative cells. The compound induces G0/G1 cell cycle arrest and promotes apoptosis, efficiently degrades ALK proteins, and blocks key downstream signaling pathways such as STAT3. Additionally, ALK degrader 1 effectively induces EML4-ALK degradation in vivo and is suitable for researching ALK-related diseases.

LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the CDK9 inhibitor, SNS 032, linked to a hydrophobic tag via a glycol linker. Notably, LL-K9-3 does not affect the degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). Tested in 22RV1 cells, it effectively reduces androgen receptor (AR) and cMyc expression by inducing the selective and synchronous degradation of CDK9 and cyclin T1.

PLLA4000-PEG3000-RhB is a polylactic acid derivative with terminal rhodamine labeling. It can be utilized for tagging nanomicelles to monitor drug release in vivo in real-time.

PLLA3000-PEG2000-RhB is a polylactic acid derivative with terminal rhodamine labeling. This compound can be utilized for tagging nanomicelles to monitor drug release in vivo in real time.

PLLA3000-PEG1000-RhB, a polylactic acid derivative with terminal rhodamine labeling, can be utilized for tagging nanomicelles to enable real-time monitoring of drug release in vivo.

PLLA2000-PEG1000-RhB is a polylactic acid derivative endowed with a rhodamine label at its terminal. This compound can be utilized for tagging nanomicelles to facilitate the real-time monitoring of drug release within biological systems.

PLLA1000-PEG2000-RhB is a polylactic acid derivative with terminal rhodamine labeling. This compound is useful for tagging nanomicelles to enable real-time monitoring of drug release in vivo.

Biotin-16-dGTP tetralithium is a biotin-labeled dGTP used for tagging oligonucleotides.

Cys-His Tag is a bifunctional protein tag that integrates cysteine residues with a histidine tag. This tag can be employed to enhance tagging specificity or to introduce a covalent binding site.

Bovine beta-1,4-galactosyltransferase 1 (Y289L) (Bovin B4GALT1 (Y289L)) is a mutated galactosyltransferase derived from cattle with a mutation at the Y289L gene locus. This enzyme labels O-GlcNAcylated proteins with an N-azidoacetylgalactosamine (GalNAz) group. This labeling technique enables specific, unbiased, and global tagging of O-GlcNAcylated proteins. After labeling, the attached azide group can react with various alkyne-modified chemical probes, facilitating a range of downstream analyses.

ARP (Aldehyde reactive probe) is a chemical compound that serves as an aldehyde-reactive probe by specifically tagging AP sites in DNA with biotin residues. It is used to detect abasic sites, which are common forms of DNA damage and intermediates in mutagenesis and carcinogenesis. ARP is highly sensitive, capable of detecting abasic sites at the femtomolar level (fewer than 1 site per 10^4 nucleotides).

MTSSL (Otmpmms) is a highly reactive, thiol-specific spin label employed for tagging thiol residues in proteins to study protein structure and dynamics, as well as protein-protein interactions.

8-Diazomethyl quinoline (8-DMQ) is a labeling reagent used for tagging acyl-CoAs (acyl-Coenzyme A). The use of 8-Diazomethyl quinoline enhances detection sensitivity.