tagging

N6-Allyladenosine (N Allyladenosine), a novel small molecule for RNA tagging identified by mutation assays, is a nucleoside analogue with antimicrobial and anticancer activity that shows cytotoxicity against mammalian tumor cells and can be used in the study of breast cancer.

Nitrilotriacetic acid (Nitriloacetate) is a chelator that tracks and enriches His-tagged proteins in living cells by reacting with divalent metal ions-mediated 6His tagging.

Tris(benzyltriazolylmethyl)amine (TBTA) is a tertiary amine with three 1,2,3-triazole groups that complexes with and stabilizes copper(I), thereby accelerating azide-alkyne cycloadditions used in click chemistry.

KKL-35 is an inhibitor of trans-translation (IC50: 0.9 µM) with broad-spectrum antibiotic activity.

LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the CDK9 inhibitor, SNS 032, linked to a hydrophobic tag via a glycol linker. Notably, LL-K9-3 does not affect the degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). Tested in 22RV1 cells, it effectively reduces androgen receptor (AR) and cMyc expression by inducing the selective and synchronous degradation of CDK9 and cyclin T1.

PLLA4000-PEG3000-RhB is a polylactic acid derivative with terminal rhodamine labeling. It can be utilized for tagging nanomicelles to monitor drug release in vivo in real-time.

PLLA3000-PEG2000-RhB is a polylactic acid derivative with terminal rhodamine labeling. This compound can be utilized for tagging nanomicelles to monitor drug release in vivo in real time.

PLLA3000-PEG1000-RhB, a polylactic acid derivative with terminal rhodamine labeling, can be utilized for tagging nanomicelles to enable real-time monitoring of drug release in vivo.

PLLA2000-PEG1000-RhB is a polylactic acid derivative endowed with a rhodamine label at its terminal. This compound can be utilized for tagging nanomicelles to facilitate the real-time monitoring of drug release within biological systems.

PLLA1000-PEG2000-RhB is a polylactic acid derivative with terminal rhodamine labeling. This compound is useful for tagging nanomicelles to enable real-time monitoring of drug release in vivo.

ARP (Aldehyde reactive probe) is a chemical compound that serves as an aldehyde-reactive probe by specifically tagging AP sites in DNA with biotin residues. It is used to detect abasic sites, which are common forms of DNA damage and intermediates in mutagenesis and carcinogenesis. ARP is highly sensitive, capable of detecting abasic sites at the femtomolar level (fewer than 1 site per 10^4 nucleotides).