skeletal muscle atrophy

Sabinene is a natural product that has antifungal and anti-inflammatory properties

MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor used to study conditions linked to muscle wasting, encompassing both skeletal and cardiac muscle atrophy [1].

Trevogrumab (REGN-1033) is a fully human monoclonal antibody specifically designed to target and inhibit the activity of growth differentiation factor 8 (GDF8), which is also known as myostatin and functions as a negative regulator of muscle growth;Trevogrumab is currently under extensive research of sarcopenia, a complex condition characterized by progressive and generalized loss of skeletal muscle mass and function often associated with aging, wasting atrophy, various chronic diseases, and significant alterations in dietary and nutritional intake.

Myostatin inhibitory peptide 2 is a 24-amino-acid peptide derived from amino acids 20-43 of the mouse myostatin prodomain, and serves as a potent myostatin inhibitor. Myostatin inhibitory peptide 2 binds directly to myostatin with high affinity (Kd=35.9 nM), blocks the binding of myostatin to ActRII receptor, and inhibits the activation of downstream Smad2 signaling pathway. In mdx mice, a model of muscular dystrophy, Myostatin inhibitory peptide 2 significantly increases skeletal muscle weight and is suitable for research on mechanisms and interventions of muscular atrophy diseases.