sesquiterpenoid

Curcumol ((-)-Curcumol), a pure monomer derived from Rhizoma Curcumaeis, exhibits antitumor activities.

Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene has anti-allergic, anti-inflammatory, anti-melanogenic, and antioxidant activities. Valencene inhibits the overexpression of Th2 chemokines and pro-inflammatory chemokines by blocking the NF-κB pathway.

Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively)

Patchouli alcohol (Patchoulol) is a naturally occurring tricyclic sesquiterpenoid found in patchouli oil. It is a key bioactive component known for its immunomodulatory, anti-inflammatory, antioxidant, antitumor, antibacterial, anti-atherosclerotic, antiemetic, and sedative properties.

Hinesol is a unique sesquiterpenoid isolated from Atractylodes lancea rhizome. Hinesol has been found to induce apoptosis through the JNK signaling pathway in HL-60 cells.

(Rac)-β-Chamigrenic acid is a racemic form of the sesquiterpenoid β-Chamigrenic acid, extracted from S. chinensis.

Heptelidic acid (Koningic acid) is a sesquiterpenoid lactone antibiotic derived from the probiotic fungus Aspergillus oryzae, a selective GAPDH inhibitor. It downregulates caspase to inhibit etoposide-induced apoptosis. Heptelidic acid inhibits tau fibrillation in a concentration-dependent manner and exerts antitumor effects on extra-intestinal melanoma by controlling glyceraldehyde-3-phosphate dehydrogenase activity.

Chlorfortunone A, a novel sesquiterpenoid dimer isolated from the roots of Chloranthus fortunei, inhibits transforming growth factor (TGF)-β activity [1].

Chloranthalactone B, a lindenane-type sesquiterpenoid from the Chinese medicinal herb Sarcandra glabra, inhibits inflammatory mediator production by suppressing the AP-1 and p38 MAPK pathways [1].

Geranylacetone (Geranyl acetone) is a sesquiterpenoid isolated from Ferula akitschkensis stems that reduces parasite burden in infected animals and can be used in studies of Trypanosoma congolense infections Geranylacetone is used as an antioxidant in the Spondylidinae subfamily Geranylacetone can be used as a pheromone component in the Spondylidinae subfamily of California longhorn beetles.

Cangorinine E-1 (compound 11), a dihydroagarofuran sesquiterpenoid derivative, exhibits weak inhibitory effects on herpes simplex virus type II (HSV) [1].

Sterpurol D, a sterpurane sesquiterpenoid compound, significantly inhibits nitric oxide (NO) production [1].

Nardoguaianone K, a guaiane-type sesquiterpenoid isolated from the roots of Nardostachys chinensis, has potential applications in pancreatic cancer research [1] [2].

Linderanine C ((-)-Linderanine C) (compound 6), a sesquiterpenoid, is extractable from the roots of Wuyao [1].

Leocarpinolide F, a sesquiterpenoid naturally derived from Siegesbeckia orientalis [1], exhibits an ability to inhibit (anti-feedant) and demonstrates significant insecticidal activity (toxicity) against plant herbivore pests such as Spodoptera littoralis larvae.

Kanshone C, a sesquiterpenoid found in the roots of Nardostachys chinensis [1], exhibits noteworthy biological properties.

Eremofortin B, a sesquiterpenoid synthesized by Penicillium roqueforti, is also known as PR Toxin (PRT) [1].

Desacetylxanthanol (Compound 4), a sesquiterpenoid originating from Xanthium strumarium, exhibits anti-tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) activity [1].

6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, exhibits cytotoxicity against HL-60 and MOLT-3 leukemia cell lines, with half maximal inhibitory concentrations (IC50s) ranging from 4.1 to 5.4 μM [1].

1α-Hydroxy-3-deoxypseudoanisatin (Iso-γ-fagarine), a sesquiterpenoid, is derived from the peel of star anise (Illicium merrillianum) and has been isolated as noted in reference [1].

Compound 7, 1α, 2α-Diacetoxy-8β-isobutanoyloxy-9α-benzoyloxy-15-β-(β-furancarbonyloxy)-4β, 6β-dihydroxy-β-dihydroagarofuran, is an eudesmane-type sesquiterpenoid located in the root bark of Pseudolarix kaempferi [1].

1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran is a sesquiterpenoid isolated from the root bark of Tripterygium hypoglaucum, characterized by benzoyl and cinnamoyl groups [1].

(2E)-Leocarpinolide F (Compound 20), a germacrane-type sesquiterpenoid, is isolated from Sigesbeckia orientalis [1].

Kanshone A, a sesquiterpenoid naturally derived from Nardostachys chinensis, is cytotoxic and inhibits the proliferation of P-388 leukemia cells.