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Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.

[(2-Di-tert-butylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)-2-(2'-amino-1,1'-biphenyl)]palladium(II) methanesulfonate is a useful organic compound for research related to life sciences. The catalog number is T64584 and the CAS number is 1536473-72-9.

(tBuBrettPhos Pd(allyl))TfOH salt is a useful organic compound for research related to life sciences and the catalog number is T64621.

BrettPhos Pd G4 is a useful organic compound for research related to life sciences. The catalog number is T64764 and the CAS number is 1599466-83-7.

AdBrettPhos Pd G3 is a useful organic compound for research related to life sciences and the catalog number is T67255.

Piperettine is an active compound found in pepper.

Amber Musk, an alpha-hydrogen aldehyde, exhibits beef/cooked potato/creamy flavors and occurs in foods like anise, oats, and passion fruit.

Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.

Citric acid (Citro) is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a food additive and a natural preservative.

Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-HT2B, and 5-HT7 receptors with Kis of 0.19 nM and 2.7 nM, respectively. Brilaroxazine can be used for research about cognitive impairments in neuropsychiatric and neurological diseases.

GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively.

RET/TRKA-IN-1 (Compound 13) is a dual inhibitor targeting RET with an IC50 of 0.375 µM and TRKA. It reduces cell viability of LC-2 and KM12, with GI50 values of 0.72 and 0.25 µM respectively. RET/TRKA-IN-1 also induces cell cycle arrest at the G1 phase.

Musk ambrette (Standard) is the standard substance of Musk ambrette, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments.

KCC2 Modulator-3 (Example 54) is a KCC2 modulator with an EC50 of 0.253 μM. It is applicable in the study of neurological disorders such as epilepsy, neuropathic pain, and Rett syndrome.

KIT-13 is an orally active acetal phospholipid derivative that effectively inhibits neuroinflammation and addresses mitochondrial DNA leakage issues associated with Mecp2 deficiency. It significantly alleviates neurological symptoms and prolongs lifespan in Rett Syndrome (RTT) model mice. KIT-13 is valuable for research in RTT and other neuroinflammation-related conditions.

Choline is a vital nutrient essential for maintaining liver, neurological, hematological, and skeletal muscle balance. It serves as a precursor in the biosynthesis of membrane phospholipids, like phosphatidylcholine, which aid in cell signaling and membrane transport, and is also a precursor to the neurotransmitter acetylcholine. Choline is crucial for hepatic lipid transport. In animal studies, perinatal administration of choline (18.8 mg/kg) has been shown to enhance cognitive function impaired by prenatal alcohol exposure in rats. Additionally, choline (13 mg/animal per day) improves motor coordination and addresses behavioral issues in a mouse model of Rett syndrome, and mitigates recognition memory deficits caused by early-life iron deficiency in rats when provided in drinking water at 5 ppm. Low choline intake is linked to muscle wasting, and dietary choline (1,000 mg/kg) boosts leg and breast muscle protein content in broiler chickens.

VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome (RTT).

Trofinetide, derived from the neuroprotective tripeptide Gly-Pro-Glu (an N-terminal sequence of insulin-like growth factor-1, IGF-1), shows promise in various neuroprotective models. At a concentration of 10 nM, it mitigates cell death in primary rat embryonic striatal neurons caused by okadaic acid. Additionally, Trofinetide reduces the expression of pro-inflammatory markers (IL-1β, TNF-α, IL-6, and E-selectin) in a rat model simulating neuroinflammation from penetrating ballistic-like brain injuries. In cases of brain injury induced by middle cerebral artery occlusion (MCAO), administration of Trofinetide at 30 and 60 mg/kg reduces the area of cortical and striatal infarct. Furthermore, a daily dose of 100 mg/kg reverses social recognition and contextual fear conditioning deficits, diminishes the number of dendritic spines, and decreases testicular weight gain in an fmr1-/- knockout mouse model of fragile X syndrome. Trofinetide formulations have been employed in treating Rett syndrome, highlighting its versatility across various neurological conditions.