radiotherapy — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0987	Gimeracil	Gimestat	Autophagy
	Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.		Autophagy
TN2108	Protohypericin		Others
	Protohypericin, a naphthodianthrone derivative found in the plant Hypericum perforatum, exhibits photocytotoxicity and is utilized in tumor necrosis targeted radiotherapy through its radioiodinated form.		Others
T2589	Dolasetron Mesylate hydrate	Dalasetron Mesylate Hydrate	5-HT Receptor
	Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) , a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radioth...		5-HT Receptor
T77764	DC-Y13-27		Others
	Dc-y13-27, a derivative of DC-Y13, is a potent YTHDF2 inhibitor (KD: 37.9 μM). DC-Y13-27 has antitumor activity that enhances the response of radiotherapy and immunotherapy to tumors.		Others
T2610L	BMS-599626 2HCL(714971-09-2 Free base)	BMS 599626 dihydrochloride,BMS-599626 2HCL(714971-09-2 Free base),AC480 2HCl	HER
	BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferat...		HER
T2265	Bimiralisib	5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2	Others , PI3K , S6 Kinase , mTOR
	Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to ...		Others , PI3K , S6 Kinase , mTOR
T3S2344	β,β-Dimethylacrylshikonin	Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK , HIF/HIF Prolyl-Hydroxylase
	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...		ERK , HIF/HIF Prolyl-Hydroxylase
T31977	GLYN	NSC 137875,NSC137875,Glycidyl nitrate,NSC-137875
	GLYN, a nitric oxide donor, acts by enhancing the therapeutic efficacy of chemotherapy and radiotherapy.
T27052	CMP3a	CMP-3a,CMP 3a
	CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destab...
T14035	3M-011		TLR
	3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibit...		TLR
T21310	Nimustine	Nimustine Hydrochloride,Nidran,pimustine hydrochloride,ACNU 50,Nimustine HCl,ACNU
	NIMUSTINE, an antineoplastic agent especially effective against malignant brain tumors, has been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
T3182L	L-778123 free base	L-778,123,L 778123,L-778123,L778123,L 778,123
	L-778123 is an inhibitor of FPTase and GGPTase-I. The combination of L-778123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer.
T81424	Polysaccharidase	Tremella polysaccharide
	Polysaccharidase (Tremella polysaccharide), a fungal polysaccharide, exhibits immunoenhancing properties and holds potential for research in mitigating chemotherapy and radiotherapy-induced leukopenia [1] [2].
T61370	DNA-PK-IN-6
	DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 ampli...
T70134	L-778123 Dihydrochloride
	L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity...
T21119	Cevimeline	AF-102B,FKS 508,SNI 2011,HSDB 7286
	Cevimeline, a parasympathomimetic and muscarinic agonist, affects M1 and M3 receptors. Cevimeline has been shown to treat dry mouth and Sj gren's syndrome. It is also used to reduce Xerostomia symptoms and increase saliv...
T69922	EPZ020411 HCl
	EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies. EPZ020411 suppresses RCC1 argin...
T61751	DNA-PK-IN-3
	DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tum...
T68663	GPI-15427
	GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiform...
T62191	DNA-PK-IN-5
	DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits the activity of DNA-PKcs, significantly reduces tumour DNA repair and induces apoptosis. DNA-PK-IN-5 improves the sensitivity of tumour tissue to radiothe...