r 140

IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation (IC50 of 10 nM) and inhibiting tumour tissue D2HG levels.IDH2R140Q-IN-2 is suitable for the study of acute myeloid leukaemia (AML).

IDH2R140Q-IN-1 is a potent inhibitor of IDH2R140Q (IC50: 6.1 nM) and can be used in studies of acute myeloid leukemia.

(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.

SR 140333 is a NK1 receptor antagonist.

Alfadolone acetate is a gamma-aminobutyric acid (GABA) receptor agonist.

2-Chlorobenzonitrile ,with CAS No. 873-32-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Chlorobenzonitrile provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone ,with CAS No. 394-32-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2,3-Dihydrobenzofuran-7-carboxylic acid ,with CAS No. 35700-40-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2,3-Dihydrobenzofuran-7-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(1,5-Dimethyl-1H-pyrazol-3-yl)methanol ,with CAS No. 153912-60-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (1,5-Dimethyl-1H-pyrazol-3-yl)methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Phenylpyridine ,with CAS No. 939-23-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Phenylpyridine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Ethyl 4-methylbenzoate ,with CAS No. 94-08-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Ethyl 4-methylbenzoate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-(1H-pyrazol-1-yl)aniline ,with CAS No. 17635-45-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(1H-pyrazol-1-yl)aniline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Indole-5-carboxylic acid, 98% ,with CAS No. 1670-81-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Indole-5-carboxylic acid, 98% provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Chloroisonicotinamide ,with CAS No. 100859-84-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Chloroisonicotinamide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-(Methylthio)nicotinic acid ,with CAS No. 74470-23-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-(Methylthio)nicotinic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-Chloro-1,3-dimethylpyrazole ,with CAS No. 54454-10-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Chloro-1,3-dimethylpyrazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1,3-Dimethyl-5-pyrazolone ,with CAS No. 2749-59-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,3-Dimethyl-5-pyrazolone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Methyl-3-furoic acid ,with CAS No. 6947-94-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Methyl-3-furoic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(1-Methyl-1H-imidazol-2-yl)methanol ,with CAS No. 17334-08-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (1-Methyl-1H-imidazol-2-yl)methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1H-Imidazole-4-carboxylic acid ,with CAS No. 1072-84-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1H-Imidazole-4-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1H-Benzotriazole ,with CAS No. 95-14-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1H-Benzotriazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-trans-Hydroxycyclohexylamine ,with CAS No. 27489-62-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-trans-Hydroxycyclohexylamine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(S)-1-(4-chlorophenyl)ethylamine ,with CAS No. 4187-56-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (S)-1-(4-chlorophenyl)ethylamine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Methyl 6-methylnicotinate ,with CAS No. 5470-70-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Methyl 6-methylnicotinate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.