prion

TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.

Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

Anti-Mouse/Human PrP/prion protein Antibody (TW1) is an IgG2a antibody inhibitor derived from mice, targeting mouse or human PrP/prion protein.

Prion peptide fragment that exhibits neurotoxicity

Prion Protein (106-126) (human) (scrambled) represents a disordered sequence of Prion Protein (106-126). It shares the same amino acid composition with the active segment of Prion Protein (106-126), but its sequence is randomly scrambled. This variant is commonly utilized as a negative control.

Prionoid E is a useful organic compound for research related to life sciences and the catalog number is T124011.

Prionoid D is a useful organic compound for research related to life sciences and the catalog number is T124012.

Prionoid C is a useful organic compound for research related to life sciences and the catalog number is T124013.

Prionoid B is a useful organic compound for research related to life sciences and the catalog number is T124014.

Salprionin is a useful organic compound for research related to life sciences and the catalog number is T125601.

Prionitin is a natural product from Salvia prionitis Hance.

Prionidipene A is a natural product for research related to life sciences. The catalog number is TN5590 and the CAS number is 2199455-72-4.

Prionanthoside is a natural product for research related to life sciences. The catalog number is TN6502 and the CAS number is 161842-81-5.

NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3, enhances the aggregation of misfolded prion protein NT219 affects the levels of certain molecular chaperones and inhibits STAT3 phosphorylation NT219 is useful for the study of cancer and neurodegenerative diseases.

Tetracycline is an orally active broad-spectrum antibiotic that exhibits inhibitory activity against various Gram-positive and Gram-negative bacteria, as well as Chlamydia, Mycoplasma, and Rickettsia. It is commonly used in anti-infection research and can also be used to induce tumor regression based on BCR-ABL gene silencing.

TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.

PrPSc-IN-1 is a fluorescent probe that binds to the misfolded protein PrPSc, inhibits its accumulation with an IC50 of 1.6 μM, and exhibits anti-prion activity.

GFP16 is a compound with potential prion antiviral activity, used in prion research.

SM875 is a degrader specifically targeting the cellular prion protein (PrP) with an IC50 of 7.87 μM. By binding to the folding intermediates of PrP, SM875 facilitates their degradation via the autophagy-lysosome pathway. It acts exclusively on nascent, immature PrP molecules and does not affect mature PrP synthesized beforehand. SM875 has the potential to inhibit prion replication, making it a promising compound for research in neurodegenerative diseases, particularly prion diseases.

Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM) and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an e

DB772 is a broad-spectrum antiviral activity that inhibits Bovine Viral Diarrhea Virus (BVDV), prion activity, Border Disease Virus (BDV), HoBi Virus, Forked Horn Virus and Bungowannah Virus.

IND24 has anti-prion activity and can be used to study neurodegenerative diseases.

IND81 is an antiprion agent that works by extending the lives of prion-infected animals.