prion

TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.

Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

Anti-Mouse/Human PrP/prion protein Antibody (TW1) is an IgG2a antibody inhibitor derived from mice, targeting mouse or human PrP/prion protein.

Prion peptide fragment that exhibits neurotoxicity

Prion Protein (106-126) (human) (scrambled) represents a disordered sequence of Prion Protein (106-126). It shares the same amino acid composition with the active segment of Prion Protein (106-126), but its sequence is randomly scrambled. This variant is commonly utilized as a negative control.

Prion Protein (118-135), human, is the 118-135 fragment of the human prion protein. This compound can induce apoptosis and stimulate the activity of caspase-3 and caspase-9. It exhibits cytotoxicity towards retinal neurons and possesses neurotoxic properties.

Tetracycline is an orally active broad-spectrum antibiotic that exhibits inhibitory activity against various Gram-positive and Gram-negative bacteria, as well as Chlamydia, Mycoplasma, and Rickettsia. It is commonly used in anti-infection research and can also be used to induce tumor regression based on BCR-ABL gene silencing.

Prionoid E is a useful organic compound for research related to life sciences and the catalog number is T124011.

Prionoid D is a useful organic compound for research related to life sciences and the catalog number is T124012.

Prionoid C is a useful organic compound for research related to life sciences and the catalog number is T124013.

Prionoid B is a useful organic compound for research related to life sciences and the catalog number is T124014.

Salprionin is a useful organic compound for research related to life sciences and the catalog number is T125601.

Prionitin is a natural product from Salvia prionitis Hance.

Prionidipene A is a natural product for research related to life sciences. The catalog number is TN5590 and the CAS number is 2199455-72-4.

Prionanthoside is a natural product for research related to life sciences. The catalog number is TN6502 and the CAS number is 161842-81-5.

NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3, enhances the aggregation of misfolded prion protein NT219 affects the levels of certain molecular chaperones and inhibits STAT3 phosphorylation NT219 is useful for the study of cancer and neurodegenerative diseases.

TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.

PrPSc-IN-1 is a fluorescent probe that binds to the misfolded protein PrPSc, inhibits its accumulation with an IC50 of 1.6 μM, and exhibits anti-prion activity.

GFP16 is a compound with potential prion antiviral activity, used in prion research.

SM875 is a degrader specifically targeting the cellular prion protein (PrP) with an IC50 of 7.87 μM. By binding to the folding intermediates of PrP, SM875 facilitates their degradation via the autophagy-lysosome pathway. It acts exclusively on nascent, immature PrP molecules and does not affect mature PrP synthesized beforehand. SM875 has the potential to inhibit prion replication, making it a promising compound for research in neurodegenerative diseases, particularly prion diseases.

Chloroguanabenz (acetate) is an antiprion agent derived from guanabenz, an α2-adrenergic receptor agonist. It inhibits prion formation in vitro in both yeast and mammalian models. Additionally, Chloroguanabenz (acetate) reduces levels of the truncated huntingtin protein derivative Htt48 in HEK293T cells and is used for studying Huntington's disease.

(R)-SM875 is a degrader that targets the folding intermediates of prion proteins (PrP). It significantly reduces PrP levels with an IC50 of 3 μM. (R)-SM875 can be utilized in prion disease research.

Erisonersen is an antisense oligonucleotide that inhibits the synthesis of prion proteins (PrP). It is employed in the study of prion diseases.

Erisonersen sodium is an antisense oligonucleotide that inhibits the synthesis of prion protein, used in the study of prion diseases.