pnh

Iptacopan hydrochloride (LNP023 hydrochloride) is a small-molecule inhibitor and a complement factor B inhibitor (IC50 = 10 nM, KD = 7.9 nM) with high selectivity, oral activity, and cell permeability, used for the treatment of complement-mediated diseases including paroxysmal nocturnal hemoglobinuria, IgA nephropathy, and C3 glomerulopathy.

COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with an MIC90 of 26 μM. It disrupts bacterial cell wall and membrane integrity, possesses intracellular permeability, and lacks mitochondrial toxicity.

MANT-GppNHp is a competitive inhibitor of adenylyl cyclase (AC) and a fluorescently labeled GTP analog. It interacts with a hydrophobic pocket near the AC catalytic site through its MANT group, directly obstructing the binding of the substrate ATP. MANT-GppNHp can be utilized in studies of diseases such as cholera, which are associated with increased AC activity.

Fmoc-Asp-NH2 is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

DNP-NH-PEG2-C2-acid is a PEG-based linker for PROTACs, which connects two essential ligands critical for PROTAC molecule formation, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DNP-NH-PEG4-C2-Boc is a PEG-based linker used in PROTACs, which joins two essential ligands crucial for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

4-N3Pfp-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

PC SPDP-NHS carbonate ester is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].

Antho-rwamide I is an anthozoan neuropeptide.

LysoFP-NH2 is the fluorescent form of the lysosomal turn-on fluorescent probe for carbon monoxide (CO) lysoFP-NO2 . LysoFP-NH2 is formed when lysoFP-NO2 reacts with CO. It displays excitation/emission maxima of 440/528 nm, respectively.

H-Trp-NH2.HCl ((2S)-2-amino-3-(1H-indol-3-yl)propanamide hydrochloride) is an endogenous metabolite that has been detected in various biological fluids, e.g. Urine and blood.

SNAP8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2) is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation.

β-Aminopropionitrile hydrochloride is a selective, orally available, irreversible inhibitor of lysyl oxidase (LOX) that reduces metastatic seeding potential in MDA-MB-231 breast cancer cells.

SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor. Human cutaneous mast cells express PAR-3 mRNA, implicating a role in itch mechanotransduction, with both histamine-dependent and independent pathways reported. While PAR-3 alone does not induce itch, it may potentiate itch when co-expressed with PAR-4, enhancing thrombin's action. This suggests that PAR-3's primary function is not as a signal transmitter across the membrane, but rather as a cofactor necessary for PAR-4 activation.

STE-MEK1(13), a cell-permeable ERK1/2 inhibitor with IC50 values ranging from 13 to 30 μM, impedes the phosphorylation of ERK1/2, as demonstrated in studies [1] [2].

p-NH2-CHX-A-DTPA is a bifunctional chelating agent [1].

RW2, an antimicrobial peptide, demonstrates activity against E. coli and S. aureus, with IC50 values of 730 µM and 210 µM, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes.

RW3, an antimicrobial peptide, exhibits activity against E. coli and S. aureus with IC50 values of 16 µM and 8 µM, respectively. Additionally, it induces hemolysis in isolated ovine erythrocytes.

RW4, an antimicrobial peptide, exhibits activity against E. coli and S. aureus, with IC50 values of 9.6 and 5.1 µM, respectively. Additionally, it induces hemolysis of isolated ovine erythrocytes.

Super-chelating agent & MRI contrast agent

Ac-LEVDGWK(Dnp)-NH2 serves as a substrate for Caspase-3 and is utilized to measure the enzyme's activity.

Ac-SDKP is a natural tetrapeptide with anti-inflammatory and anti-fibrotic properties.

Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 (compound 5) is a selective hMC5R antagonist ligand with an IC50 of 10 nM.

FITC-Acp-RpYTPEP-NH2 is a potent fluorescent tracer. It exhibits binding affinity for the Cbl-b SH2 domain (Kd = 0.07 μM). Fluorescence polarization assays utilizing FITC-Acp-RpYTPEP-NH2 can be employed to assess inhibitors of the Cbl-b SH2 domain.