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Search Results for " p62 "

Targets

11

Compounds

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T13809 P62-mediated mitophagy inducer PMI Mitophagy
P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy .
T8970 ML162 Ferroptosis , GPX , Glutathione Peroxidase
ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)
T13360 XRK3F2 Autophagy
XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
T27709 K67 K 67,K-67
K67 is a specific inhibitor against the interaction between KEAP1 DC domain and S349-phosphorylated KIR of p62/SQSTM1.
T72560 Antitumor agent-81
Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Addi...
T83945 XIE62-1004
XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62. This interaction promotes p62 self-aggregation and its subsequent interaction with LC3 on autophagoso...
T76040 Dusquetide TFA
Dusquetide (SGX942) TFA, a first-in-class innate defense regulator (IDR), modulates the innate immune response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by interac...
T76372 TRAF6 peptide
TRAF6 peptide, a specific TRAF6-p62 inhibitor, effectively inhibits NGF-dependent TrkA ubiquitination, showcasing strong research potential for neurological conditions including Alzheimer's disease (AD), Parkinson's, ALS...
T78221 TRAF6 peptide TFA E1/E2/E3 Enzyme
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates promising research applications in various neurological disorde...
T13667 Dusquetide TFA (931395-42-5 free base) SGX942 TFA,Dusquetide TFA Others
Dusquetide TFA is a kind of innate defense regulator (IDR).Dusquetide TFA has been shown to be active in reducing inflammation and increasing clearance of bacterial infections.Dusquetide TFA regulates innate immune respo...
T60453 TrxR-IN-3
TrxR-IN-3 (Compound 2c) is a effective TrxR inhibitor. TrxR-IN-3 shows strong antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and l...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00345 IGF2BP-2 Protein, Human, Recombinant (His) Human E. coli
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition motif) domains. IGF2BP2 binds to...
TMPH-01788 NFE2L2 Protein, Human, Recombinant (His) Human E. coli
Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzyme...
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