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Cat No. | Product Name | Synonyms | Targets |
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T72026 | p53-MDM2-IN-1 | Mdm2 , p53 | |
p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM. This compound holds potential for applications in anti-tumor research. | |||
T67698 | p53-Mdm2 inhibitor 4 | Mdm2 , p53 | |
p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction. | |||
T72771 | p53 Activator 7 | ||
P53 Activator 7 is an activator of the p53 Y220C mutation (MDM-2/p53), featuring an EC50 value of 104 nM. It has the capability to bind to the mutated p53, reinstating its DNA-binding function. | |||
T80233 | p53 CBS | p53 Consensus binding sequence | |
p53 CBS (p53 Consensus binding sequence), a biologically active peptide, functions as the p53 consensus DNA binding site. | |||
TP1794 | p53 (17-26) | p53 17-26 | |
This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2. | |||
T24440 | MDM2-p53-IN-1b | MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b | |
MDM2-p53-IN-1b is the MDM2-p53 interaction inhibitor. | |||
T12351 | p53 and MDM2 proteins-interaction-inhibitor (racemic) | p53-and-mdm2-proteins-interaction-inhibitor-racemic | Others |
p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins. | |||
T67858 | STIMA-1 | 2-Vinylquinazolin-4-ol,p53 Activator VII | Others |
STIMA-1 (2-Vinylquinazolin-4-ol), an active compound, can restore the activity of p63. STIMA-1 can stimulate the proliferation and differentiation of keratinocytes. | |||
TP2281 | p53 tumor suppressor fragment | Others | |
p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial ... | |||
T72770 | p53 Activator 5 | ||
P53 Activator 5 is a potent activator of p53, exhibiting a SC150 value of less than 0.05 mM. It effectively binds to mutant p53, restoring its DNA-binding capability. Additionally, P53 Activator 5 demonstrates significan... | |||
T12350 | p53 and MDM2 proteins-interaction-inhibitor dihydrochloride | Others | |
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins. | |||
T72769 | p53 Activator 3 | ||
p53 Activator 3 is a potent activator of p53, demonstrating notable efficacy with an SC150 value of less than 0.05 mM. It effectively binds to mutant p53, reinstating its DNA-binding capability, and exhibits anti-tumor a... | |||
T72877 | p53-HDM2-IN-1 | ||
p53-HDM2-IN-1 is a potent inhibitor of the p53-HDM2 protein-protein interaction, demonstrating an inhibitory concentration (IC 50) of 0.103 μM. This compound has significant applications in cancer research. | |||
T61369 | p53 Activator 2 | ||
p53 Activator 2 (compound 10ah) intercalates into DNA, causing significant DNA double-strand breaks and upregulates the expression of p53, p-p53, CDK4, and p21, leading to cell cycle arrest at the G2/M phase. It induces ... | |||
T64079 | Mutant p53 modulator-1 | ||
Mutant p53 modulator-1 is a mutant p53 modulator. mutant p53 modulator-1 is able to hinder the progression of cancers containing p53 mutations. | |||
T72832 | MDM2-p53-IN-16 | ||
MDM2-p53-IN-16 is a potent inhibitor of the MDM2-p53 complex, exhibiting an IC 50 value of 4.3 nM for the dissociation of the human p53/MDM2 complex. It effectively reactivates p53, leading to apoptosis and cell-cycle ar... | |||
T63373 | S100A2-p53-IN-1 | ||
S100A2-p53-IN-1 (compound 51), an inhibitor of S100A2-p53 interactions, targets S100A2, a Ca 2+ binding protein involved in cell signaling and commonly upregulated in pancreatic cancer. This compound effectively inhibits... | |||
T74935 | MDM2/4-p53-IN-2 | ||
MDM2/4-p53-IN-2 (2q) is a potent dual inhibitor of MDM2/MDM4 and activator of p53, demonstrating IC50 values of 70.7 nM for MDM2-p53 and 81.4 nM for MDM4-p53 complexes. It facilitates cell cycle regulation, promotes apop... | |||
T22980 | MIRA-1 | p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor | DNA/RNA Synthesis , p53 |
MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM. | |||
T74936 | MDM2/4-p53-IN-3 | ||
MDM2/4-p53-IN-3, an inhibitor of MDM2/4-p53 protein-protein interactions (PPIs), exhibits potent activity with IC50 values of 18.5 nM for MDM2-p53 and 14.8 nM for MDM4-p53. This compound is applicable in cancer research,... | |||
T34830 | Tetrofosmin | P 53,P53 | |
Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. | |||
TP2299 | Tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] | Others | |
Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA... | |||
T63438 | Rel-MDM2/4-p53-IN-3 | ||
rel-MDM2/4-p53-IN-3 is an MDM2/4-p53 protein-protein interaction (PPI) inhibitor that acts on MDM2-p53 and MDM4-p53 with IC50 values of 18.5 nM and 14.8 nM, respectively. rel-MDM2/4-p53-IN-3 can be used to study cancers,... | |||
T63748 | Rel-MDM2/4-p53-IN-2 | ||
rel-MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/MDM4 inhibitor and p53 activator that acts on both the MDM2-p53 complex (IC50: 70.7 nM) and the MDM4-p53 complex (IC50: 81.4 nM). rel-MDM2/4-p53-IN-2 is capable of regulatin... | |||
T21578 | NSC 66811 | Mdm2 | |
NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53... | |||
T7057 | Methylstat | Histone Demethylase , Others | |
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD... | |||
T27029 | Cjoc42 | cjoc 42,cjoc-42 | |
Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated w... | |||
T6610 | XI-006 | NSC 207895 | Mdm2 , p53 |
XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. | |||
T12257 | NSC 146109 hydrochloride | Apoptosis , Others | |
NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer. | |||
T9698 | UC2288 | Mdm2 , p53 | |
UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability. | |||
T1887 | Inauhzin | INZ | Sirtuin |
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54... | |||
T16523L | PhiKan 083 | Mdm2 | |
PhiKan 083 is a carbazole derivative | |||
T9122 | XL177A | DUB | |
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism. | |||
T1873 | Tenovin-3 | Tenovin3 | Sirtuin |
Tenovin-3 acts as a p53 activator. | |||
T8774 | MS7972 | Epigenetic Reader Domain | |
MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM | |||
T2464 | ZMC1 | p53 | |
NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM). | |||
T6910 | NSC59984 | p53 | |
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation. | |||
T7703 | PK11007 | Reactive Oxygen Species , p53 | |
PK11007 is an anti-p53 drug. | |||
T24730 | Roslin 2 bromide | Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2 | FAK , p53 |
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects. | |||
T16350 | NSC-87877 | Apoptosis , Phosphatase | |
NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26). | |||
T39233 | SIRT7 inhibitor 97491 | Sirtuin | |
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway. | |||
T3289 | Amifostine | Ethyol,WR2721,Gammaphos | Others , HIF/HIF Prolyl-Hydroxylase |
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity. | |||
T12472 | Pifithrin-α, p-Nitro, Cyclic | PFN-α | p53 |
Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53. | |||
T4459 | PK11000 | DNA Alkylator/Crosslinker | |
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53. | |||
T17204 | UNC0321 | Histone Methyltransferase | |
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays. | |||
T21773 | SP-141 | SP 141 | Mdm2 |
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. | |||
T2354 | UNC 0631 | UNC0631 | Histone Methyltransferase |
UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM). | |||
T8554 | KCC-07 | DNA Alkylator/Crosslinker | |
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenes... | |||
T6879 | LLY-507 | LLY507,LLY 507 | Histone Methyltransferase |
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2. | |||
T6381 | Amifostine trihydrate | Ethyol trihydrate,WR2721,Amifostine | Others , HIF/HIF Prolyl-Hydroxylase |
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5061 | Lumichrome | 7,8-Dimethylalloxazine | Others |
Lumichrome (7,8-Dimethylalloxazine) is a natural metabolite of riboflavin. Lumichrome produced by Rhizobium and other bacterial species induces major developmental changes in plants at nanomolar concentrations. Lumichrom... | |||
T8678 | Naphthazarin | 5,8-Dihydroxy-1,4-naphthoquinone,DHNQ | Apoptosis |
Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter... | |||
T0132 | Etoposide | VP-16,VP-16-213 | Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy |
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy. | |||
T4036 | Solasodine | Solancarpidine,Purapuridine,Solasodin | Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal |
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma... | |||
T5429 | Theaflavin 3,3'-digallate | 8-Gingerol,TFDG | Virus Protease , Antioxidant , HIV Protease , HSV |
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul... | |||
T3798 | Ziyuglycoside I | Gouguside 7,Ziyu-glycoside I,3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester,Zigu-glucoside I,Kudinoside H | Apoptosis , Others |
Ziyuglycoside I (Gouguside 7) has anti-inflammatory activity, could be used as an active ingredient for cosmetics. | |||
T6S1917 | Schisandrol B | Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B | P450 , Reactive Oxygen Species , Autophagy |
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a... | |||
TN6771 | Malabaricone B | Others | |
Malabaricone B is a Spice-derived phenolic, it induces mitochondrial damage in lung cancer cells via a p53-independent pathway. | |||
T30969 | Clitocine | Apoptosis , BCL | |
Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carryin... | |||
T5S0168 | Atractylenolide II | 2-Atractylenolide,Asterolide | Apoptosis , ERK , p38 MAPK , Akt , STAT |
1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK and Akt inactivation, p53 dependent. | |||
T6S1780 | Protosappanin B | Q-100961,FT-0689654 | Apoptosis |
1. Protosappanin B (Q-100961) significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, vi... | |||
T2140 | Parthenolide | (-)-Parthenolide | Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy |
(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions. | |||
T5S0331 | Isoliquiritin | Neoisoliquritin | p53 , Antifungal |
1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dependent pathway and shows crosstalk betwee... | |||
T7027 | EURYCOMANONE | Pasakbumin A | Others |
Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p... | |||
T0983 | Penicillamine | d-penicillamin,Dimethyl Cysteine,Artamine,D-(-)-Penicillamine | Antibiotic |
Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl a... | |||
TN1620 | Eriocalyxin B | Apoptosis , cAMP , NF-κB , STAT | |
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inh... | |||
T6717 | Vanillin | Lioxin,m-Methoxy-p-hydroxybenzaldehyde,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,FEMA 3107 | Others , Endogenous Metabolite |
Vanillin (Zimco) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.Vanillin can reversibly and non-competitively inhibit the cellulase activity at appropr... | |||
T6917 | Oleuropein | Apoptosis , Aromatase , ROS , PPAR | |
Oleuropein is an antioxidant polyphenol isolated from olive leaf. | |||
T5S0045 | Isofraxidin | 6,8-Dimethoxyumbelliferone,Phytodolor | MMP , ERK , p38 MAPK , TLR , COX |
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote... | |||
T6S1369 | Vitexin | Apigenin-8-C-glucoside | Antioxidant |
1. Vitexin has antinociceptive and antispasmodic activities. 2. Vitexin exhibits a prominent first-pass effect. 3. Vitexin has antioxidant, antimyeloperoxidase, and α-glucosidase inhibitory activities. 4. Vitexin can eit... | |||
T5S0055 | Chelidonine | Helidonine,Khelidonin,Stylophorin | Apoptosis , Others , Influenza Virus |
1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model ... | |||
T2179 | Triptolide | PG490,NSC 163062 | Apoptosis , Mdm2 , HSP , NF-κB |
Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and ... | |||
T1221 | Acetylcholine chloride | ACh chloride,Pilofrin | Calcium Channel , Endogenous Metabolite , AChR |
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen... | |||
T6S0221 | Eriocitrin | eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside | Apoptosis , Carbonic Anhydrase |
1. Eriocitrin (Eriodictyol-7-O-Rutinoside) is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in a rat model of high-fat diet.... | |||
TN4250 | Imbricatolic acid | p53 | |
Imbricatolic acid can prevent cell cycle progression in p53-null CaLu-6 cells. | |||
T79991 | Condurango glycoside A | ||
Condurango glycoside A activates p53, induces ROS generation, up-regulates p53 expression, and triggers apoptosis as well as premature senescence associated with DNA damage in HeLa cells [1]. | |||
TN1688 | Ginsenoside Rs3 | p53 | |
Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells. | |||
TN1156 | (-)-Curine | p53 | |
(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status. | |||
T68731 | Myxothiazol | ||
Myxothiazol is an inhibitor of mitochondrial respiratory chain complexes III. Myxothiazol induces transcription of the p53-responsive SESN2 gene that plays an important role in stress response and homeostatic regulation. | |||
TN1354 | Aaptamine | c-Myc , TNF , p53 | |
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner. | |||
TN2123 | Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside | Hyperin 6''-gallate,Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside | MAPK , p53 |
Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways. | |||
TN2114 | Pseudoginsenoside Rh2 | ERK , Raf , p53 | |
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathway. (20Z) -Pseudoginsenoside Rh2 and (20E)-Pseudoginsenosid... | |||
T75669 | Odoroside A | ||
Odoroside A, extracted from the leaves of Nerium oleander Linn., exhibits anti-cancer properties by inducing apoptosis and cell cycle arrest via the ROS/p53 signaling pathway, resulting in tumor cell death [1]. | |||
T13764 | Lycopodine | Lipoxygenase , Caspase | |
Lycopodine, a bioactive compound derived from Lycopodium clavatum spores, effectively inhibits the proliferation of HeLa cells through the induction of apoptosis. This process is mediated by caspase-3 activation. In refr... | |||
T40483 | 8-Aminoadenosine | 8-NH2-Ado | |
8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. Furthermore, it effectively obstructs Akt/mTOR signaling, inducing autophagy... | |||
TN5201 | Uncarinic acid E | BCL , MEK , Caspase , PI3K , Antifection , p53 | |
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixtu... | |||
TN4774 | Physalin A | ERK , BCL , p38 MAPK , NF-κB , Androgen Receptor , ROS , JAK , JNK , STAT , p53 , Autophagy | |
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and dow... | |||
T38036 | Lumisterol | ||
Lumisterol (9β,10α-Ergosterol), a steroid compound and the (9β,10α)-stereoisomer of Ergosterol, serves as a photoprotective agent shielding against UVB-induced DNA damage and exhibits anti-proliferative activities[1]. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02228 | p53 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli |
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and... | |||
TMPH-01075 | p53 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... | |||
TMPH-03264 | p53 Protein, Rat, Recombinant (His) | Rat | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... | |||
TMPH-02574 | p53 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... | |||
TMPY-01125 | MDMX Protein, Human, Recombinant (His) | Human | E. coli |
MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows str... | |||
TMPY-03601 | PDRG1 Protein, Human, Recombinant (His) | Human | E. coli |
PDRG1, also known as C2orf126, belongs to the prefoldin subunit beta family. It is predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs. PDRG1 may play a role in chapero... | |||
TMPY-01561 | PIG3 Protein, Human, Recombinant (His) | Human | E. coli |
Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of ca... | |||
TMPY-05896 | Influenza A H3N2 (A/swine/Thailand/CU-P53/2012) Hemagglutinin/HA Protein (His) | H3N2 | HEK293 |
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two... | |||
TMPJ-00022 | LGALS7 Protein, Human, Recombinant | Human | E. coli |
The Galectin family of proteins, with specificity for Nacetyllactosamine containing glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs).They also poss... | |||
TMPH-01520 | HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc) | HIV-1 | E. coli |
During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ... | |||
TMPY-02527 | p53R2 Protein, Human, Recombinant (His) | Human | E. coli |
Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase... | |||
TMPY-03564 | TSPAN8 Protein, Human, Recombinant (His) | Human | HEK293 |
Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a nega... | |||
TMPY-01289 | DDR1 Protein, Human, Recombinant (His) | Human | HEK293 |
Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracell... | |||
TMPY-04333 | LRRC15 Protein, Human, Recombinant (hFc) | Human | HEK293 |
LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmemb... | |||
TMPY-00369 | LY6D Protein, Human, Recombinant (mFc) | Human | HEK293 |
LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of... | |||
TMPY-02030 | CD82 Protein, Human, Recombinant (His) | Human | HEK293 |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetras... | |||
TMPY-05688 | Human respiratory syncytial virus (RSV) Fusion Protein (aa 1-525, His) | RSV | Baculovirus-Insect Cells |
Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneum... | |||
TMPY-01078 | Human respiratory syncytial virus (RSV) (A2) Fusion glycoprotein/RSV-F Protein (His) | RSV | Baculovirus-Insect Cells |
Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneum... | |||
TMPY-03236 | Human respiratory syncytial virus (RSV) Fusion protein/RSV-F (Strain RSS-2) Protein (His) | RSV | Baculovirus-Insect Cells |
Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneum... | |||
TMPY-03467 | IFN-beta Protein, Mouse, Recombinant | Mouse | HEK293 |
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras... | |||
TMPY-03145 | IFN-beta Protein, Human, Recombinant | Human | CHO |
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras... | |||
TMPY-00831 | IFN-beta Protein, Human, Recombinant (hFc) | Human | HEK293 |
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras... | |||
TMPY-03048 | PRAP1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma... | |||
TMPY-03076 | PRAP1 Protein, Human, Recombinant (His) | Human | HEK293 |
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma... | |||
TMPH-02286 | USP7 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of M... | |||
TMPH-01659 | MAGEA4 Protein, Human, Recombinant (A173T, His & Myc) | Human | E. coli |
Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis. | |||
TMPH-02630 | MDM2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional ... | |||
TMPH-01658 | MAGEA4 Protein, Human, Recombinant (His) | Human | HEK293 |
Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis. | |||
TMPY-00999 | UNC5A Protein, Human, Recombinant (His) | Human | HEK293 |
The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu... | |||
TMPY-00648 | UNC5A Protein, Human, Recombinant (hFc) | Human | HEK293 |
The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cu... | |||
TMPY-00151 | Alpha SNAP Protein, Human, Recombinant (His) | Human | E. coli |
NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to ta... | |||
TMPY-03675 | TSPAN8 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a nega... | |||
TMPH-00280 | PRKRA Protein, Bovine, Recombinant (His & Myc) | Bovine | E. coli |
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and f... | |||
TMPH-02899 | VRK1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream targe... | |||
TMPJ-01211 | EDA2R Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats ... | |||
TMPY-04904 | Zika virus (ZIKV) (strain Zika SPH2015) M/Membrane protein (Fc) | ZIKV | HEK293 |
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. ZIKV has a more selective and larger impact on the expression of genes involved in DNA replication and repair. P53 inhibit... | |||
TMPY-02211 | USP5 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Ubiquitin carboxyl-terminal hydrolase 5, also known as Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin-specific-processing protease 5, ISOT and USP5, is a member of the peptidase C19 famil... | |||
TMPH-01900 | DDX5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop r... | |||
TMPH-02221 | TRIM24 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the high... | |||
TMPH-03269 | COMMD5 Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the ... | |||
TMPJ-01278 | SENP8 Protein, Human, Recombinant (His) | Human | E. coli |
Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins ... | |||
TMPY-01463 | USP7 Protein, Human, Recombinant (aa 208-560, His & GST) | Human | Baculovirus-Insect Cells |
Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein... | |||
TMPH-00899 | Human adenovirus C serotype 5 E1B 55 kDa protein (His & Myc) | HAdV-5 | E. coli |
Plays a major role to prevent cellular inhibition of viral genome replication. Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6.... | |||
TMPY-01464 | USP7 Protein, Human, Recombinant (aa 208-560) | Human | Baculovirus-Insect Cells |
Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein... | |||
TMPY-01465 | USP7 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein... | |||
TMPJ-00675 | ZNHIT1 Protein, Human, Recombinant (His) | Human | E. coli |
ZNHIT1 belongs to the ZNHIT1 family and contains one HIT-type zinc finger. It can be phosphorylated on Thr by MAPK11 or MAPK14. ZNHIT1 is a component of the chromatin-remodeling SRCAP complex, which is composed of at lea... | |||
TMPJ-00697 | NOL3 Protein, Human, Recombinant (GST) | Human | E. coli |
Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in... | |||
TMPJ-00571 | UBE2D3 Protein, Human, Recombinant | Human | E. coli |
UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubi... | |||
TMPJ-00703 | Gankyrin Protein, Human, Recombinant | Human | E. coli |
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblast... | |||
TMPY-04023 | BCCIP Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ... | |||
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A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study; | |||
L2130 | Anti-Cancer Metabolism Compound Library | 1280 compounds | |
A unique collection of 1280 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS); | |||
L2194 | Anti-Colorectal Cancer Compound Library | 1565 compounds | |
1565 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening. |