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p53

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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p53-MDM2-IN-1
T72026381717-91-5
p53-MDM2-IN-1 (Example 30), an inhibitor of the p53-MDM2 X protein interaction, exhibits a K i value of 23.35 µM and holds potential for applications in anti-tumor research.
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6-8 weeks
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p53-Mdm2 inhibitor 4
T67698350678-63-6
p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.
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SLMP53-1
T608391643469-17-3
SLMP53-1 is a p53 activator with anti-tumor activity, inhibits wt and mutp53, activates reprogramming of glucose metabolism in xenografted human tumor tissues, and interferes with angiogenesis and migration. SLMP53-1 inhibits tumor cell growth and can be used to study human rectal cancer.
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6-8 weeks
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Rotenone
Rotocide, Rotenon, Paraderil, Dactinol, Barbasco
T297083-79-4
Rotenone (Rotocide) is a natural product and a botanical insecticide. Rotenone is a mitochondrial electron transport complex I inhibitor that promotes the production of reactive oxygen species in mitochondria and induces apoptosis.
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TargetMol | Citations Cited
c16 ceramide
Palmitoyl Ceramide, N-Palmitoylsphingosine, N-acylsphingosine, C16 Ceramide (d18:1 16:0)
T3756224696-26-2
C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.
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TargetMol | Inhibitor Hot
Ergosta-4,6,8(14),22-tetraen-3-one
TN161719254-69-4
Ergosta-4,6,8(14),22-tetraen-3-one exhibits cytotoxic activity against human gastric cancer cells and can induce G2 M cell cycle arrest and apoptosis in human hepatocellular carcinoma (HepG2) cells. These findings could facilitate the further use of various medicinal fungi in cancer treatment.
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BAY 1892005
T777682036352-13-1
BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein
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Rezatapopt
PC14586
T812892636846-41-6
Rezatapopt (PC14586) is a small molecule p53 reactivator with anti-tumor activity that selectively binds to the cleft present in the TP53 Y220C mutant protein and restores the p53 wild-type (normal) conformation and transcriptional activity, and can be used to study locally advanced or metastatic solid tumors.
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10-14 weeks
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Pseudoginsenoside Rh2
TN21141370264-16-6
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras Raf ERK p53 pathway. (20Z) -Pseudoginsenoside Rh2 and (20E)-Pseudoginsenoside Rh2 have antioxidative activity.
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7-10 days
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Pifithrin-α hydrobromide
Pifithrin-α (PFTα) HBr, Pifithrin-α, Pifithrin hydrobromide, PFTα hydrobromide, PFTα
T270763208-82-2
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.
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TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Etoposide
VP-16-213, VP-16
T013233419-42-0
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
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TargetMol | Citations Cited
BIX-01294
T7697935693-62-2
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).
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LLY-507
LLY507, LLY 507
T68791793053-37-8
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
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Alphitolic acid
Aophitolic acid
TN137919533-92-7
Alphitolic acid, a terpenoid from Potentilla freyniana Bornm, is a selective 3-hydroxy-3-methylglutamic acid coenzyme-A synthase 2 (HMGCS2) inhibitor with anti-inflammatory and anticancer activity that inhibits T cell proliferation in a concentration-dependent manner. Alphitolic acid induces apoptosis and autophagy.
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7-10 days
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Leptomycin B
LMB, CI 940
T1573587081-35-4
Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1 exportin 1 by covalent modification at a cysteine residue.
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Nutlin-3a
Nutlin-3a chiral, (−)-Nutlin-3, (-)-Nutlin-3
T6023675576-98-4
Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3a binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3a has antitumor activity.
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p53 Activator 7
T727712849340-59-4In house
p53 Activator 7 is a highly potent and cell-permeable activator of the p53 mutation Y220C (MDM-2 p53), which induces apoptosis.
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7-10 days
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Tetrofosmin
P53, P 53
T34830127502-06-1In house
Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.
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3-6 months
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tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]
TP2299
Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent tra
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p53 (17-26)
p53 17-26
TP1794488118-64-5
This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2.
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p53 and MDM2 proteins-interaction-inhibitor (racemic)
p53-and-mdm2-proteins-interaction-inhibitor-racemic
T12351939983-14-9
The racemic p53 and MDM2 proteins-interaction-inhibitor is an inhibitor of the interaction between p53 and MDM2 proteins.
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3-6 months
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Mutant p53 modulator-1
T640792746371-35-5
Mutant p53 modulator-1 is a mutant p53 modulator that hinders the progression of cancers containing p53 mutations.
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6-8 weeks
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p53-MDM2-IN-6
T2004731054506-59-0
p53-MDM2-IN-6, an LSM-83177 hydrazone analog, acts as an efficacious p53-MDM2 inhibitor with an IC50 of 11.08 µg mL. This compound inhibits the p53-MDM2 interaction leading to an increase in p-53 levels while concurrently decreasing GST enzyme expression. It halts the cell cycle at the S phase and induces early and late apoptosis (Apoptosis), exhibiting antiproliferative activity against the HT29 cell line with an IC50 of 10.44 µg mL. p53-MDM2-IN-6 holds promise for research in colorectal cancer.
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4-6 weeks
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p53 tumor suppressor fragment
TP2281
p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where i
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