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Search Results for " osteoclast "

Targets

40

Compounds

23

Natural Products

64

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T16159 Muramyl dipeptide MDP NOD
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation...
T13324 VUF11207 fumarate CXCR , Arrestin
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
T6739 Zoledronic Acid CGP-4244,CGP42446A,Zoledronate,CGP 42446,ZOL 446,Zometa Apoptosis , Rho , Autophagy
Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalc...
T21299 Zoledronic acid monohydrate zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate Apoptosis , Others , Autophagy
Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.
T1925 PLX647 c-Fms , c-Kit
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T61531 NFATc1-IN-1 RANKL/RANK
NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuc...
T0379 Risedronic Acid Risedronate Others , Transferase
Risedronic Acid (Risedronate), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption.
T9823 WAY-325398 Others
WAY-325398 is a furan derivatives. WAY-325398 inhibits osteoclast formation, inhibition rate is 14.11% at 10 μM.
T13159 Tiludronate disodium Tiludronic Acid disodium,Tiludronic acid disodium ATPase
Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disor...
T9917 Denosumab RANKL/RANK
Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand
T77567 BCPA Others
BCPA is a non-cytotoxic Pin1 modulator.BCPA modulates osteoclast activation and attenuates the reduction of Pin1 protein, thereby inhibiting RANKL-induced receptor activators of osteoclastogenesis.BCPA is used in the stu...
T27371 FR-167356 FR167356,FR 167356 ATPase
FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces b...
T2188 Thonzonium Bromide Proton pump , Antibacterial , Autophagy
Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteocl...
T69656 E197
E197 is a DOCK5 inhibitor. E197 can inhibit both mouse and human osteoclast activity. In particular, E197 prevented pathological bone loss in mice. Most interestingly, treatment with E197 did not affect osteoclast and os...
T40328 Betulinic acid derivative-1
Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM.
T26514 ABD56 ABD-56,ABD 56
ABD56 inhibits osteoclast formation and activity in vitro and in vivo.
T29109 VPC12249 VPC-12249,VPC 12249
VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity.
T26512 ABD-295
ABD-295 is an antiresorptive agent, osteoclast inhibitor, and biphenylsulfide derivative. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in ...
T72008 E09241
E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through c...
T39037 Tiludronate disodium hemihydrate Tiludronic acid disodium hemihydrate
Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound that functions as an osteoregulator. It is primarily utilized in metabolic bone disorder research. This compound acts as a po...
T83032 Anti-osteoporosis agent-7
Compound 133, also known as Anti-osteoporosis agent-7, is a potential anti-osteoporosis agent that exhibits significant inhibition of osteoclast formation.
T30089 AP-22161 AP22161,G7VE62573J,UNII-G7VE62573J,SCHEMBL7243003,AP 22161
AP-22161 selectively binds the Src SH2 domain by targeting highly conserved phosphotyrosine binding to cysteine residues in the pocket. AP-22161 selectively inhibits Src SH2 binding and can be used to inhibit osteoclast ...
T61764 Zoledronic acid disodium tetrahydrate
Zoledronic Acid (Zoledronate) disodium tetrahydrate is a potent third-generation bisphosphonate (BP), exhibiting strong anti-resorptive activity. It effectively inhibits osteoclast differentiation and apoptosis, while al...
T71480 Kahweol linoleate
Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing...
T68641 Kahweol Acetate
Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing ...
T71478 Kahweol stearate
Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing...
T68642 Kahweol palmitate
Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducin...
T71479 Kahweol oleate
Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell ...
T79472 CSF1R-IN-17 c-Fms
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM. It is capable of inhibiting osteoclast differentiation [1].
T82359 G-{d-Arg}-GDSP
G-{d-Arg}-GDSP, an RGD peptide analogue, binds to the adhesion receptor of integrins, inhibiting cellular attachment to fibronectin and osteoclast resorption [1].
T80108 Hepcidin-1 (mouse)
Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion. This compound also reduces FPN1 protein levels and boosts intra...
T73885 Methyl gerfelin
Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA...
T78208 Leramistat HMC-C-01-A,MBS2320 Mitochondrial Metabolism
Leramistat (HMC-C-01-A; MBS2320), a mitochondrial complex 1 inhibitor, plays a role in regulating cell and immune metabolism. It is effective in suppressing various conditions, including atopic dermatitis, autoimmune ski...
T78037 Hepcidin-1 (mouse) TFA
Hepcidin-1 (mouse) TFA, an endogenous peptide hormone, regulates iron homeostasis by upregulating mRNA levels of TRAP, cathepsin K, and MMP-9, enhancing TRAP-5b protein secretion, and downregulating FPN1 protein levels, ...
T81171 SH491
SH491 (Compound 33) serves as an antiosteoporosis agent, effectively inhibiting RANKL-induced osteoclast differentiation in bone-marrow-derived monocytes (BMMs) with an IC50 of 11.8 nM. Additionally, SH491 suppresses the...
T73056 Tiludronate Tiludronic acid
Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuola...
T40463 Relacatib SB-462795
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relac...
T37409 DPC-AJ1951 (trifluoroacetate salt) DPC-AJ1951 (trifluoroacetate salt)
DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogen...
T78816 Anti-osteoporosis agent-4 NF-κB
Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis. It effectively inhibits osteoclast formation, demonstrating an IC50 value of...
T83848 VnP-16 TFA
VnP-16, a synthetic peptide fragment mirroring amino acids 270-281 of vitronectin (a multifunctional glycoprotein involved in cell attachment, migration, and spreading), promotes attachment and spreading of isolated huma...

Compounds

Muramyl dipeptide
T16159
Synonym: MDP
Target: NOD
VUF11207 fumarate
T13324
Synonym:
Target: CXCR, Arrestin
Zoledronic Acid
T6739
Synonym: CGP-4244,CGP42446A,Zoledronate,CGP 42446,ZOL 446,Zometa
Target: Apoptosis, Rho, Autophagy
Zoledronic acid monohydrate
T21299
Synonym: zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate
Target: Apoptosis, Others, Autophagy
PLX647
T1925
Synonym:
Target: c-Fms, c-Kit
NFATc1-IN-1
T61531
Synonym:
Target: RANKL/RANK
Risedronic Acid
T0379
Synonym: Risedronate
Target: Others, Transferase
WAY-325398
T9823
Synonym:
Target: Others
Tiludronate disodium
T13159
Synonym: Tiludronic Acid disodium,Tiludronic acid disodium
Target: ATPase
Denosumab
T9917
Synonym:
Target: RANKL/RANK
BCPA
T77567
Synonym:
Target: Others
FR-167356
T27371
Synonym: FR167356,FR 167356
Target: ATPase
Thonzonium Bromide
T2188
Synonym:
Target: Proton pump, Antibacterial, Autophagy
E197
T69656
Synonym:
Target:
Betulinic acid derivative-1
T40328
Synonym:
Target:
ABD56
T26514
Synonym: ABD-56,ABD 56
Target:
VPC12249
T29109
Synonym: VPC-12249,VPC 12249
Target:
ABD-295
T26512
Synonym:
Target:
E09241
T72008
Synonym:
Target:
Tiludronate disodium hemihydrate
T39037
Synonym: Tiludronic acid disodium hemihydrate
Target:
Anti-osteoporosis agent-7
T83032
Synonym:
Target:
AP-22161
T30089
Synonym: AP22161,G7VE62573J,UNII-G7VE62573J,SCHEMBL7243003,AP 22161
Target:
Zoledronic acid disodium tetrahydrate
T61764
Synonym:
Target:
Kahweol linoleate
T71480
Synonym:
Target:
Kahweol Acetate
T68641
Synonym:
Target:
Kahweol stearate
T71478
Synonym:
Target:
Kahweol palmitate
T68642
Synonym:
Target:
Kahweol oleate
T71479
Synonym:
Target:
CSF1R-IN-17
T79472
Synonym:
Target: c-Fms
G-{d-Arg}-GDSP
T82359
Synonym:
Target:
Hepcidin-1 (mouse)
T80108
Synonym:
Target:
Methyl gerfelin
T73885
Synonym:
Target:
Leramistat
T78208
Synonym: HMC-C-01-A,MBS2320
Target: Mitochondrial Metabolism
Hepcidin-1 (mouse) TFA
T78037
Synonym:
Target:
SH491
T81171
Synonym:
Target:
Tiludronate
T73056
Synonym: Tiludronic acid
Target:
Relacatib
T40463
Synonym: SB-462795
Target:
DPC-AJ1951 (trifluoroacetate salt)
T37409
Synonym: DPC-AJ1951 (trifluoroacetate salt)
Target:
Anti-osteoporosis agent-4
T78816
Synonym:
Target: NF-κB
VnP-16 TFA
T83848
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T3816 Velutin NF-κB , HIF/HIF Prolyl-Hydroxylase
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ...
TN5888 Toddaculin Others
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in...
TN1040 Skullcapflavone II COX , Antibacterial , TGF-beta/Smad
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of al...
TN2347 Methylsticin Methysticin Others
Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neu...
TN1149 6''-O-acetylsaikosaponin A Others
6''-O-acetylsaikosaponin A is an acetyl saikosaponin isolated from the roots of Bupleurum chinense. Itshows some osteoclast-inhibiting activities
T2731 Usnic Acid Usniacin Antibacterial , Autophagy
Usnic Acid (Usniacin) is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces necrosis in certain cells.
T3384 Wedelolactone IKK Inhibitor II Apoptosis , NF-κB , Lipoxygenase , Caspase
Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
T3804 Neomangiferin Mangiferin 7-glucoside Phosphatase
Neomangiferin (Mangiferin 7-glucoside) has beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats. Neomangiferin and mangiferin inhibit tartrate-resistant acid phosphatase, a biochemical mar...
T3488 Tectorigenin 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine Apoptosis
Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Re...
T6S2099 Geraniin Antioxidant , TNF
1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ...
T6677 Sophocarpine ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
TN4785 Picrasidine I NF-κB , ROS , MAPK
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.
T83033 Anti-osteoporosis agent-2
Anti-osteoporosis agent-2 (Compound 10) serves as an inhibitor of osteoclast differentiation induced by RANKL [1].
TMA1743 Ergosterol peroxide ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...
TN3802 Dehydrodiconiferyl alcohol Estrogen/progestogen Receptor
Dehydrodiconiferyl alcohol (DHCA) is a lignan isolated from calabash that inhibits osteoclast differentiation and oophorectomy induced bone loss by acting as an estrogen receptor agonist.
T16846 Sauristolactam Saurolactam Others
Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated f...
T27711 Kahweol Eicosanate J002075,J 002075,J-002075
Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, ...
T79932 Eudebeiolide B Plebeiolide D NF-κB
Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is applicable in the study of osteoclast-related diseases [1].
TN2143 3,7,4'-Trihydroxyflavone Resokaempferol,5-Deoxykampferol DNA
3,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marro...
TN1663 Ganoderic acid DM PARP , Androgen Receptor , CDK
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendr...
TN4094 Gallocatechin gallate IL Receptor , NF-κB , ROS , MAPK , PPAR , Fatty Acid Synthase
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κB signaling; it also may have anti-diabeti...
TN2533 1-Hydroxy-2,3,4,7-tetramethoxyxanthone 5-HT Receptor
1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-...
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone IκB/IKK , Calcium Channel , NOS , 5-HT Receptor , COX
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type vo...

Natural Products

Velutin
T3816
Synonym:
Target: NF-κB, HIF/HIF Prolyl-Hydroxylase
Toddaculin
TN5888
Synonym:
Target: Others
Skullcapflavone II
TN1040
Synonym:
Target: COX, Antibacterial, TGF-beta/Smad
Methylsticin
TN2347
Synonym: Methysticin
Target: Others
6''-O-acetylsaikosaponin A
TN1149
Synonym:
Target: Others
Usnic Acid
T2731
Synonym: Usniacin
Target: Antibacterial, Autophagy
Wedelolactone
T3384
Synonym: IKK Inhibitor II
Target: Apoptosis, NF-κB, Lipoxygenase, Caspase
Neomangiferin
T3804
Synonym: Mangiferin 7-glucoside
Target: Phosphatase
Tectorigenin
T3488
Synonym: 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine
Target: Apoptosis
Geraniin
T6S2099
Synonym:
Target: Antioxidant, TNF
Sophocarpine
T6677
Synonym:
Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT
Picrasidine I
TN4785
Synonym:
Target: NF-κB, ROS, MAPK
Anti-osteoporosis agent-2
T83033
Synonym:
Target:
Ergosterol peroxide
TMA1743
Synonym:
Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection
Dehydrodiconiferyl alcohol
TN3802
Synonym:
Target: Estrogen/progestogen Receptor
Sauristolactam
T16846
Synonym: Saurolactam
Target: Others
Kahweol Eicosanate
T27711
Synonym: J002075,J 002075,J-002075
Target:
Eudebeiolide B
T79932
Synonym: Plebeiolide D
Target: NF-κB
3,7,4'-Trihydroxyflavone
TN2143
Synonym: Resokaempferol,5-Deoxykampferol
Target: DNA
Ganoderic acid DM
TN1663
Synonym:
Target: PARP, Androgen Receptor, CDK
Gallocatechin gallate
TN4094
Synonym:
Target: IL Receptor, NF-κB, ROS, MAPK, PPAR, Fatty Acid Synthase
1-Hydroxy-2,3,4,7-tetramethoxyxanthone
TN2533
Synonym:
Target: 5-HT Receptor
1-Hydroxy-2,3,5-trimethoxyxanthone
TN2534
Synonym:
Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00662 RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) Human E. coli
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i...
TMPJ-00607 RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) Mouse Human Cells
Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thy...
TMPJ-01252 CLEC2D Protein, Mouse, Recombinant (His) Mouse Human Cells
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and im...
TMPJ-00674 RANK/TNFRSF11A Protein, Mouse, Recombinant (His) Mouse Human Cells
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acid...
TMPJ-01466 Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His) Human Human Cells
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits ...
TMPY-02575 PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even...
TMPJ-00327 M-CSF/CSF1 Protein, Human, Recombinant (His) Human Human Cells
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and th...
TMPY-04142 RANK/TNFRSF11A Protein, Human, Recombinant (hFc) Human HEK293
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPY-04487 Osteomodulin Protein, Human, Recombinant (His) Human HEK293
Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein that belongs to the small leucine-rich proteoglycan (SLRP) family and...
TMPY-01703 TREM-2 Protein, Mouse, Recombinant (His) Mouse HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-03674 RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc) Human HEK293
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-02726 RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-00432 TREM-2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-01148 TREM-2 Protein, Human, Recombinant (His) Human HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-03364 RANKL/TNFSF11/CD254 Protein, Human, Recombinant Human HEK293
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro...
TMPY-00875 Leptin Protein, Human, Recombinant Human E. coli
Leptin is one of the most important hormones secreted by adipocytes, as an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine, and pro-inflammatory immu...
TMPH-02662 Aldolase A Protein, Mouse, Recombinant (His) Mouse Baculovirus
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator...
TMPH-02032 GPRC5A Protein, Human, Recombinant (GST) Human E. coli
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator...
TMPH-02365 JC polyomavirus (JCV) Minor capsid protein VP2 (His) JCPyV E. coli
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
TMPY-01194 OSTM1 Protein, Human, Recombinant (His) Human HEK293
Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 associat...
TMPJ-00349 RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) Human Human Cells
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANK...
TMPY-04621 OSTM1 Protein, Mouse, Recombinant (His) Mouse HEK293
Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 associat...
TMPY-01724 Osteoprotegerin Protein, Human, Recombinant (His) Human HEK293
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds t...
TMPY-03323 Osteoprotegerin Protein, Rhesus, Recombinant (hFc) Rhesus HEK293
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds t...
TMPK-00323 M-CSF/CSF1 Protein, Human, Recombinant (His & Avi) Human HEK293
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of...
TMPK-00657 SPARC Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most abundant non-collagenous protein expressed in mineralized tissues.The capacity of SPARC to influence pathways involved in extracell...
TMPY-05262 Osteoprotegerin Protein, Human, Recombinant (hFc) Human Baculovirus-Insect Cells
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds t...
TMPJ-00799 ANXA2 Protein, Human, Recombinant Human E. coli
Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression r...
TMPK-01117 OSCAR Protein, Mouse, Recombinant (hFc) Mouse HEK293
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and n...
TMPK-01092 OSCAR Protein, Human, Recombinant (hFc) Human HEK293
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and n...
TMPY-04509 Osteoprotegerin Protein, Mouse, Recombinant (hFc) Mouse HEK293
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds t...
TMPK-00324 M-CSF/CSF1 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of...
TMPY-00572 PRELP Protein, Human, Recombinant Human HEK293
PRELP (proline/arginine-rich end leucine-rich repeat protein) is a member of the leucine-rich repeat (LRR) family of extracellular matrix proteins in connective tissue. In contrast with other members of the family, the N...
TMPY-00571 PRELP Protein, Human, Recombinant (mFc) Human HEK293
PRELP (proline/arginine-rich end leucine-rich repeat protein) is a member of the leucine-rich repeat (LRR) family of extracellular matrix proteins in connective tissue. In contrast with other members of the family, the N...
TMPK-01325 M-CSF/CSF1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of...
TMPK-00322 M-CSF/CSF1 Protein, Human, Recombinant (aa 33-190) Human HEK293
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of...
TMPY-00176 FNDC4 Protein, Human, Recombinant (mFc) Human HEK293
FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of F...
TMPH-01987 PSG7 Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/u...
TMPJ-01218 M-CSF/CSF1 Protein, Rat, Recombinant Rat Human Cells
Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and different...
TMPJ-00225 Siglec-15 Protein, Mouse, Recombinant (His) Mouse Human Cells
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai...
TMPJ-00217 Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated Human Human Cells
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai...
TMPJ-01418 CSF1R Protein, Cynomolgus, Recombinant (hFc) Cynomolgus Human Cells
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l...
TMPY-03026 RANK/TNFRSF11A Protein, Rat, Recombinant (hFc) Rat HEK293
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPY-04157 RANK/TNFRSF11A Protein, Human, Recombinant (His) Human HEK293
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPJ-00434 Siglec-15 Protein, Cynomolgus, Recombinant (His) Cynomolgus Human Cells
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai...
TMPJ-01419 CSF1R Protein, Cynomolgus, Recombinant (His) Cynomolgus Human Cells
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l...
TMPY-00960 ACP5 Protein, Human, Recombinant (His) Human HEK293
Tartrate-resistant acid phosphatase (TRACP) or acid phosphatase 5, tartrate resistant (ACP5 or TRAP) is a glycosylated monomeric metalloenzyme expressed in mammals. TRACP is associated with osteoblast migration to bone r...
TMPY-01472 Osteomodulin Protein, Mouse, Recombinant (His) Mouse HEK293
Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein that belongs to the small leucine-rich proteoglycan (SLRP) family and...
TMPY-01414 ACP5 Protein, Mouse, Recombinant (His) Mouse HEK293
Tartrate-resistant acid phosphatase (TRACP) or acid phosphatase 5, tartrate resistant (ACP5 or TRAP) is a glycosylated monomeric metalloenzyme expressed in mammals. TRACP is associated with osteoblast migration to bone r...
TMPY-05514 RANK/TNFRSF11A Protein, Human, Recombinant (mFc) Human HEK293
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
TMPJ-00662
Species: Human
Expression System: E. coli
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)
TMPJ-00607
Species: Mouse
Expression System: Human Cells
CLEC2D Protein, Mouse, Recombinant (His)
TMPJ-01252
Species: Mouse
Expression System: Human Cells
RANK/TNFRSF11A Protein, Mouse, Recombinant (His)
TMPJ-00674
Species: Mouse
Expression System: Human Cells
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
TMPJ-01466
Species: Human
Expression System: Human Cells
PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
TMPY-02575
Species: Human
Expression System: Baculovirus-Insect Cells
M-CSF/CSF1 Protein, Human, Recombinant (His)
TMPJ-00327
Species: Human
Expression System: Human Cells
RANK/TNFRSF11A Protein, Human, Recombinant (hFc)
TMPY-04142
Species: Human
Expression System: HEK293
Osteomodulin Protein, Human, Recombinant (His)
TMPY-04487
Species: Human
Expression System: HEK293
TREM-2 Protein, Mouse, Recombinant (His)
TMPY-01703
Species: Mouse
Expression System: HEK293
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc)
TMPY-03674
Species: Human
Expression System: HEK293
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)
TMPY-02726
Species: Mouse
Expression System: HEK293
TREM-2 Protein, Mouse, Recombinant (hFc)
TMPY-00432
Species: Mouse
Expression System: HEK293
TREM-2 Protein, Human, Recombinant (His)
TMPY-01148
Species: Human
Expression System: HEK293
RANKL/TNFSF11/CD254 Protein, Human, Recombinant
TMPY-03364
Species: Human
Expression System: HEK293
Leptin Protein, Human, Recombinant
TMPY-00875
Species: Human
Expression System: E. coli
Aldolase A Protein, Mouse, Recombinant (His)
TMPH-02662
Species: Mouse
Expression System: Baculovirus
GPRC5A Protein, Human, Recombinant (GST)
TMPH-02032
Species: Human
Expression System: E. coli
JC polyomavirus (JCV) Minor capsid protein VP2 (His)
TMPH-02365
Species: JCPyV
Expression System: E. coli
OSTM1 Protein, Human, Recombinant (His)
TMPY-01194
Species: Human
Expression System: HEK293
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)
TMPJ-00349
Species: Human
Expression System: Human Cells
OSTM1 Protein, Mouse, Recombinant (His)
TMPY-04621
Species: Mouse
Expression System: HEK293
Osteoprotegerin Protein, Human, Recombinant (His)
TMPY-01724
Species: Human
Expression System: HEK293
Osteoprotegerin Protein, Rhesus, Recombinant (hFc)
TMPY-03323
Species: Rhesus
Expression System: HEK293
M-CSF/CSF1 Protein, Human, Recombinant (His & Avi)
TMPK-00323
Species: Human
Expression System: HEK293
SPARC Protein, Cynomolgus, Recombinant (His)
TMPK-00657
Species: Cynomolgus
Expression System: HEK293
Osteoprotegerin Protein, Human, Recombinant (hFc)
TMPY-05262
Species: Human
Expression System: Baculovirus-Insect Cells
ANXA2 Protein, Human, Recombinant
TMPJ-00799
Species: Human
Expression System: E. coli
OSCAR Protein, Mouse, Recombinant (hFc)
TMPK-01117
Species: Mouse
Expression System: HEK293
OSCAR Protein, Human, Recombinant (hFc)
TMPK-01092
Species: Human
Expression System: HEK293
Osteoprotegerin Protein, Mouse, Recombinant (hFc)
TMPY-04509
Species: Mouse
Expression System: HEK293
M-CSF/CSF1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00324
Species: Human
Expression System: HEK293
PRELP Protein, Human, Recombinant
TMPY-00572
Species: Human
Expression System: HEK293
PRELP Protein, Human, Recombinant (mFc)
TMPY-00571
Species: Human
Expression System: HEK293
M-CSF/CSF1 Protein, Cynomolgus, Recombinant (His)
TMPK-01325
Species: Cynomolgus
Expression System: HEK293
M-CSF/CSF1 Protein, Human, Recombinant (aa 33-190)
TMPK-00322
Species: Human
Expression System: HEK293
FNDC4 Protein, Human, Recombinant (mFc)
TMPY-00176
Species: Human
Expression System: HEK293
PSG7 Protein, Human, Recombinant (His)
TMPH-01987
Species: Human
Expression System: E. coli
M-CSF/CSF1 Protein, Rat, Recombinant
TMPJ-01218
Species: Rat
Expression System: Human Cells
Siglec-15 Protein, Mouse, Recombinant (His)
TMPJ-00225
Species: Mouse
Expression System: Human Cells
Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00217
Species: Human
Expression System: Human Cells
CSF1R Protein, Cynomolgus, Recombinant (hFc)
TMPJ-01418
Species: Cynomolgus
Expression System: Human Cells
RANK/TNFRSF11A Protein, Rat, Recombinant (hFc)
TMPY-03026
Species: Rat
Expression System: HEK293
RANK/TNFRSF11A Protein, Human, Recombinant (His)
TMPY-04157
Species: Human
Expression System: HEK293
Siglec-15 Protein, Cynomolgus, Recombinant (His)
TMPJ-00434
Species: Cynomolgus
Expression System: Human Cells
CSF1R Protein, Cynomolgus, Recombinant (His)
TMPJ-01419
Species: Cynomolgus
Expression System: Human Cells
ACP5 Protein, Human, Recombinant (His)
TMPY-00960
Species: Human
Expression System: HEK293
Osteomodulin Protein, Mouse, Recombinant (His)
TMPY-01472
Species: Mouse
Expression System: HEK293
ACP5 Protein, Mouse, Recombinant (His)
TMPY-01414
Species: Mouse
Expression System: HEK293
RANK/TNFRSF11A Protein, Human, Recombinant (mFc)
TMPY-05514
Species: Human
Expression System: HEK293
TargetMol