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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16159 | Muramyl dipeptide | MDP | NOD |
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation... | |||
T13324 | VUF11207 fumarate | CXCR , Arrestin | |
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1). | |||
T6739 | Zoledronic Acid | CGP-4244,CGP42446A,Zoledronate,CGP 42446,ZOL 446,Zometa | Apoptosis , Rho , Autophagy |
Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalc... | |||
T21299 | Zoledronic acid monohydrate | zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate | Apoptosis , Others , Autophagy |
Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity. | |||
T1925 | PLX647 | c-Fms , c-Kit | |
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM). | |||
T61531 | NFATc1-IN-1 | RANKL/RANK | |
NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuc... | |||
T0379 | Risedronic Acid | Risedronate | Others , Transferase |
Risedronic Acid (Risedronate), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption. | |||
T9823 | WAY-325398 | Others | |
WAY-325398 is a furan derivatives. WAY-325398 inhibits osteoclast formation, inhibition rate is 14.11% at 10 μM. | |||
T13159 | Tiludronate disodium | Tiludronic Acid disodium,Tiludronic acid disodium | ATPase |
Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disor... | |||
T9917 | Denosumab | RANKL/RANK | |
Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand | |||
T77567 | BCPA | Others | |
BCPA is a non-cytotoxic Pin1 modulator.BCPA modulates osteoclast activation and attenuates the reduction of Pin1 protein, thereby inhibiting RANKL-induced receptor activators of osteoclastogenesis.BCPA is used in the stu... | |||
T27371 | FR-167356 | FR167356,FR 167356 | ATPase |
FR-167356 is a specific inhibitor of a3 isoform vacuolar type H⁺-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces b... | |||
T2188 | Thonzonium Bromide | Proton pump , Antibacterial , Autophagy | |
Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteocl... | |||
T69656 | E197 | ||
E197 is a DOCK5 inhibitor. E197 can inhibit both mouse and human osteoclast activity. In particular, E197 prevented pathological bone loss in mice. Most interestingly, treatment with E197 did not affect osteoclast and os... | |||
T40328 | Betulinic acid derivative-1 | ||
Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM. | |||
T26514 | ABD56 | ABD-56,ABD 56 | |
ABD56 inhibits osteoclast formation and activity in vitro and in vivo. | |||
T29109 | VPC12249 | VPC-12249,VPC 12249 | |
VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity. | |||
T26512 | ABD-295 | ||
ABD-295 is an antiresorptive agent, osteoclast inhibitor, and biphenylsulfide derivative. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in ... | |||
T72008 | E09241 | ||
E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through c... | |||
T39037 | Tiludronate disodium hemihydrate | Tiludronic acid disodium hemihydrate | |
Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound that functions as an osteoregulator. It is primarily utilized in metabolic bone disorder research. This compound acts as a po... | |||
T83032 | Anti-osteoporosis agent-7 | ||
Compound 133, also known as Anti-osteoporosis agent-7, is a potential anti-osteoporosis agent that exhibits significant inhibition of osteoclast formation. | |||
T30089 | AP-22161 | AP22161,G7VE62573J,UNII-G7VE62573J,SCHEMBL7243003,AP 22161 | |
AP-22161 selectively binds the Src SH2 domain by targeting highly conserved phosphotyrosine binding to cysteine residues in the pocket. AP-22161 selectively inhibits Src SH2 binding and can be used to inhibit osteoclast ... | |||
T61764 | Zoledronic acid disodium tetrahydrate | ||
Zoledronic Acid (Zoledronate) disodium tetrahydrate is a potent third-generation bisphosphonate (BP), exhibiting strong anti-resorptive activity. It effectively inhibits osteoclast differentiation and apoptosis, while al... | |||
T71480 | Kahweol linoleate | ||
Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing... | |||
T68641 | Kahweol Acetate | ||
Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing ... | |||
T71478 | Kahweol stearate | ||
Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing... | |||
T68642 | Kahweol palmitate | ||
Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducin... | |||
T71479 | Kahweol oleate | ||
Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell ... | |||
T79472 | CSF1R-IN-17 | c-Fms | |
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM. It is capable of inhibiting osteoclast differentiation [1]. | |||
T82359 | G-{d-Arg}-GDSP | ||
G-{d-Arg}-GDSP, an RGD peptide analogue, binds to the adhesion receptor of integrins, inhibiting cellular attachment to fibronectin and osteoclast resorption [1]. | |||
T80108 | Hepcidin-1 (mouse) | ||
Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion. This compound also reduces FPN1 protein levels and boosts intra... | |||
T73885 | Methyl gerfelin | ||
Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA... | |||
T78208 | Leramistat | HMC-C-01-A,MBS2320 | Mitochondrial Metabolism |
Leramistat (HMC-C-01-A; MBS2320), a mitochondrial complex 1 inhibitor, plays a role in regulating cell and immune metabolism. It is effective in suppressing various conditions, including atopic dermatitis, autoimmune ski... | |||
T78037 | Hepcidin-1 (mouse) TFA | ||
Hepcidin-1 (mouse) TFA, an endogenous peptide hormone, regulates iron homeostasis by upregulating mRNA levels of TRAP, cathepsin K, and MMP-9, enhancing TRAP-5b protein secretion, and downregulating FPN1 protein levels, ... | |||
T81171 | SH491 | ||
SH491 (Compound 33) serves as an antiosteoporosis agent, effectively inhibiting RANKL-induced osteoclast differentiation in bone-marrow-derived monocytes (BMMs) with an IC50 of 11.8 nM. Additionally, SH491 suppresses the... | |||
T73056 | Tiludronate | Tiludronic acid | |
Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuola... | |||
T40463 | Relacatib | SB-462795 | |
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relac... | |||
T37409 | DPC-AJ1951 (trifluoroacetate salt) | DPC-AJ1951 (trifluoroacetate salt) | |
DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogen... | |||
T78816 | Anti-osteoporosis agent-4 | NF-κB | |
Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis. It effectively inhibits osteoclast formation, demonstrating an IC50 value of... | |||
T83848 | VnP-16 TFA | ||
VnP-16, a synthetic peptide fragment mirroring amino acids 270-281 of vitronectin (a multifunctional glycoprotein involved in cell attachment, migration, and spreading), promotes attachment and spreading of isolated huma... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3816 | Velutin | NF-κB , HIF/HIF Prolyl-Hydroxylase | |
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ... | |||
TN5888 | Toddaculin | Others | |
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in... | |||
TN1040 | Skullcapflavone II | COX , Antibacterial , TGF-beta/Smad | |
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of al... | |||
TN2347 | Methylsticin | Methysticin | Others |
Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neu... | |||
TN1149 | 6''-O-acetylsaikosaponin A | Others | |
6''-O-acetylsaikosaponin A is an acetyl saikosaponin isolated from the roots of Bupleurum chinense. Itshows some osteoclast-inhibiting activities | |||
T2731 | Usnic Acid | Usniacin | Antibacterial , Autophagy |
Usnic Acid (Usniacin) is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces necrosis in certain cells. | |||
T3384 | Wedelolactone | IKK Inhibitor II | Apoptosis , NF-κB , Lipoxygenase , Caspase |
Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. | |||
T3804 | Neomangiferin | Mangiferin 7-glucoside | Phosphatase |
Neomangiferin (Mangiferin 7-glucoside) has beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats. Neomangiferin and mangiferin inhibit tartrate-resistant acid phosphatase, a biochemical mar... | |||
T3488 | Tectorigenin | 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine | Apoptosis |
Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Re... | |||
T6S2099 | Geraniin | Antioxidant , TNF | |
1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ... | |||
T6677 | Sophocarpine | ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT | |
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. | |||
TN4785 | Picrasidine I | NF-κB , ROS , MAPK | |
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors. | |||
T83033 | Anti-osteoporosis agent-2 | ||
Anti-osteoporosis agent-2 (Compound 10) serves as an inhibitor of osteoclast differentiation induced by RANKL [1]. | |||
TMA1743 | Ergosterol peroxide | ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection | |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr... | |||
TN3802 | Dehydrodiconiferyl alcohol | Estrogen/progestogen Receptor | |
Dehydrodiconiferyl alcohol (DHCA) is a lignan isolated from calabash that inhibits osteoclast differentiation and oophorectomy induced bone loss by acting as an estrogen receptor agonist. | |||
T16846 | Sauristolactam | Saurolactam | Others |
Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated f... | |||
T27711 | Kahweol Eicosanate | J002075,J 002075,J-002075 | |
Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, ... | |||
T79932 | Eudebeiolide B | Plebeiolide D | NF-κB |
Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is applicable in the study of osteoclast-related diseases [1]. | |||
TN2143 | 3,7,4'-Trihydroxyflavone | Resokaempferol,5-Deoxykampferol | DNA |
3,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marro... | |||
TN1663 | Ganoderic acid DM | PARP , Androgen Receptor , CDK | |
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendr... | |||
TN4094 | Gallocatechin gallate | IL Receptor , NF-κB , ROS , MAPK , PPAR , Fatty Acid Synthase | |
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κB signaling; it also may have anti-diabeti... | |||
TN2533 | 1-Hydroxy-2,3,4,7-tetramethoxyxanthone | 5-HT Receptor | |
1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-... | |||
TN2534 | 1-Hydroxy-2,3,5-trimethoxyxanthone | IκB/IKK , Calcium Channel , NOS , 5-HT Receptor , COX | |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type vo... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00662 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) | Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i... | |||
TMPJ-00607 | RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thy... | |||
TMPJ-01252 | CLEC2D Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and im... | |||
TMPJ-00674 | RANK/TNFRSF11A Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acid... | |||
TMPJ-01466 | Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His) | Human | Human Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits ... | |||
TMPY-02575 | PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even... | |||
TMPJ-00327 | M-CSF/CSF1 Protein, Human, Recombinant (His) | Human | Human Cells |
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and th... | |||
TMPY-04142 | RANK/TNFRSF11A Protein, Human, Recombinant (hFc) | Human | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i... | |||
TMPY-04487 | Osteomodulin Protein, Human, Recombinant (His) | Human | HEK293 |
Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein that belongs to the small leucine-rich proteoglycan (SLRP) family and... | |||
TMPY-01703 | TREM-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b... | |||
TMPY-03674 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro... | |||
TMPY-02726 | RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro... | |||
TMPY-00432 | TREM-2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b... | |||
TMPY-01148 | TREM-2 Protein, Human, Recombinant (His) | Human | HEK293 |
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b... | |||
TMPY-03364 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant | Human | HEK293 |
Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane pro... | |||
TMPY-00875 | Leptin Protein, Human, Recombinant | Human | E. coli |
Leptin is one of the most important hormones secreted by adipocytes, as an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine, and pro-inflammatory immu... | |||
TMPH-02662 | Aldolase A Protein, Mouse, Recombinant (His) | Mouse | Baculovirus |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator... | |||
TMPH-02032 | GPRC5A Protein, Human, Recombinant (GST) | Human | E. coli |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator... | |||
TMPH-02365 | JC polyomavirus (JCV) Minor capsid protein VP2 (His) | JCPyV | E. coli |
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. | |||
TMPY-01194 | OSTM1 Protein, Human, Recombinant (His) | Human | HEK293 |
Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 associat... | |||
TMPJ-00349 | RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) | Human | Human Cells |
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANK... | |||
TMPY-04621 | OSTM1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 associat... | |||
TMPY-01724 | Osteoprotegerin Protein, Human, Recombinant (His) | Human | HEK293 |
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds t... | |||
TMPY-03323 | Osteoprotegerin Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 |
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds t... | |||
TMPK-00323 | M-CSF/CSF1 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of... | |||
TMPK-00657 | SPARC Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most abundant non-collagenous protein expressed in mineralized tissues.The capacity of SPARC to influence pathways involved in extracell... | |||
TMPY-05262 | Osteoprotegerin Protein, Human, Recombinant (hFc) | Human | Baculovirus-Insect Cells |
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds t... | |||
TMPJ-00799 | ANXA2 Protein, Human, Recombinant | Human | E. coli |
Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression r... | |||
TMPK-01117 | OSCAR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and n... | |||
TMPK-01092 | OSCAR Protein, Human, Recombinant (hFc) | Human | HEK293 |
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and n... | |||
TMPY-04509 | Osteoprotegerin Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds t... | |||
TMPK-00324 | M-CSF/CSF1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of... | |||
TMPY-00572 | PRELP Protein, Human, Recombinant | Human | HEK293 |
PRELP (proline/arginine-rich end leucine-rich repeat protein) is a member of the leucine-rich repeat (LRR) family of extracellular matrix proteins in connective tissue. In contrast with other members of the family, the N... | |||
TMPY-00571 | PRELP Protein, Human, Recombinant (mFc) | Human | HEK293 |
PRELP (proline/arginine-rich end leucine-rich repeat protein) is a member of the leucine-rich repeat (LRR) family of extracellular matrix proteins in connective tissue. In contrast with other members of the family, the N... | |||
TMPK-01325 | M-CSF/CSF1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of... | |||
TMPK-00322 | M-CSF/CSF1 Protein, Human, Recombinant (aa 33-190) | Human | HEK293 |
CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of... | |||
TMPY-00176 | FNDC4 Protein, Human, Recombinant (mFc) | Human | HEK293 |
FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of F... | |||
TMPH-01987 | PSG7 Protein, Human, Recombinant (His) | Human | E. coli |
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/u... | |||
TMPJ-01218 | M-CSF/CSF1 Protein, Rat, Recombinant | Rat | Human Cells |
Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and different... | |||
TMPJ-00225 | Siglec-15 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai... | |||
TMPJ-00217 | Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | Human Cells |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai... | |||
TMPJ-01418 | CSF1R Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | Human Cells |
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l... | |||
TMPY-03026 | RANK/TNFRSF11A Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i... | |||
TMPY-04157 | RANK/TNFRSF11A Protein, Human, Recombinant (His) | Human | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i... | |||
TMPJ-00434 | Siglec-15 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Human Cells |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contai... | |||
TMPJ-01419 | CSF1R Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Human Cells |
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l... | |||
TMPY-00960 | ACP5 Protein, Human, Recombinant (His) | Human | HEK293 |
Tartrate-resistant acid phosphatase (TRACP) or acid phosphatase 5, tartrate resistant (ACP5 or TRAP) is a glycosylated monomeric metalloenzyme expressed in mammals. TRACP is associated with osteoblast migration to bone r... | |||
TMPY-01472 | Osteomodulin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein that belongs to the small leucine-rich proteoglycan (SLRP) family and... | |||
TMPY-01414 | ACP5 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Tartrate-resistant acid phosphatase (TRACP) or acid phosphatase 5, tartrate resistant (ACP5 or TRAP) is a glycosylated monomeric metalloenzyme expressed in mammals. TRACP is associated with osteoblast migration to bone r... | |||
TMPY-05514 | RANK/TNFRSF11A Protein, Human, Recombinant (mFc) | Human | HEK293 |
TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i... | |||
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