nucleolar

Expression system: E. coli
Length: 1-764, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-670, Partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 2-482, Partial
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 251-455, Partial
Activity: Not Tested

Expression system: E. coli
Length: 251-455, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-292, Full Length
Activity: Not Tested

Midnolin Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is Q504T8.

Expression system: E. coli
Length: 1-208, Full Length of Isoform 2
Activity: Not Tested

Expression system: E. coli
Length: 1-208, Full Length of Isoform 2
Activity: Not Tested

Expression system: E. coli
Length: 1-323, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-153, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 193-747, Partial
Activity: Not Tested

Nucleophosmin Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P06748-1.

Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2 TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2 TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell cycle, acting as an important regulator of mitosis. TRF1 can be bound and modulated by two nucleolar GTP-binding proteins, nucleostemin (NS) and guanine nucleotide binding protein-like 3-like (GNL3L), which exhibit apparently opposite effects on the protein degradation of TRF1. TRF1 TERF1 may has associated with cancer. TRF1 may play a significant role in cell differentiation in non-small cell lung cancer (NSCLC). The expression level of TRF1 protein is significantly reduced in kidney cancer and the level is negatively correlated with malignant degree of the cancer. TRF1 expression in malignant gliomas cells, may play a role in the malignant progression of astroglial brain tumors.

MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. MKI67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells. MKI67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of MKI67-positive tumor cells is often correlated with the clinical course of cancer. It is also associated with ribosomal RNA transcription. Inactivation of antigen MKI67 leads to inhibition of ribosomal RNA synthesis. The MKI67 protein is a nuclear and nucleolar protein, which is tightly associated with somatic cell proliferation. Antibodies raised against the human MKI67 protein paved the way for the immunohistological assessment of cell proliferation, particularly useful in numerous studies on the prognostic value of cell growth in clinical samples of human neoplasms. MKI67 protein expression is an absolute requirement for progression through the cell-division cycle. Recently, MKI67 is proved to be an independent prognostic factor for disease-free survival (HR 1.5-1.72) in multivariate analyses studies using samples from randomized clinical trials with secondary central analysis of the biomarker. MKI67 was not found to be predictive for long-term follow-up after chemotherapy. Nevertheless, high KI-67 was found to be associated with immediate pathological complete response in the neoadjuvant setting, with an LOE of II-B. MKI67 could be considered as a prognostic biomarker for therapeutic decision.

Nucleophosmin Protein, Human, Recombinant (aa 2-294, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 34 kDa and the accession number is P06748-1.